This book constitutes the proceedings of the 22nd International Conference on Coordination Models and Languages, COORDINATION 2020, which was due to be held in Valletta, Malta, in June 2020, as part of the 15th International Federated Conference on Distributed Computing Techniques, DisCoTec 2020. The conference was held virtually due to the COVID-19 pandemic. The 12 full papers and 6 short papers included in this volume were carefully reviewed and selected from 30 submissions. They are presented in this volume together with 2 invited tutorials and 4 tool papers. The papers are organized in the following topical sections: tutorials; coordination languages; message-based communication; communications: types & implementations; service-oriented computing; large-scale decentralized systems; smart contracts; modelling; verification & analysis.