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In the past two decades, pain research has become one of the most rapidly growing areas of neuroscience activity. Methods in Pain Research brings together in a single volume a survey of the methods that can be used to study a reaction or 'sensory report' in humans that can only be inferred by indirect means in animal or tissues studies. It presents source material, useful advice, and guidance to specific details as well as examples of current usage.
With each topic presented by one or more of the leading experts in the field, it examines the major modern techniques used in studying pain, including gene linkage, brain imaging methods, the use of transgenic rodent models, painful sensory neuropathy models, and more. The material also covers conventional methods of pain study, such as anatomical and electophysiological techniques. Methods in Pain Research provides up-to-date methodology and a guide to the strategies of experimental design.
One of the Most Rapidly Advancing Fields in Modern Neuroscience The
success of molecular biology and the new tools derived from
molecular genetics have revolutionized pain research and its
translation to therapeutic effectiveness. Bringing together recent
advances in modern neuroscience regarding genetic studies in mice
and humans and the practicality of clinical trials, Translational
Pain Research: From Mouse to Man effectively bridges the gap
between basic research and patient care by humanely examining
rodent models for pain associated with bone cancer, osteoarthritis,
fibromyalgia, and cardiac episodes. Distinguished Team of
International Contributors In addition to addressing the
groundbreaking technical advances in tract tracing,
endocannabinoids, cannabis, gene therapy, siRNA gene studies, and
the role of glia, cytokines, P2X receptors and ATP, this book also
presents cutting-edge information on: Nociceptor sensitization
Muscle nociceptors and metabolite detection Visceral afferents in
disease Innovative rodent model for bone cancer pain Highly
specific receptor cloning Modular molecular mechanisms relevant to
painful neuropathies This sharply focused work also discusses
unexpected discoveries derived from brain-imaging studies related
to thalamic pain. Translational Pain Research covers the progress
made toward bringing laboratory science (much of it at the
molecular level) to our understanding of pain phenomena in humans,
with the ultimate goal of reducing the suffering that often
accompanies pain and its indirect consequences.
In the past two decades, pain research has become one of the most
rapidly growing areas of neuroscience activity. Methods in Pain
Research brings together in a single volume a survey of the methods
that can be used to study a reaction or 'sensory report' in humans
that can only be inferred by indirect means in animal or tissues
studies. It presents source material, useful advice, and guidance
to specific details as well as examples of current usage. With each
topic presented by one or more of the leading experts in the field,
it examines the major modern techniques used in studying pain,
including gene linkage, brain imaging methods, the use of
transgenic rodent models, painful sensory neuropathy models, and
more. The material also covers conventional methods of pain study,
such as anatomical and electophysiological techniques. Methods in
Pain Research provides up-to-date methodology and a guide to the
strategies of experimental design.
Advances in the area of tactile perception and pain have lead to
the development of this text on basic research and clinical
practice. Equal parts psychology and neuroscience, it covers
peripheral cutaneous tactile information processing, sensory
mapping, tactile exploratory behaviour, neurophysiology of
nociception and nociceptors in pain research, clinical scaling
methods for psychophysics of pain, and pain control, pathology, and
therapeutics. Detailed chapters discuss how the brain processes
both pain and touch, the nerve pathways by which these sensations
travel, how sensations of pain can be clinically measured, and
means of controlling pathological pain.
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