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Recent advances in molecular biology have shown GTPases and
phosphoproteins to be the paramount molecular switches utilized
intracellularly in biological systems. The origins of the GTPase
switch appear to be almost as ancient as life itself, and through
evolution nature has adapted this switch to a variety of purposes.
In this two-volume work a broad survey of the major classes of
GTPases is presented. The role of GTPases in ensuring accuracy
during protein translation, a new look at the trimeric G-protein
cycle, the molecular function of ARF in vesicle coating, the
emerging role of the dynamin family in vesicle transfer, GTPases
which activate GTPases during nascent protein translocation, and
the many roles of ras-related proteins in growth, cytoskeletal
polymerization, and vesicle transfer, are all described in 80
chapters by the leading authorities in their fields. Both detailed
knowledge of specific systems or proteins and general principles of
structure and function are offered. Much of this information has
never been published before. At the rate the extended family of
GTPases is growing it becomes increasingly unlikely that we will
again get it to sit for a group portrait such as this. Therefore,
the volume has the chance to become "the" reference work for
GTPases.
The purpose of the present volume, the first of two on the
pharmacology, biochemistry, and physiology of cyclic nucleotides,
is to provide a comprehensive and up-to-date anthology on the
nature and role of these important chemical regulators. Each of the
chapters is the work of internationally known researchers who
present a lucid and detailed review of their subject and not merely
a single laboratory's viewpoint. The chapters emphasize critical
assessments of the field rather than mere listings of experimental
findings. By so doing, the contributors present the role of cyclic
nucleotides in relationship to other intracellular regulators. Each
chapter begins with a detailed summary to allow the reader to
obtain a rapid overview of subsequent material. In addition, there
are extensive bibliographies and a detailed subject index. Wherever
pertinent, the chapters contain sections on drug mechanisms,
physiological relevance, and disease processes. The Volume is
divided into two sections, each beginning with an overview written
by Professors T. W. RALL and P. GREENGARD, respectively. The first
section focuses on the detailed pharmacology and chemistry of
cyclic nucleotides, including their formation, degradation,
measurement, and interaction with various modulatory agents, such
as receptors and calcium. The second section is concerned with the
biochemistry of protein phosphorylation, a process which appears to
be one of the most important mechanisms for the intracellular
expression of cyclic nucleotide action in eukaryotic cells.
Multiple Sclerosis (MS) is an inflammatory, often progressive, and
potentially disabling disease of the central nervous system. Onset
of disease is usually between the ages of 15 and 50, with the
incidence nearly twice as high in women. While the cause of MS is
still unknown, the predominant theory is that it is an autoimmune
disease, triggered by an unknown environmental factor that results
in both loss of central nervous system myelin and degeneration of
axons and neurons. Although there have been a number of
publications addressing different aspects of MS treatment in the
neurological literature, there is a dearth of material on MS
designed for internists and primary care physicians, who are often
the first to see patients presenting with symptoms of MS.
Therefore, this concise, clinically focused volume will serve as a
valuable resource tailored to the specific needs of internists and
primary care physicians. Part of the Oxford Neurology Library, this
highly practical pocketbook covers current approaches and new
developments in the diagnosis, treatment and management of MS,
including both early and advanced stages of the disease. The book
offers in-depth coverage of special populations, as well as the
more unusual manifestations of MS, which are less familiar to the
internal medicine audience. It will also address the role of
imaging studies in the diagnosis, differential diagnosis and
monitoring of the progression of MS. In addition to providing
up-to-date information on pharmacological therapies for MS, the
book also describes an array of non-pharmacological treatment
options.
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