Comprehensive Precision Medicine holistically integrates essential and interconnecting disciplines that contribute to the make-up of Precision Medicine as we know it today. Encompassing almost 90 contributions from eminent scholars and professionals, the book's contents are organized across 3 volumes and 7 major subject areas, each representing a key pillar driving the evolution and progression of healthcare delivery. Precision medicine approaches will transform the training and practice of all aspects of professional healthcare delivery, including medicine, nursing, pharmacy, psychology, rehabilitation, and social work. This will be a fundamental reference resource for students, post-graduate trainees, researchers, scientists and clinicians interested in precision medicine. Additionally, this resource will be of interest to regulators, policy makers, and public health practitioners across the globe.

Nonhuman primates represent a small fraction of animals used in biomedical research, but they remain important research models due to their similarities to humans with respect to genetic makeup, anatomy, physiology, and behavior. Limitations in the availability of nonhuman primates have been exacerbated by the COVID-19 pandemic and recent restrictions on their exportation and transportation, impacting National Institutes of Health (NIH)-funded research necessary for both public health and national security. Additionally, there is continued interest in understanding whether and how nonanimal models can be used to answer scientific questions for which nonhuman primates are currently used. At the direction of the U.S. Congress, NIH asked the National Academies of Sciences, Engineering, and Medicine to convene an expert committee to conduct a landscape analysis of current and future use of nonhuman primates in NIH-supported biomedical research, as well as opportunities for new approach methodologies to complement or reduce reliance on nonhuman primate models. This report provides the committee findings and conclusions. Table of Contents Front Matter Summary 1 Introduction 2 Contribution of Nonhuman Primate Models to Advances in Human Health 3 Current Landscape of Use and Availability of Nonhuman Primates for NIH-Supported Biomedical Research 4 The Landscape of New Approach Methodologies 5 Future Needs and Opportunities for Nonhuman Primate Models in Biomedical Research Appendix A: Study Approach and Methods Appendix B: Data on Nonhuman Primate Use in NIH-Supported Biomedical Research Appendix C: Biographical Sketches of Committee Members and Staff Appendix D: Disclosure of Unavoidable Conflicts of Interest