Bioinformatics is growing by leaps and bounds; theories/algorithms/statistical techniques are constantly evolving. Nevertheless, a core body of algorithmic ideas have emerged and researchers are beginning to adopt a "problem solving" approach to bioinformatics, wherein they use solutions to well-abstracted problems as building blocks to solve larger scope problems.

"Problem Solving Handbook for Computational Biology" and Bioinformatics is an edited volume contributed by world renowned leaders in this field. This comprehensive handbook with problem solving emphasis, covers all relevant areas of computational biology and bioinformatics. Web resources and related themes are highlighted at every opportunity in this central easy-to-read reference.

Designed for advanced-level students, researchers and professors in computer science and bioengineering as a reference or secondary text, this handbook is also suitable for professionals working in this industry.

Graph Separators with Applications is devoted to techniques for obtaining upper and lower bounds on the sizes of graph separators - upper bounds being obtained via decomposition algorithms. The book surveys the main approaches to obtaining good graph separations, while the main focus of the book is on techniques for deriving lower bounds on the sizes of graph separators. This asymmetry in focus reflects our perception that the work on upper bounds, or algorithms, for graph separation is much better represented in the standard theory literature than is the work on lower bounds, which we perceive as being much more scattered throughout the literature on application areas. Given the multitude of notions of graph separator that have been developed and studied over the past (roughly) three decades, there is a need for a central, theory-oriented repository for the mass of results. The need is absolutely critical in the area of lower-bound techniques for graph separators, since these techniques have virtually never appeared in articles having the word separator' or any of its near-synonyms in the title. Graph Separators with Applications fills this need.

Computation theory is a discipline that uses mathematical concepts and tools to expose the nature of "computation" and to explain a broad range of computational phenomena: Why is it harder to perform some computations than others? Are the differences in difficulty that we observe inherent, or are they artifacts of the way we try to perform the computations? How does one reason about such questions? This unique textbook strives to endow students with conceptual and manipulative tools necessary to make computation theory part of their professional lives. The work achieves this goal by means of three stratagems that set its approach apart from most other texts on the subject. For starters, it develops the necessary mathematical concepts and tools from the concepts' simplest instances, thereby helping students gain operational control over the required mathematics. Secondly, it organizes development of theory around four "pillars," enabling students to see computational topics that have the same intellectual origins in physical proximity to one another. Finally, the text illustrates the "big ideas" that computation theory is built upon with applications of these ideas within "practical" domains in mathematics, computer science, computer engineering, and even further afield. Suitable for advanced undergraduate students and beginning graduates, this textbook augments the "classical" models that traditionally support courses on computation theory with novel models inspired by "real, modern" computational topics,such as crowd-sourced computing, mobile computing, robotic path planning, and volunteer computing. Arnold L. Rosenberg is Distinguished Univ. Professor Emeritus at University of Massachusetts, Amherst, USA. Lenwood S. Heath is Professor at Virgina Tech, Blacksburg, USA.

Computation theory is a discipline that uses mathematical concepts and tools to expose the nature of "computation" and to explain a broad range of computational phenomena: Why is it harder to perform some computations than others?  Are the differences in difficulty that we observe inherent, or are they artifacts of the way we try to perform the computations?  How does one reason about such questions? This unique textbook strives to endow students with conceptual and manipulative tools necessary to make computation theory part of their professional lives. The work achieves this goal by means of three stratagems that set its approach apart from most other texts on the subject. For starters, it develops the necessary mathematical concepts and tools from the concepts' simplest instances, thereby helping students gain operational control over the required mathematics. Secondly, it organizes development of theory around four "pillars," enabling students to see computational topics that have the same intellectual origins in physical proximity to one another. Finally, the text illustrates the "big ideas" that computation theory is built upon with applications of these ideas within "practical" domains in mathematics, computer science, computer engineering, and even further afield. Suitable for advanced undergraduate students and beginning graduates, this textbook augments the "classical" models that traditionally support courses on computation theory with novel models inspired by "real, modern" computational topics,such as  crowd-sourced computing, mobile computing, robotic path planning, and volunteer computing. Arnold L. Rosenberg is Distinguished Univ. Professor Emeritus at University of Massachusetts, Amherst, USA. Lenwood S. Heath is Professor at Virgina Tech, Blacksburg, USA.            

Bioinformatics is growing by leaps and bounds; theories/algorithms/statistical techniques are constantly evolving. Nevertheless, a core body of algorithmic ideas have emerged and researchers are beginning to adopt a "problem solving" approach to bioinformatics, wherein they use solutions to well-abstracted problems as building blocks to solve larger scope problems. Problem Solving Handbook for Computational Biology and Bioinformatics is an edited volume contributed by world renowned leaders in this field. This comprehensive handbook with problem solving emphasis, covers all relevant areas of computational biology and bioinformatics. Web resources and related themes are highlighted at every opportunity in this central easy-to-read reference. Designed for advanced-level students, researchers and professors in computer science and bioengineering as a reference or secondary text, this handbook is also suitable for professionals working in this industry.

Graph Separators with Applications is devoted to techniques for obtaining upper and lower bounds on the sizes of graph separators - upper bounds being obtained via decomposition algorithms. The book surveys the main approaches to obtaining good graph separations, while the main focus of the book is on techniques for deriving lower bounds on the sizes of graph separators. This asymmetry in focus reflects our perception that the work on upper bounds, or algorithms, for graph separation is much better represented in the standard theory literature than is the work on lower bounds, which we perceive as being much more scattered throughout the literature on application areas. Given the multitude of notions of graph separator that have been developed and studied over the past (roughly) three decades, there is a need for a central, theory-oriented repository for the mass of results. The need is absolutely critical in the area of lower-bound techniques for graph separators, since these techniques have virtually never appeared in articles having the word 'separator' or any of its near-synonyms in the title. Graph Separators with Applications fills this need.