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Over the past decade, genome sequencing projects and the associated
efforts have facilitated the discovery of several novel disease
targets and the approval of several innovative drugs. To further
exploit this data for human health and disease, there is a need to
understand the genome data itself in detail, discover novel
targets, understand their role in physiological pathways and
associated diseases, with the aim to translate these discoveries to
clinical and preventive medicine. It is equally important to
understand the labors and limitations in integrating clinical
phenotypes with genomic, transcriptomic, proteomic and metabolomic
approaches. This book focuses on some key advances in the field.
Technical topics discussed in the book include: * Drug discovery *
Target identification and prioritization * Hypothesis driven
multi-target drug design * Genomics in vaccine development * Gene
regulatory networks * Vaccine design and development * Prediction
of drug side effects in silico
Understanding the molecular mechanisms of cancer is the key for
transforming cancer medicine. A substantial proportion of human
genes show alternative splicing and mis-regulation of Pre-mRNA
splicing is seen in several cancers. This book further investigates
these matters. The first few chapters provide an update on the role
of genomics in understanding alternative splicing, and targets in
cancer pathogenesis. Advances and prospects in applications of
nanotechnology for cancer prevention, detection and treatment are a
promising field of research. The subsequent chapters provide
insights on how nanotechnology-based therapeutics are moving
towards revolutionizing cancer and infectious disease treatment by
minimizing toxicity and facilitating targeted delivery of drugs.
Technical topics discussed in the book include: * Alternative
splicing and cancer * Cancer imaging * Nanomaterials in infectious
diseases * Nanomedicine in oxidative stress and cancer *
Nanoparticle based drug delivery systems
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Loot
Nadine Gordimer
Paperback
(2)
R398
R330
Discovery Miles 3 300
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