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Functional Selectivity of G Protein-Coupled Receptor Ligands - New Opportunities for Drug Discovery (Paperback, Softcover reprint of the original 1st ed. 2009)
Loot Price: R3,300
Discovery Miles 33 000
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Functional Selectivity of G Protein-Coupled Receptor Ligands - New Opportunities for Drug Discovery (Paperback, Softcover reprint of the original 1st ed. 2009)
Series: The Receptors
Expected to ship within 10 - 15 working days
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Functional selectivity refers to the ability of different ligands
acting at one receptor subtype to activate multiple signaling
pathways in unique combinations; that is, one drug can be an
agonist at pathway A and an antagonist or partial agonist at
pathway B, and another drug can have the reverse profile.
Functional selectivity has profound implications for drug
development, for chemical biology, and for the design of
experiments to characterize receptor function. In Functional
Selectivity of G Protein-Coupled Receptors expert neuroscientists
and pharmacologists review the work that demonstrated the existence
of functional selectivity, placed it within a theoretical
framework, and provided a mechanistic basis for the phenomenon.
This exciting, comprehensive, and future-oriented volume includes
chapters that focus on theoretical and mechanistic aspects of
functional selectivity and that cut across subfamilies of GPCRs.
Additional chapters focus on subfamilies of therapeutically
relevant receptors where there is considerable evidence of ligand
functional selectivity. Accessible and authoritative, Functional
Selectivity of G Protein-Coupled Receptors is a valuable
educational tool and reference source for students and scientists
interested in drug development, chemical biology, and GPCR
function.
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