This manuscript offers a critical understanding of 'development' in general and urban development planning in particular in India. Colonial urban planning kept influencing and shaping the development and future of cities. Independent India made a new beginning through strong belief in socialistic urban development and policy planning but it neglected the complex urban realities. Comprehensive-rational planning approach could not work well for socio-culturaly diverse urban places. Development seems have been exclusionary in practices due to which urban majority live in poor localities with inadequate social infrastructure and lack of basic services. Major cities have been facing severe crisis in terms of civic amenities, infrastructure, public transport, and other facilities. Though neoliberalization reinforces inequalities and uneven development in Indian cities but it can play an important role in revitalizing urban planning and materializing governance practices for inclusive development and urban sustainability.

Tuberculosis (TB) is the major cause of death worldwide. The enormity of the problem has been further worsened by the emergence of multi-drug resistant (MDR) strains and the dual infection with HIV. A newly identified TB threat which leaves patients virtually untreatable using currently available anti-TB drugs is XDR-TB. Fluoroquinoloes are increasingly being used in the treatment of mycobacterial infections especially, tuberculosis and leprosy. Ciprofloxacin is an antibiotic that is used to treat bacterial infections. Ciprofloxacin stops the multiplication of bacteria by inhibiting the reproduction and repair of their genetic material (DNA). Ciprofloxacin is used to treat infections of the skin, lungs, airways, bones, and joints caused by susceptible bacteria. Although the primary mechanism of their action is by inhibiting gyrase, other possible mechanisms can not be ruled out. The mechanism of quinolone resistance involves primarily mutations in the A and B subunits of the DNA gyrase. Another mechanism of resistance to quinolones is the efflux of the drug out of the cell. It is possible that fluoroquinolones may have some other mechanisms of action also.