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100 years of Human Chorionic Gonadotropin: Reviews and New
Perspectives is a collection of articles written by some of the
world's leading experts on the pregnancy hormone and cancer marker
hCG. In 2019 it is difficult to ignore the effect that our
understanding of hCG has had on the lives of millions of people
worldwide. The hCG immunoassay, in one form or another, is now one
of the most common medical tests conducted and is often the first
indication that a mother-to-be is pregnant. Not only a marker of
pregnancy, hCG is utilized in the diagnosis and monitoring in
oncology and presents a potential target for novel cancer
therapeutics. 100 years ago, in 1919, Hirose was demonstrating
gonadotropic functions which resulted from a chorionic factor. Over
the last century this factor has become defined as hCG and more
recently explored as not one molecule but a group of molecules with
variable structure and variable functions in both pregnancy and
cancer. hCG is a multi-faceted molecule that has clinical and
therapeutic implications but can be a challenging topic for
researchers and physicians alike. This text covers the different
structures and functions of hCG exploring the genes and evolution
of the molecule, the different protein and glycosylation structures
which can exist and their effect on structure, detection and
quantification. 100 Years of hCG is not an attempt to recount the
history of every publication on hCG, but rather a collection of
reviews and new perspectives by "hCG-ologists", the term used by
Hussa to describe biochemists working on HCG in the first book
written on the topic over 30 years ago. Some of the authors have
been around a while, some not so long, but others are just
beginning their journey with a most beguiling molecule.
Human Physiology, Biochemistry and Basic Medicine is a unique
perspective that draws together human biology, physiology,
biochemistry, nutrition, and cell biology in one comprehensive
volume. In this way, it is uniquely qualified to address the needs
of the emerging field of humanology, a holistic approach to
understanding the biology of humans and how they are distinguished
from other animals. Coverage starts with human anatomy and
physiology and the details of the workings of all parts of the male
and female body. Next, coverage of human biochemistry and how
sugars, fats, and amino acids are made and digested is discussed,
as is human basic medicine, covering the science of diseases and
human evolution and pseudo-evolution. The book concludes with
coverage of basic human nutrition, diseases, and treatments, and
contains broad coverage that will give the reader an understanding
of the entire human picture.
Human chorionic gonadotropin (hCG) is produced during pregnancy by
the embryo. It promotes progesterone production by corpus luteal
cells. It also functions in pregnancy to promote angiogenesis in
uterine vasculature, it immuno-blands the invading placental tissue
so it is not rejected by the maternal uterine tissues, promotes the
growth of the uterus in line with the growth of the fetus, promotes
the differentiation of growing cytotrophoblast cells, promotes the
quiescence of contractions in the uterine myometrium during the
course of pregnancy, and also has function in growth and
development of fetal organs. The first edition described the
detailed biology, clinical chemistry, and clinical perspectives of
hCG and associated molecules, and examines hCG, hyperglycosylated
hCG and hCG free ss-subunit, 3 separate and independent molecules
with totally sovereign physiological functions. The second edition
will include coverage of the many new discoveries that have been
made in the last five years: hCG analogues may be the actual
driving signal of all human cancers. The editor estimates that 40%
of the out of date material will be excluded and replaced with 40%
of the exciting new findings. The book will also have a much
clearer pregnancy and cancer focus.
Biology of Life: Biochemistry, Physiology and Philosophy provides
foundational coverage of the field of biochemistry for a different
angle to the traditional biochemistry text by focusing on human
biochemistry and incorporating related elements of evolution to
help further contextualize this dynamic space. This unique approach
includes sections on early human development, what constitutes
human life, and what makes it special. Additional coverage on the
differences between the biochemistry of prokaryotes and eukaryotes
is also included. The center of life in prokaryotes is considered
to be photosynthesis and sugar generation, while the center of life
in eukaryotes is sugar use and oxidative phosphorylation. This
unique reference will inform specialized biochemistry courses and
researchers in their understanding of the role biochemistry has in
human life.
Human Gonadotropins is a must-have reference for basic science
researchers looking to maximize their knowledge in this specific
field of study. Luteinizing hormone, follicle-stimulating hormone,
and human chorionic gonadotropin are essential for reproduction and
outlined in detail in this work, covering topics ranging from
antibodies and immunoassays, to commercial products and standards,
genetics, and receptors and intermediaries for gonadotropins. Dr.
Laurence Cole has been recognized for his outstanding research
throughout his illustrious career. He has received awards from the
Institute for Anticancer Research, Biannual Prize for best
research; American Association for Clinical Chemistry, Most
Outstanding Research Contributor to Clinical Chemistry Prize;
Gynecology Oncology, Outstanding Speaker Award; and International
Society for Study of Trophoblastic Disease, Gold Medal for most
outstanding research. This detailed resource compiles all the
recent research together into one volume, with one consistent
voice.
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Glycopeptins (Hardcover)
Laurence A. Cole
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R4,786
R3,845
Discovery Miles 38 450
Save R941 (20%)
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Ships in 12 - 17 working days
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The concept of glycopeptins all started off as part of a bug hunt.
It started off with the observation that from 70 recent obstetrics
and gynaecology and reproductive biology books, they all only cite
hCG as just a promoter of corpus luteal progesterone, a 1920s
finding, and ignore the hundreds of more recent findings. Confirmed
and double confirmed science shows that hCG is a molecule with at
least 12 important functions in pregnancy. That hCG is not one
molecule but a group of five independent substances. These are hCG,
hyperglycosylated hCG, sulphated hCG, hyperglycosylated hCG free
subunit and foetal hCG. Each being structurally slightly different,
and each having separate biological functions. If a single
principal function had to be attributed to the hCG group of
molecules, it was surely constructing and running placental
hemochorial placentation, the process whereby a mother feeds a
foetus. And this process has nothing to do with the female gonad or
ovary. How 70 major obstetrics and gynaecology books and
reproductive books all claimed that hCG's sole job was promoting
ovarian corpus luteal progesterone production was misinformation,
it was a sin. The hCG group of molecules has many critical
functions in the placenta, foetus, uterus, gonads and in human
cancer cells. Here these 70 books were, wrongly teaching medical
students, medical residents, and graduate students, very out of
date garbage. What compounded this garbage was the name human
chorionic gonadotropin. Chorionic Gonadotropin meaning placenta
gonad hormone or placenta gonad promoter. Clearly, gonad
stimulation, or promotion of ovarian progesterone production was
not the principal function of this hormone.
This book covers human female biology, how the menstrual cycle is
controlled, how steroidogenesis is controlled and how the follicle
and the egg are formed. This book covers male biology, and how
steroid hormones are made, and how sperm are synthesised and
matured. Then this book covers sex biology, such as how the brain
deals with libido and sexual images, and how the brain controls
erection and ejaculation. This book deals with how sperm are
matured upon intercourse, how fertilisation takes place, and how
the fertilised embryo is matured and implants in the uterus. The
subjects of sexuality and homosexuality, chromosome disorders and
hydatidiform moles are carefully discussed and considered. Sexual
maturation of the foetus during pregnancy is carefully considered.
This book carefully describes puberty, adrenarche and menarche. The
subject of menopause is carefully considered. The subject of major
bacterial and viral and sexual diseases is carefully considered as
is the subject of reproductive cancers. In writing this book, care
has been taken to update everything and check out the information
available on medline and on the internet. This is a textbook for
undergraduates, medical students and graduates describing all the
details of human reproduction. It is also the only up-to-date book
on the market. Having examined a total 70 books on human
reproduction, obstetrics and gynaecology, they all, with no
exceptions, include mostly out-of-date science. This is corrected
in this book. This book is also a monograph for reproductive
biology scientists, covering all the most recent findings in this
field. It can also be sold as a general obstetrics and gynaecology
information source for use by physicians, the general public and in
libraries. This is a unique one-of-a-kind reference on human
reproduction.
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