Over the past decade, genome sequencing projects and the associated
efforts have facilitated the discovery of several novel disease
targets and the approval of several innovative drugs. To further
exploit this data for human health and disease, there is a need to
understand the genome data itself in detail, discover novel
targets, understand their role in physiological pathways and
associated diseases, with the aim to translate these discoveries to
clinical and preventive medicine. It is equally important to
understand the labors and limitations in integrating clinical
phenotypes with genomic, transcriptomic, proteomic and metabolomic
approaches. This book focuses on some key advances in the field.
Technical topics discussed in the book include: * Drug discovery *
Target identification and prioritization * Hypothesis driven
multi-target drug design * Genomics in vaccine development * Gene
regulatory networks * Vaccine design and development * Prediction
of drug side effects in silico
General
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