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Animal Models of T Cell-Mediated Skin Diseases (Paperback, 2005 ed.): T Zollner, Harald Renz, Khusru Asadullah Animal Models of T Cell-Mediated Skin Diseases (Paperback, 2005 ed.)
T Zollner, Harald Renz, Khusru Asadullah
R4,490 Discovery Miles 44 900 Ships in 10 - 15 working days

Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.

Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases (Paperback, 2006 ed.): R. Numerof, Charles A.... Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases (Paperback, 2006 ed.)
R. Numerof, Charles A. Dinarello, Khusru Asadullah
R3,929 Discovery Miles 39 290 Ships in 10 - 15 working days

Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. Anti-TNF therapeutics have proven to be effective in the treatment of psoriasis, and clinical investigations have now begun for other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development. This book summarizes the findings of the 56th International Workshop of the Ernst Schering Research Foundation that focused on "Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases".

Immunotherapy in 2020 - Visions and Trends for Targeting Inflammatory Disease (Paperback, 2007 ed.): Andreas Radbruch,... Immunotherapy in 2020 - Visions and Trends for Targeting Inflammatory Disease (Paperback, 2007 ed.)
Andreas Radbruch, Hans-Dieter Volk, Khusru Asadullah, Wolf-Dietrich Doecke
R1,503 Discovery Miles 15 030 Ships in 10 - 15 working days

This volume features contributions from participants of the ESRF symposium on Immunotherapy in 2020-Visions and Trends for Targeting Inflammatory Diseases held in Potsdam near Berlin, Germany, in October 2006. The symposium presentations covered the main mechanisms of immunoregulation.

Leucocyte Trafficking - The Role of Fucosyltransferases and Selectins (Paperback, Softcover reprint of the original 1st ed.... Leucocyte Trafficking - The Role of Fucosyltransferases and Selectins (Paperback, Softcover reprint of the original 1st ed. 2004)
A.H. Amann, Khusru Asadullah, A Schottelius
R4,460 Discovery Miles 44 600 Ships in 10 - 15 working days

An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.

Immunotherapy in 2020 - Visions and Trends for Targeting Inflammatory Disease (Hardcover, 2007 ed.): Andreas Radbruch,... Immunotherapy in 2020 - Visions and Trends for Targeting Inflammatory Disease (Hardcover, 2007 ed.)
Andreas Radbruch, Hans-Dieter Volk, Khusru Asadullah, Wolf-Dietrich Doecke
R1,536 Discovery Miles 15 360 Ships in 10 - 15 working days

This volume features contributions from participants of the ESRF symposium on "Immunotherapy in 2020a "Visions and Trends for Targeting Inflammatory Diseases" held in Potsdam near Berlin, Germany, in October 2006.

The symposium presentations covered the main mechanisms of immunoregulation such as peripheral and central tolerance, epigenetic programming, immunologic memory, and regulatory networks in inflammation as well as novel experimental and clinical approaches for targeting inflammation in autoimmunity and transplantation. An important related question is how recent findings in immunological research can lead to improved diagnostics, new drugs, and better therapies. The targeting of novel pathways and immunoregulatory mechanisms, the challenge of immunologic memory for lastingly successful anti-inflammatory therapy, new approaches for adoptive T cell and polyclonal antibody therapies, and the individualization of immunomodulatory therapies are thereby topics of this volume.

Leucocyte Trafficking - The Role of Fucosyltransferases and Selectins (Hardcover, 2004 ed.): A.H. Amann, Khusru Asadullah, A... Leucocyte Trafficking - The Role of Fucosyltransferases and Selectins (Hardcover, 2004 ed.)
A.H. Amann, Khusru Asadullah, A Schottelius
R4,645 Discovery Miles 46 450 Ships in 10 - 15 working days

An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.

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