This book presents the wealth of scientific evidence that our personality emerges from evolved primary emotions shared by all mammals. Yes, your dog feels love-and many other things too. These subcortically generated emotions bias our actions, alter our perceptions, guide our learning, provide the basis for our thoughts and memories, and become regulated over the course of our lives. Understanding personality development from the perspective of mammals is a groundbreaking approach and one that sheds new light on the ways in which we as humans respond to life events, both good and bad. Jaak Panksepp, famous for discovering laughter in rats and for creating the field of affective neuroscience, died in April 2017. This book forms part of his lasting legacy and impact on a wide range of scientific and humanistic disciplines. It will be essential reading for anyone trying to understand how we act in the world and the world's impact on us.

Recent years have witnessed a resurgence of interest in the possible role of brain acetylcholine in neuropsychiatric disease. Research in this area has involved the renewed investigation of the cholinomimetics physostigmine and arecoline, and has been facilitated by the development of new potential cholinomimetics such as dimethylaminoethanol (Deanol) and choline chloride. Current investigators also have taken advantage of new approaches to neurochemical studies. Increasingly sensitive assay techniques such as gas chromatography/mass spectrometry have allowed investigators to measure low concentra tions of choline and acetylcholine in brain tissues. Improved neuroanatomical procedures such as immunohistochemical staining and the use of microelectrodes and micropipets have enabled skilled investigators to begin to map central acetylcholine pathways and to dissect the component parts of the complex interactions between brain acetylcholine and other neurotransmitters. The convergence of data from both clinical and basic studies now suggest that brain acetylcholine may be involved in affective illness, several movement disorders, and some cognitive disturbances. The purpose of this book is to summarize recent clinical and pre-clinical investigations on the possible role of brain acetylcholine in several neurological and psychiatric disorders. The volume is divided into six major sections: (1) Brain Acetylcholine and Psychiatric Disorders; (2) Brain Acetylcholine and Movement Disorders; (3) Brain Acetylcholine and Cognitive Function; (4) The Electrophysiology of Cholinergic Agents; (5) Interactions of Brain Acetylcholine and Other Neurotransmitters; (6) Biochemical and Pharmacological Aspects of CholinergiC Treatment Strategies."