|
Showing 1 - 2 of
2 matches in All Departments
The First International Symposium on Mechanism and Treatment in
Essential Hypertension was held on October 23 and 24, 1985 in
Nagoya. The Second International Symposium, which was held on May
30,31, and June 1, 1988 in Nagoya, was a success thanks to the
endeavors of all the participants. These symposiums were made
possible by the generous support of the city of Nagoya, Aichi
Prefec ture, and various contributions. Understanding of the
mechanisms of gene (major gene, essential) hypertension is
impossible unless we comprehend the physiological properties of
arterial smooth muscle. Since Langendorff's discovery of the role
of calcium ions in muscle contraction in 1895, we have made immense
progress in our knowledge of the role of the calcium ion in the
excitation-contraction coupling of the arterial smooth mus cle.
Investigation of the molecular mechanisms controlling the cellu lar
basis of calcium ion action has been established with the discovery
of the calcium binding protein (Ebashi 1963). The participation of
the calcium induced calcium mechanism in the contraction of muscle
has been directly demonstrated by using chemically skinned smooth
muscle fibers (Endo et al. 1977). Methods for intracellular free
cal cium contents and calcium channel activity have been developed
and contribute to the study of the role of the calcium ion in
arterial smooth muscle contractility. Such recent progress promotes
study of the basic physiological, biochemical, and molecular
properties of the calcium channel, and, in the field of
hypertension research, the sodium and potassium channels."
This volume contains papers presented at the First International
Symposium on Mechanism and Treatment in Essential Hyperten sion,
which was held on October 23 and 24, 1985 in Nagoya, Japan. The
meeting was an official satellite symposium to the meeting of the
Fifth International Symposium on Rats with Spon taneous
Hypertension and Related Studies in Kyoto, October 20-22, 1985. The
Nagoya symposium was made possible by offi cial grants from the
city of Nagoya and Aichi Prefecture and the generous financial
support of many companies. The aim of the symposium was to provide
a forum for presen tation and discussion of recent advances in the
area of essential hypertension, particularly with regard to calcium
mechanisms in vasoconstriction and vasodilation in arterial vessels
and the func tion of arterial smooth muscle. The role of calcium
ions in the function of arterial smooth muscle has attracted a
great deal of attention in the last two decades. The mode of action
of calcium ions was revealed at the molecular level. The
hypertension model of the spontaneously hypertensive rat has been
widely utilized for research into the fundamental mechanisms of
genetic hyperten sion, stroke, and cardiovascular disease as well
as into therapeutic measures. New tools of calcium agonists and
antagonists have become available to research into the mechanism,
prevention, and treatment of essential hypertension at the
molecular, subcellular, and cellular levels of arterial smooth
muscle, at the organ level of arterial vessels, as well as at the
total systemic level."
|
|