This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-S-transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets. Key selling features: Summarizing the way glutathione is involved in stress responses Compiling the multiple ways glutathione affects inflammatory responses Disclosing how glutathione dampens programmed cell death such as ferroptosis Exploring the enigma of how enzymes accelerate glutathione-dependent processes Discussing how detoxification and redox regulation is mediated by glutathionylation Reviewing the ways glutaredoxins catalyze protein disulfide reduction Highlighting the medical impact of glutathione-related metabolic pathways Illustrating the role thiol metabolism of pathogens might play in drug discovery

Understanding the molecular basis of complex biological processes has been a major goal of biological chemistry from early on. Inflammation is one such entity, and recent years have seen exciting progress in the under- standing of molecular interactions; there has been a long way from dolor, rubor, calor, and tumor as a fundamental description of the phenomenon to current knowledge, e.g., on the control of the respiratory burst of the granulocyte, the atomic details of protease regulation, or the interaction of cytokines. We were glad to have been given the opportunity by the Gesellschaft fUr Biologische Chemie to call upon experts in this bustling field of research for this Colloquium. The sessions were organized in the order of increasing complexity, starting with the key phenomena of the inflamma- tory response and its modulation by cytokines to intravascular events and shock and sepsis; thus, the current attempts to apply basic knowledge on mediators of inflammation to the clinical situation were also considered. In-depth chapters presenting the state of the art in these areas are collected in this book, and we thank the authors for their efforts. We also thank the Chairmen of the sessions, Profs. C. Sorg (Munster), D. Roos (Amsterdam), S. Bhakdi (Mainz), H. J. Muller-Eberhard (Hamburg), H. G. Schwick (Marburg), K. Resch (Hannover), W. Schaper (Bad Nauheim), D. Keppler (Heidelberg), and O. Trentz (Zurich) for their input, and it is a great pleasure to acknowledge the support by Drs.

This book contains a broad survey on the peroxiredoxins. It involves almost all groups that contributed significant insights into the emerging field. Coverage discusses the diverse biological roles of the new protein family in the context of other antioxidant systems like those based on heme or selenium catalysis. In addition, the book highlights related future perspectives.

This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-S-transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets. Key selling features: Summarizing the way glutathione is involved in stress responses Compiling the multiple ways glutathione affects inflammatory responses Disclosing how glutathione dampens programmed cell death such as ferroptosis Exploring the enigma of how enzymes accelerate glutathione-dependent processes Discussing how detoxification and redox regulation is mediated by glutathionylation Reviewing the ways glutaredoxins catalyze protein disulfide reduction Highlighting the medical impact of glutathione-related metabolic pathways Illustrating the role thiol metabolism of pathogens might play in drug discovery