|
Showing 1 - 3 of
3 matches in All Departments
The exploding field of epigenetics is challenging the dogma of
traditional Mendelian inheritance. Epigenetics plays an important
role in shaping who we are and contributes to our prospects of
health and disease. While early epigenetic research focused on
plant and animal models and in vitro experiments, population-based
epidemiologic studies increasingly incorporate epigenetic
components. The relevance of epigenetic marks, such as DNA
methylation, genomic imprinting, and histone modification for
disease causation has yet to be fully explored.This book covers the
basic concepts of epigenetic epidemiology, discusses challenges in
study design, analysis, and interpretation, epigenetic laboratory
techniques, the influence of age and environmental factors on
shaping the epigenome, the role of epigenetics in the developmental
origins hypothesis, and provides the state of the art on the
epigenetic epidemiology of various health conditions including
childhood syndromes, cancer, infectious diseases, inflammation and
rheumatoid arthritis, asthma, autism and other neurodevelopmental
disorders, psychiatric disorders, diabetes, obesity and metabolic
disorders, and atherosclerosis. With contributions from: Peter
Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many
other experts in epigenetics!
Now in its second edition, this book provides a state of the art
overview on basic concepts of epigenetic epidemiology and a
comprehensive review of the rapidly evolving field of human
epigenetics. Epigenetics plays an important role in shaping who we
are and contributes to our prospects of health and disease. Unlike
our genetic inheritance, our epigenome is malleable throughout the
lifecourse and is shaped by our environmental experiences.
Population-based epidemiologic studies increasingly incorporate
epigenetic components. These so called epigenome-wide association
studies (EWAS) contribute substantially to our understanding of the
relevance of epigenetic marks, such as DNA methylation, histone
modification, and non-coding RNAs for disease causation. Written by
leading experts in the field, the book opens with a comprehensive
introduction of the principles of epigenetic epidemiology and
discusses challenges in study design, analysis, and interpretation.
It summarizes the latest advances in epigenetic laboratory
techniques, the influence of age and environmental factors on
shaping the epigenome, the epigenetic clock, and the role of
epigenetics in the developmental origins hypothesis. The final part
focuses on epigenetic epidemiology of various health conditions
such as imprinting disorders, cancer, infectious diseases,
inflammation and rheumatoid arthritis, asthma, metabolic disorder
and vascular disease, as well as neurodevelopmental and psychiatric
disorders. Given its scope, Epigenetic Epidemiology is an
indispensable resource for researchers working in the field of
human epigenetics.
Now in its second edition, this book provides a state of the art
overview on basic concepts of epigenetic epidemiology and a
comprehensive review of the rapidly evolving field of human
epigenetics. Epigenetics plays an important role in shaping who we
are and contributes to our prospects of health and disease. Unlike
our genetic inheritance, our epigenome is malleable throughout the
lifecourse and is shaped by our environmental experiences.
Population-based epidemiologic studies increasingly incorporate
epigenetic components. These so called epigenome-wide association
studies (EWAS) contribute substantially to our understanding of the
relevance of epigenetic marks, such as DNA methylation, histone
modification, and non-coding RNAs for disease causation. Written by
leading experts in the field, the book opens with a comprehensive
introduction of the principles of epigenetic epidemiology and
discusses challenges in study design, analysis, and interpretation.
It summarizes the latest advances in epigenetic laboratory
techniques, the influence of age and environmental factors on
shaping the epigenome, the epigenetic clock, and the role of
epigenetics in the developmental origins hypothesis. The final part
focuses on epigenetic epidemiology of various health conditions
such as imprinting disorders, cancer, infectious diseases,
inflammation and rheumatoid arthritis, asthma, metabolic disorder
and vascular disease, as well as neurodevelopmental and psychiatric
disorders. Given its scope, Epigenetic Epidemiology is an
indispensable resource for researchers working in the field of
human epigenetics.
|
|