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Ovarian Cancer Biomarkers - Mapping to Improve Outcomes (Hardcover, 1st ed. 2021): Khalid El Bairi Ovarian Cancer Biomarkers - Mapping to Improve Outcomes (Hardcover, 1st ed. 2021)
Khalid El Bairi
R4,575 Discovery Miles 45 750 Ships in 10 - 15 working days

This book comprehensively summarizes the biology, etiology, and pathology of ovarian cancer and explores the role of deep molecular and cellular profiling in the advancement of precision medicine. The initial chapter discusses our current understanding of the origin, development, progression and tumorigenesis of ovarian cancer. In turn, the book highlights the development of resistance, disease occurrence, and poor prognosis that are the hallmarks of ovarian cancer. The book then reviews the role of deep molecular and cellular profiling to overcome challenges that are associated with the treatment of ovarian cancer. It explores the use of genome-wide association analysis to identify genetic variants for the evaluation of ovarian carcinoma risk and prognostic prediction. Lastly, it highlights various diagnostic and prognostic ovarian cancer biomarkers for the development of molecular-targeted therapy.

Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing - A Big Chapter in the Tale (Hardcover, 1st ed. 2020):... Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing - A Big Chapter in the Tale (Hardcover, 1st ed. 2020)
Khalid El Bairi
R4,821 Discovery Miles 48 210 Ships in 10 - 15 working days

This book reviews the potential of next-generation sequencing (NGS) in research on and management of colorectal cancer (CRC), a leading cause of death worldwide and one of the most biologically and clinically heterogeneous cancers. It critically discusses findings from recent large-scale studies, clinical trials and meta-analyses and offers an introduction to the management of CRC in the era of precision medicine. In CRC, dozens of driver and passenger mutations are associated with the malignant transformation of epithelial cells. Consequently, the book discusses recent advances in our understanding of the genetics of CRC as a biomarker, the advent of NGS technologies in modern genomics, and the impact of NGS technology on the management of CRC. Furthermore, it highlights the potential of NGS in the context of liquid biopsy and single-cell sequencing in CRC, as well as its role in shedding light on the link between gut microbiota, immune-checkpoint blockade and CRC. The book concludes with a chapter on the limitations and cost-effectiveness of NGS in CRC. Given its scope, the book will appeal to all those interested in learning about the potential of NGS in advancing CRC research and patient care.

Ovarian Cancer Biomarkers - Mapping to Improve Outcomes (Paperback, 1st ed. 2021): Khalid El Bairi Ovarian Cancer Biomarkers - Mapping to Improve Outcomes (Paperback, 1st ed. 2021)
Khalid El Bairi
R3,248 Discovery Miles 32 480 Ships in 10 - 15 working days

This book comprehensively summarizes the biology, etiology, and pathology of ovarian cancer and explores the role of deep molecular and cellular profiling in the advancement of precision medicine. The initial chapter discusses our current understanding of the origin, development, progression and tumorigenesis of ovarian cancer. In turn, the book highlights the development of resistance, disease occurrence, and poor prognosis that are the hallmarks of ovarian cancer. The book then reviews the role of deep molecular and cellular profiling to overcome challenges that are associated with the treatment of ovarian cancer. It explores the use of genome-wide association analysis to identify genetic variants for the evaluation of ovarian carcinoma risk and prognostic prediction. Lastly, it highlights various diagnostic and prognostic ovarian cancer biomarkers for the development of molecular-targeted therapy.

Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing - A Big Chapter in the Tale (Paperback, 1st ed. 2020):... Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing - A Big Chapter in the Tale (Paperback, 1st ed. 2020)
Khalid El Bairi
R4,787 Discovery Miles 47 870 Ships in 10 - 15 working days

This book reviews the potential of next-generation sequencing (NGS) in research on and management of colorectal cancer (CRC), a leading cause of death worldwide and one of the most biologically and clinically heterogeneous cancers. It critically discusses findings from recent large-scale studies, clinical trials and meta-analyses and offers an introduction to the management of CRC in the era of precision medicine. In CRC, dozens of driver and passenger mutations are associated with the malignant transformation of epithelial cells. Consequently, the book discusses recent advances in our understanding of the genetics of CRC as a biomarker, the advent of NGS technologies in modern genomics, and the impact of NGS technology on the management of CRC. Furthermore, it highlights the potential of NGS in the context of liquid biopsy and single-cell sequencing in CRC, as well as its role in shedding light on the link between gut microbiota, immune-checkpoint blockade and CRC. The book concludes with a chapter on the limitations and cost-effectiveness of NGS in CRC. Given its scope, the book will appeal to all those interested in learning about the potential of NGS in advancing CRC research and patient care.

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