Scientists have reached a critical point in the development of new therapies for prostate cancer. The information gleaned from the Human Genome Project, alongside the emergence of new technologies for the use of genetic data has expanded the physician's understanding of disease progression and widened his armamentarium for prostate cancer prevention and control. This expertly-written reference thoroughly analyzes the scientific principles and methodologies behind the most recent translational therapies and provides the necessary context, data, and studies for practitioners to select appropriate candidates for treatment and effectively apply new therapies in clinical practice.

Scientists have reached a critical point in the development of new therapies for prostate cancer. The information gleaned from the Human Genome Project, alongside the emergence of new technologies for the use of genetic data has expanded the physician's understanding of disease progression and widened his armamentarium for prostate cancer prevention and control. This expertly-written reference thoroughly analyzes the scientific principles and methodologies behind the most recent translational therapies and provides the necessary context, data, and studies for practitioners to select appropriate candidates for treatment and effectively apply new therapies in clinical practice.

Wise, practical, optimistic life advice from author and leading technology thinker Kevin Kelly On his 68th birthday, Kevin Kelly began to write down for his young adult children some things he had learned about life that he wished he had known earlier. To his surprise, Kelly had more to say than he thought, and kept adding to the advice over the years, compiling a life's wisdom into these pages. Kelly's timeless advice covers an astonishing range, from right living to setting ambitious goals, optimizing generosity, and cultivating compassion. He has wisdom for career, relationships, parenting, and finances, and gives guidance for practical matters ranging from travel to troubleshooting. Excellent Advice for Living is aimed primarily at young people, but speaks to all ages. This is the ideal companion for anyone seeking to navigate life with grace and creativity.

The goal of teaching online is fundamentally the same as teaching face-to-face: facilitating the learning of all students to the greatest extent possible. This book differs from other books on online teaching in that, in the process of offering guidance on course design and planning, developing outcomes and appropriate engaging activities, managing the workload and assessment, the authors pay explicit attention throughout to the distinct and diverse needs of students and offer effective strategies to accommodate them in a comprehensive and inclusive way by using the principles of Universal Design for Learning. By following those principles from the outset when planning a course, all students will benefit, and most particularly those whom the research shows have the greatest achievement gaps when taking online courses -- males, first generation and low income students, those from underrepresented minority groups, the academically underprepared, students with disabilities, and those with limited online access or lacking readiness for online learning. Beyond good planning and design, Kelly and Zakrajsek offer ideas for creating inclusive course environments and activities, such using culturally appropriate content and making it accessible in multiple formats. They also share methods to foster faculty-learner interaction and increase personal connections with students, and among students, through group activities or learning communities, which are so critical to motivation and success. Faculty new to online teaching as well as more experienced readers will find a wealth of practical guidance on developing and honing both fully online and blended courses and, as importantly, a wealth of proven ideas to help the new generation of students with diverse needs to succeed.

The goal of teaching online is fundamentally the same as teaching face-to-face: facilitating the learning of all students to the greatest extent possible. This book differs from other books on online teaching in that, in the process of offering guidance on course design and planning, developing outcomes and appropriate engaging activities, managing the workload and assessment, the authors pay explicit attention throughout to the distinct and diverse needs of students and offer effective strategies to accommodate them in a comprehensive and inclusive way by using the principles of Universal Design for Learning. By following those principles from the outset when planning a course, all students will benefit, and most particularly those whom the research shows have the greatest achievement gaps when taking online courses -- males, first generation and low income students, those from underrepresented minority groups, the academically underprepared, students with disabilities, and those with limited online access or lacking readiness for online learning. Beyond good planning and design, Kelly and Zakrajsek offer ideas for creating inclusive course environments and activities, such using culturally appropriate content and making it accessible in multiple formats. They also share methods to foster faculty-learner interaction and increase personal connections with students, and among students, through group activities or learning communities, which are so critical to motivation and success. Faculty new to online teaching as well as more experienced readers will find a wealth of practical guidance on developing and honing both fully online and blended courses and, as importantly, a wealth of proven ideas to help the new generation of students with diverse needs to succeed.

In a book about the marriage of the born and the made--the biologicalization of everything from computers to government--the executive editor of Wired chronicles the dawn of a new era in which the machines and systems that dri ve our economy are so complex and autonomous as to be indistinguishable from living things.

A growing number of people completing or holding graduate degrees now seek non-faculty positions-also called alternative academic, or "alt-ac" positions--at different stages in their careers. While an increasing number of people with doctoral degrees are hunting for a diminishing pool of tenure-track faculty jobs, most degree-granting institutions do not adequately prepare their graduate students to enter the new reality of the alt-ac job market. Yet the administrative ranks in higher education institutions are growing, as colleges and universities are creating a diverse range of positions that support teaching and learning efforts. Focusing on the range of potential alternative career choices, this highly practical book offers tools and prompts for readers who are: Considering whether to choose an alt-ac career path Seeking specific alt-ac positions Advising graduate students or mentoring recent professional graduates Encountering alt-ac career challenges The authors offer case stories-their own and those of colleagues across North America in alt-ac roles-with concrete examples designed to help readers pursue, obtain, and excel in a wide variety of alt-ac positions. The book can equally be used as a resource for graduate courses on professional development and job-market preparation.

A growing number of people completing or holding graduate degrees now seek non-faculty positions-also called alternative academic, or "alt-ac" positions--at different stages in their careers. While an increasing number of people with doctoral degrees are hunting for a diminishing pool of tenure-track faculty jobs, most degree-granting institutions do not adequately prepare their graduate students to enter the new reality of the alt-ac job market. Yet the administrative ranks in higher education institutions are growing, as colleges and universities are creating a diverse range of positions that support teaching and learning efforts. Focusing on the range of potential alternative career choices, this highly practical book offers tools and prompts for readers who are: Considering whether to choose an alt-ac career path Seeking specific alt-ac positions Advising graduate students or mentoring recent professional graduates Encountering alt-ac career challenges The authors offer case stories-their own and those of colleagues across North America in alt-ac roles-with concrete examples designed to help readers pursue, obtain, and excel in a wide variety of alt-ac positions. The book can equally be used as a resource for graduate courses on professional development and job-market preparation.

This is a 3-volume set of oversize books that span the continent of Asia. Ancient and beautiful traditions in Asia that are rapidly disappearing are recorded here in 9,000 images on 1,000 pages. The author has visited 35 countries in Asia and has travelled to the end of the road in its most remote places to capture the costumes, architecture, festivals, and lifestyles that are vanishing. The diverse cultures range from Turkey in the west to Japan in the east, from Siberia in the north to Indonesia in the south, and everything in between. Volume 1 covers West Asia, Volume 2 Central Asia, and Volume 3 East Asia. Every one of its 1,000 pages is uniquely designed, and every one of its 9,000 images is captioned. This is an ambitious and extreme passion project that the author/photographer has worked on for 49 years.  Many of the scenes depicted in the book are now gone from the world, and others are becoming rarer by the day. There is no other book like it.

"More thriller than primer, this is the best technology book I have ever read." -Nicholas Negroponte, author of "Being Digital"

In this provocative book, one of today's most respected thinkers turns the conversation about technology on its head by viewing technology as a natural system, an extension of biological evolution. By mapping the behavior of life, we paradoxically get a glimpse at where technology is headed-or "what it wants." Kevin Kelly offers a dozen trajectories in the coming decades for this near-living system. And as we align ourselves with technology's agenda, we can capture its colossal potential. This visionary and optimistic book explores how technology gives our lives greater meaning and is a must-read for anyone curious about the future.

A New York Times Bestseller From one of our leading technology thinkers and writers, a guide through the twelve technological imperatives that will shape the next thirty years and transform our lives Much of what will happen in the next thirty years is inevitable, driven by technological trends that are already in motion. In this fascinating, provocative new book, Kevin Kelly provides an optimistic road map for the future, showing how the coming changes in our lives--from virtual reality in the home to an on-demand economy to artificial intelligence embedded in everything we manufacture--can be understood as the result of a few long-term, accelerating forces. Kelly both describes these deep trends--interacting, cognifying, flowing, screening, accessing, sharing, filtering, remixing, tracking, and questioning--and demonstrates how they overlap and are codependent on one another. These larger forces will completely revolutionize the way we buy, work, learn, and communicate with each other. By understanding and embracing them, says Kelly, it will be easier for us to remain on top of the coming wave of changes and to arrange our day-to-day relationships with technology in ways that bring forth maximum benefits. Kelly's bright, hopeful book will be indispensable to anyone who seeks guidance on where their business, industry, or life is heading--what to invent, where to work, in what to invest, how to better reach customers, and what to begin to put into place--as this new world emerges. From the Hardcover edition.

The second edition of Oncology Clinical Trials has been thoroughly revised and updated and now contains the latest designs and methods of conducting and analyzing cancer clinical trials in the era of precision medicine with biologic agents-including trials investigating the safety and efficacy of targeted therapies, immunotherapies, and combination therapies as well as novel radiation therapy modalities. Now divided into five sections this revamped book provides the necessary background and expert guidance from the principles governing oncology clinical trials to the innovative statistical design methods permeating the field; from conducting trials in a safe and effective manner, analyzing and interpreting the data, to a forward-looking assessment and discussion of regulatory issues impacting domestic, international, and global clinical trials. Considered by many as the gold standard reference on oncology clinical trials in the field, the second edition continues to provide examples of real-life flaws and real-world examples for how to successfully design, conduct and analyze quality clinical trials and interpret them. With chapters written by oncologists, researchers, biostatisticians, clinical research administrators, and industry and FDA representatives, this volume provides a comprehensive guide in the design, conduct, monitoring, analysis, and reporting of clinical trials in oncology. New to this Edition: Outlines how to design clinical trials with and without biomarker testing-including genomics-based "basket" trials, and adaptive trials for all phases during treatment and quality-of-life trials Includes new chapters on immunotherapy trials, radiation therapy trials, multi-arm trials, meta-analysis and adaptive design, use of genomics, dose modifications and use of ancillary treatments in investigational studies, establishing surrogate endpoints, practical issues with correlative studies, cost-effectiveness analysis, and more Comprehensively covers all regulatory aspects in the pursuit of global oncology trials Digital Access to the eBook included

The Third Testament; fab' u*lous*ly un*con*ven*tion*al Bible, is a humorously unorthodox yet motivating book inspired by the modern woman and all the other chick-lit out there, including fairy tales. It is an unconventional approach to addressing the age old female subject matter of confidence. Through humor, it nudges women of all ages in the direction towards empowerment and the much needed education of self esteem and mental independence while never compromising morals or femininity. Encouraging woman to accept that they can still be giggling little girls as well as paragons of strength without being forced into choosing or sacrificing either side of themselves.

The Irish government, UK government and European Commission have recently passed a ban on the sale of all incandescent/GLS lamps above 100W, which commenced in September 2009 with smaller Wattages to be phased out by 2012. This paper sets out to investigate if CFLs are an adequate, suitable and appropriate replacement for GLS lamps in domestic environments. The main areas examined are power factor and total harmonic distortion, but other CFL characteristics are also investigated by means of literature review, to provide a complete overview of CFL performance. The measured power factor of all CFLs averaged 0.57 and ranged between 0.52 and 0.62. The effects of harmonic distortion on the current waveform of a CFL circuit was significant and reached levels up to 80% of the fundamental frequency. However, this large harmonic distortion is returned on the waveform of a smaller current than would be drawn by a GLS lamp and hence, effects on the national grid and risks of an overloaded three phase neutral conductor are less than sometimes claimed by researchers.

A project began as a post occupancy evaluation of lighting controls installed in a range of buildings. Actual controlled lighting consumption was to be compared against past billing or simulated energy consumption. However, when the research began it was found that the controls had been removed from two out of the three buildings. This raised a much bigger research question as to why were the controls disconnected and what were the factors governing success or failure of these systems? A whole new methodology from that first envisaged had to be established. To find out what people know, or think, it is necessary to ask them. A framework was created to determine if there was correlation between past findings and the reasons for failure in the case studies. The research that followed posed many difficult challenges including the use of qualitative data in an engineering environment. Some of the findings included: Comparatively high maintenance costs Misinterpretations of commissioning processes Incomplete analysis prior to installation The requirement for post occupancy evaluation in current engineering practices"

This is a Doctoral thesis undertaken by an experienced academic in the Engineering Faculty of a Higher Education Institute in Ireland. It examines the demand for universities to change in response to a fast changing external environment. The research explores how stakeholders are responding to the demands for change and how a bureaucratic organisation is attempting to become more responsive and innovative.

A description of the anthology DEATH AND ANTI-DEATH, VOLUME 5: THIRTY YEARS AFTER LOREN EISELEY (1907-1977) follows: Volume 5, as indicated by the anthology's subtitle, is in honor of Loren Eiseley (1907-1977). The chapters do not necessarily mention him. The chapters (by professional philosophers and other professional scholars) are directed to issues related to death, life extension, and anti-death. Most of the contributions consist of scholarship unique to this volume. As was the case with all previous volumes in the Death And Anti-Death Series By Ria University Press, the anthology includes an Index as well as an Abstracts section that serves as an extended table of contents. (With Volume 5, you will also find a new section entitled BRIEF COMMUNICATIONS.) The 17 chapter titles are as follows: 1. Asking The Unaskable Question - Do People Have The Right NOT To Die? (by Marcus Barber) ----- 2. Deadly Economics: Reflections On The Neoclassical Paradigm (by Giorgio Baruchello) ----- 3. A Frozen Future? Cryonics As A Gamble (by Gregory Benford) ----- 4. Three Big Problems (by Nick Bostrom and Rebecca Roache) ----- 5. A World Of Exception: Exploring The Thought Of Loren Eiseley (by Marcus Bussey) ----- 6. Knowledge And Death: Return To The Garden (by Harry Hillman Chartrand) ----- 7. Is It Safe For A Biologist To Support Cryonics Publicly? (by Aubrey D.N.J. de Grey) ----- 8. Taking The Defeat Of Aging Seriously: The Time Is Now (by Aubrey D.N.J. de Grey) ----- 9. Choosing Death In Cases Of Anorexia Nervosa - Should We Ever Let People Die From Anorexia? (by Simona Giordano) ----- 10. Technologies Don't Die (by Kevin Kelly) ----- 11. Intimate Moments Among The Dead: Death And Time In The Work Of Loren Eiseley (by Lawrence Kimmel) ----- 12. No Turning Back: Past-Directed Time Travel Is Scientifically Unlikely, Though Virtual Alternatives May Still Offer Solace (by R. Michael Perry) ----- 13. Embodiments Of Paradise: Symbolism Of Death As Existential Mastery In Jihadism (by Arthur Saniotis) ----- 14. On Death And Dying: Summing Up At 70 (by Arthur B. Shostak) ----- 15. Once Upon A Time (by Stanley Shostak) ----- 16. Teleological Causes And The Possibilities Of Personhood (by Charles Tandy) ----- 17. Terrestrial Peoples, Extraterrestrial Persons (by Charles Tandy) ----- ----- The TITLE of the anthology is: Death And Anti-Death, Volume 5: Thirty Years After Loren Eiseley (1907-1977). It's EDITOR is: Charles Tandy, Ph.D. It's ISBN is: 978-1-934297-02-5. It's PUBLISHER is: Ria University Press. It's DISTRIBUTOR is: Ingram.

Forget supply and demand. Forget computers. The old rules are broken. Today, communication, not computation, drives change. We are rushing into a world where connectivity is everything, and where old business know-how means nothing. In this new economic order, success flows primarily from understanding networks, and networks have their own rules. In New Rules for the New Economy, Kevin Kelly presents ten fundamental principles of the connected economy that invert the traditional wisdom of the industrial world. Succinct and memorable, New Rules explains why these powerful laws are already hardwired into the new economy, and how they play out in all kinds of business--both low and high tech--all over the world. More than an overview of new economic principles, it prescribes clear and specific strategies for success in the network economy. For any worker, CEO, or middle manager, New Rules is the survival kit for the new economy.

Financed by fans, this huge graphic novel is the coming-of-age story of a teenage girl. Set in a unique and original world filled with both angels and robots, her story is a page-turning techno-epic that recounts the clash between self-conscious robots and a million different species of angels. While pure cinematic fantasy, the story anticipates the real issue of whether machines can have souls and will wow graphic novel fans in search of new heroes and new worlds. This spectacular, oversized, lusciously printed 420-page graphic novel combines the two worlds of high-technology and deep spirituality. The book was financed by the robust fans of a successful Kickstarter campaign.