|
Showing 1 - 2 of
2 matches in All Departments
Primary liver cancer is a rather unusual malignancy in that the
incidence varies tremendously from one geographical area to
another. While relatively uncom mon in Western countries, it is the
most prevalent malignant neoplasm in Southeast Asia, South Africa,
and many other regions; in all, the countries in which primary
liver cancer is very prevalent account for more than two-thirds of
the world's population. In China alone, approximately 100 000
people die every year from primary liver cancer, mostly
hepatocellular carcinoma. The incidence is rising in some
countries, especially Japan, where it has doubled among males in
the past 15 years or so, a staggering and puzzling trend. Since the
demonstration of an etiological relationship between hepatitis B
virus infection and hepatocellular carcinoma, intensive research
has been con ducted in an effort to elucidate the role of the virus
in hepatocarcinogenesis. Though much progress has been made, a full
understanding of the molecular events leading to malignant
transformation of the hepatocyte will probably require many more
years of rigorous investigation. Chemical carcinogens and several
industrial pollutants may also be involved in the etiopathogenesis
of neoplastic liver disease."
Portal hypertension is the abnormal pathophysiologic state that
develops in liver cirrhosis and certain other disorders with
characteristic clinical and hemodynamic features. There has been
great progress in our under standing and management of portal
hypertension, particularly in the diagnostic and therapeutic
approaches. The so-called Banti's syndrome, a disorder whose
existence had long been questioned, is now a well-defined portal
hypertensive disease. The recently introduced Doppler ftowmetry is
currently yielding new information on portal hemodynamics.
Endoscopic sclerotherapy and beta-blockers have come to be widely
used in the man agement and prevention of variceal bleeding. In
spite of all these advances, a number of unsolved questions remain,
such as whether sclerotherapy, pharmacotherapy or surgery is
warranted for prevention of bleeding, which is more effective as an
elective treatment, the surgical or endoscopic approach, and
whether surgical portacaval shunt should be totally replaced by
selective shunt operations. These new developments and problems are
clearly and comprehensively described and discussed by the foremost
authorities in 44 chapters, which are divided into five sections:
1) Patho physiology, 2) Hemodynamic Investigations, 3) Imaging
Investigations, 4) Clinical and Pathological Features, and 5)
Esophageal and Gastrointestinal Bleeding. The primary goal of this
monograph, to provide a framework of patho physiology of portal
hypertension with authoritative descriptions of the clinical and
laboratory manifestations of various portal hypertensive dis
orders, has clearly been achieved by these excellent contributions.
|
You may like...
Tenet
John David Washington, Robert Pattinson
Blu-ray disc
(1)
R54
R45
Discovery Miles 450
Loot
Nadine Gordimer
Paperback
(2)
R398
R330
Discovery Miles 3 300
|