Although phosphorylation of proteins on tyrosine is relatively rare compared to phosphorylation on serine or threonine residues, the past two decades of research into PTP function have led to a great appreciation of the critical role PTPs have in regulating basic cellular processes. Among these important roles is the regulation of cellular signaling pathways related to metabolism. This volume contains chapters which highlight many aspects of PTP function in the context of metabolism. Given the growing obesity and diabetes epidemics in the United States and throughout the world, the desire to identify possible therapeutic targets for treatment of these diseases is a high priority. In many ways, PTPs may be attractive drug targets since they are amenable to targeting with small molecules; however many challenges abound in making PTP inhibitors.

Although phosphorylation of proteins on tyrosine is relatively rare compared to phosphorylation on serine or threonine residues, the past two decades of research into PTP function have led to a great appreciation of the critical role PTPs have in regulating basic cellular processes. Among these important roles is the regulation of cellular signaling pathways related to metabolism. This volume contains chapters which highlight many aspects of PTP function in the context of metabolism. Given the growing obesity and diabetes epidemics in the United States and throughout the world, the desire to identify possible therapeutic targets for treatment of these diseases is a high priority. In many ways, PTPs may be attractive drug targets since they are amenable to targeting with small molecules; however many challenges abound in making PTP inhibitors.

The ultimate photographic field guide to North American insects This amazing field guide enables you to identify all 783 families of insects currently recognized in the United States and Canada. Richly illustrated with more than 3,700 stunning photos along with keys to families for many of the orders, Insects of North America features a comprehensive introduction that discusses classification and nomenclature, insect diversity, global threats, the latest collecting and curatorial techniques, and the many ways these remarkable organisms impact society. Combined with in-depth taxonomic coverage, this is the essential resource for both professionals and amateurs interested in the most diverse group of animals on the planet. Covers all 783 insect families known to occur in the United States and Canada Features more than 3,700 color photos, with nearly every photo identified to species level Includes an illustrated glossary for easy reference in the field The first field companion of its kind since the publication of the Peterson guide in 1970 Ideal for entomology courses of all levels An invaluable resource for anyone interested in insects

"Last Words" is a devotional guide for the seven weeks leading up to Easter. Each section is a week-long reflection on one of Christ's last seven utterances as he was dying on the cross. In these seven "last words" we encounter a Savior who is simultaneously strong and weak, confident and frail, hopeful and hopeless, God and man. Each section is comprised of scripture, poetry, prose, visual art, devotional prompts, and questions to inspire you as you reflect on the sacrifice of Jesus. This book highlights original writing and art created by members of the Seventh-day Adventist congregation in San Luis Obispo, CA, combined with other devotional material in the Christian tradition.