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Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing - A Big Chapter in the Tale (Hardcover, 1st ed. 2020)
Loot Price: R4,821
Discovery Miles 48 210
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Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing - A Big Chapter in the Tale (Hardcover, 1st ed. 2020)
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This book reviews the potential of next-generation sequencing (NGS)
in research on and management of colorectal cancer (CRC), a leading
cause of death worldwide and one of the most biologically and
clinically heterogeneous cancers. It critically discusses findings
from recent large-scale studies, clinical trials and meta-analyses
and offers an introduction to the management of CRC in the era of
precision medicine. In CRC, dozens of driver and passenger
mutations are associated with the malignant transformation of
epithelial cells. Consequently, the book discusses recent advances
in our understanding of the genetics of CRC as a biomarker, the
advent of NGS technologies in modern genomics, and the impact of
NGS technology on the management of CRC. Furthermore, it highlights
the potential of NGS in the context of liquid biopsy and
single-cell sequencing in CRC, as well as its role in shedding
light on the link between gut microbiota, immune-checkpoint
blockade and CRC. The book concludes with a chapter on the
limitations and cost-effectiveness of NGS in CRC. Given its scope,
the book will appeal to all those interested in learning about the
potential of NGS in advancing CRC research and patient care.
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