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Protein Tyrosine Phosphatase Control of Metabolism (Paperback, Softcover reprint of the original 1st ed. 2013)
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Protein Tyrosine Phosphatase Control of Metabolism (Paperback, Softcover reprint of the original 1st ed. 2013)
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Although phosphorylation of proteins on tyrosine is relatively rare
compared to phosphorylation on serine or threonine residues, the
past two decades of research into PTP function have led to a great
appreciation of the critical role PTPs have in regulating basic
cellular processes. Among these important roles is the regulation
of cellular signaling pathways related to metabolism. This volume
contains chapters which highlight many aspects of PTP function in
the context of metabolism. Given the growing obesity and diabetes
epidemics in the United States and throughout the world, the desire
to identify possible therapeutic targets for treatment of these
diseases is a high priority. In many ways, PTPs may be attractive
drug targets since they are amenable to targeting with small
molecules; however many challenges abound in making PTP inhibitors.
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