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Functional selectivity refers to the ability of different ligands
acting at one receptor subtype to activate multiple signaling
pathways in unique combinations; that is, one drug can be an
agonist at pathway A and an antagonist or partial agonist at
pathway B, and another drug can have the reverse profile.
Functional selectivity has profound implications for drug
development, for chemical biology, and for the design of
experiments to characterize receptor function. In Functional
Selectivity of G Protein-Coupled Receptors expert neuroscientists
and pharmacologists review the work that demonstrated the existence
of functional selectivity, placed it within a theoretical
framework, and provided a mechanistic basis for the phenomenon.
This exciting, comprehensive, and future-oriented volume includes
chapters that focus on theoretical and mechanistic aspects of
functional selectivity and that cut across subfamilies of GPCRs.
Additional chapters focus on subfamilies of therapeutically
relevant receptors where there is considerable evidence of ligand
functional selectivity. Accessible and authoritative, Functional
Selectivity of G Protein-Coupled Receptors is a valuable
educational tool and reference source for students and scientists
interested in drug development, chemical biology, and GPCR
function.
As sites of action for drugs used to treat schizophrenia and
Parkinson s disease, dopamine receptors are among the most
validated drug targets for neuropsychiatric disorders. Dopamine
receptors are also drug targets or potential targets for other
disorders such as substance abuse, depression, Tourette s syndrome,
and attention deficit hyperactivity disorder. Updated from the
successful first edition, "The Dopamine Receptors" serves as a
reference work on dopamine receptors while also highlighting the
areas of research that are most active today. To achieve this goal,
authors have written chapters that set a broad area of research in
its historical context, rather than focusing on the research output
of their own laboratories. "
As sites of action for drugs used to treat schizophrenia and
Parkinson s disease, dopamine receptors are among the most
validated drug targets for neuropsychiatric disorders. Dopamine
receptors are also drug targets or potential targets for other
disorders such as substance abuse, depression, Tourette s syndrome,
and attention deficit hyperactivity disorder. Updated from the
successful first edition, "The Dopamine Receptors" serves as a
reference work on dopamine receptors while also highlighting the
areas of research that are most active today. To achieve this goal,
authors have written chapters that set a broad area of research in
its historical context, rather than focusing on the research output
of their own laboratories. "
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