This is the first serious attempt to synthesize all that became
known of glutathione over the last three decades. The book contains
an update of glutathione biosynthesis with special emphasis on its
regulation in adaptive stress responses. Other chapters review
glutathione transport systems and glutathione peroxidases and their
differences in substrate specificities and localization. Further
contributions center on the diversified roles of different
glutathione-S-transferases and the roles of nitrosoglutathione and
glutaredoxins - a subfamily of redoxins. The book closes with
discussions of the analogous or homologous thiol metabolism in
pathogens and the potential suitability of involved enzymes as drug
targets. Key selling features: Summarizing the way glutathione is
involved in stress responses Compiling the multiple ways
glutathione affects inflammatory responses Disclosing how
glutathione dampens programmed cell death such as ferroptosis
Exploring the enigma of how enzymes accelerate
glutathione-dependent processes Discussing how detoxification and
redox regulation is mediated by glutathionylation Reviewing the
ways glutaredoxins catalyze protein disulfide reduction
Highlighting the medical impact of glutathione-related metabolic
pathways Illustrating the role thiol metabolism of pathogens might
play in drug discovery
General
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