This book constitutes the refereed proceedings of the 11th International Conference on Intelligent Tutoring Systems, ITS 2012, held in Chania, Crete, Greece, in June 2012. The 28 revised full papers, 50 short papers, and 56 posters presented were carefully viewed and selected from 177 submissions. The specific theme of the ITS 2012 conference is co-adaption between technologies and human learning. Besides that, the highly interdisciplinary ITS conferences bring together researchers in computer science, informatics, and artificial intelligence on the one side - and cognitive science, educational psychology, and linguistics on the other side. The papers are organized in topical sections on affect/emotions, affect/signals, games/motivation and design, games/empirical studies, content representation, feedback, non conventional approaches, conceptual content representation, assessment constraints, dialogue, dialogue/questions, learner modeling, learning detection, interaction strategies for games, and empirical studies thereof in general.