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Easy to read and use, Addiction Psychiatric Medicine: A
Comprehensive Board Review provides a systematic and comprehensive
review of all diseases and disorders frequently tested on addiction
psychiatry and addiction medicine board examinations. This
high-yield manual is divided into two sections: the first section
contains short chapters covering important topics in addiction
medicine and psychiatry, including alcohol, sedatives, opioids,
tobacco, cannabis, and stimulants; the second section divides
questions into three 50-question blocks to resemble the board exam
format. This learning tool is essential for exam study in addiction
psychiatry or addiction medicine and an excellent resource for
interacting with patients with substance abuse disorders. Includes
close to 300 multiple choice questions and detailed answer
explanations Presents information on clinical concepts, etiologies
of diseases, treatments, and preventive measures in a format that's
easy to remember and apply, with tables and clinical points.
Includes commonly missed concepts on exams for addiction psychiatry
and addiction medicine to help users achieve optimal sores. Offers
quick access to high-yield content critical for success on board
exams, clinical clerkships, and medical practice. Enhanced eBook
version included with purchase. Your enhanced eBook allows you to
access the question bank, plus all of the text, figures, and
references from the book on a variety of devices.
The field of antibody engineering has become a vital and integral
part of making new, improved next generation therapeutic monoclonal
antibodies, of which there are currently more than 300 in clinical
trials across several therapeutic areas. Therapeutic antibody
engineering examines all aspects of engineering monoclonal
antibodies and analyses the effect that various genetic engineering
approaches will have on future candidates. Chapters in the first
part of the book provide an introduction to monoclonal antibodies,
their discovery and development and the fundamental technologies
used in their production. Following chapters cover a number of
specific issues relating to different aspects of antibody
engineering, including variable chain engineering, targets and
mechanisms of action, classes of antibody and the use of antibody
fragments, among many other topics. The last part of the book
examines development issues, the interaction of human IgGs with
non-human systems, and cell line development, before a conclusion
looking at future issues affecting the field of therapeutic
antibody engineering.
Goes beyond the standard engineering issues covered by most books
and delves into structure-function relationshipsIntegration of
knowledge across all areas of antibody engineering, development,
and marketingDiscusses how current and future genetic engineering
of cell lines will pave the way for much higher productivity
Rural-Urban Water Struggles compiles diverse analyses of
rural-urban water connections, discourses, identities and struggles
evolving in the context of urbanization around the world. Departing
from an understanding of urbanization as a process of constant
making and remaking of multi-scalar territorial interactions that
extend beyond traditional city boundaries and that deeply
reconfigure rural-urban hydrosocial territories and interlinkages,
the chapters demonstrate the need to reconsider and trouble the
rural-urban dichotomy. The contributors scrutinize how existing
approaches for securing urban water supply - ranging from water
transfers to payments for ecosystem services - all rely on a myriad
of techniques: they are produced by, and embedded in, specific
institutional and legal arrangements, actor alliances, discourses,
interests and technologies entwining local, regional and global
scales. The different chapters show the need to better understand
on-the-ground realities, taking account of inequalities in water
access and control, as well as representation and
cultural-political recognition among rural and urban subjects.
Rural-Urban Water Struggles will be of great use to scholars of
water governance and justice, environmental justice and political
ecology. This book was originally published as a special issue of
Water International.
This unique volume reviews the beautiful architectures and varying
mechanical actions of the set of specialized cellular proteins
called molecular chaperones, which provide essential kinetic
assistance to processes of protein folding and unfolding in the
cell. Ranging from multisubunit ring-shaped chaperonin and Hsp100
machines that use their central cavities to bind and
compartmentalize action on proteins, to machines that use other
topologies of recognition - binding cellular proteins in an archway
or at the surface of a 'clamp' or at the surface of a globular
assembly - the structures show us the ways and means the cell has
devised to assist its major effectors, proteins, to reach and
maintain their unique active forms, as well as, when required, to
disrupt protein structure in order to remodel or degrade. Each type
of chaperone is beautifully illustrated by X-ray and EM structure
determinations at near- atomic level resolution and described by a
leader in the study of the respective family. The beauty of what
Mother Nature has devised to accomplish essential assisting actions
for proteins in vivo is fully appreciable.
The litany of alarming observations about water use and misuse is
now familiar-over a billion people without access to safe drinking
water; almost every major river dammed and diverted; increasing
conflicts over the delivery of water in urban areas; continuing
threats to water quality from agricultural inputs and industrial
wastes; and the increasing variability of climate, including
threats of severe droughts and flooding across locales and regions.
These issues present tremendous challenges for water governance.
This book focuses on three major concepts and approaches that have
gained currency in policy and governance circles, both globally and
regionally-scarcity and crisis, marketization and privatization,
and participation. It provides a historical and contextual overview
of each of these ideas as they have emerged in global and regional
policy and governance circles and pairs these with in-depth case
studies that examine manifestations and contestations of water
governance internationally. The book interrogates ideas of water
crisis and scarcity in the context of bio-physical, political,
social and environmental landscapes to better understand how ideas
and practices linked to scarcity and crisis take hold, and become
entrenched in policy and practice. The book also investigates ideas
of marketization and privatization, increasingly prominent features
of water governance throughout the global South, with particular
attention to the varied implementation and effects of these
governance practices. The final section of the volume analyzes
participatory water governance, querying the disconnects between
global discourses and local realities, particularly as they
intersect with the other themes of interest to the volume.
Promoting a view of changing water governance that links across
these themes and in relation to contemporary realities, the book is
invaluable for students, researchers, advocates, and policy makers
interested in water governance challenges facing the developing
world.
Rural-Urban Water Struggles compiles diverse analyses of
rural-urban water connections, discourses, identities and struggles
evolving in the context of urbanization around the world. Departing
from an understanding of urbanization as a process of constant
making and remaking of multi-scalar territorial interactions that
extend beyond traditional city boundaries and that deeply
reconfigure rural-urban hydrosocial territories and interlinkages,
the chapters demonstrate the need to reconsider and trouble the
rural-urban dichotomy. The contributors scrutinize how existing
approaches for securing urban water supply - ranging from water
transfers to payments for ecosystem services - all rely on a myriad
of techniques: they are produced by, and embedded in, specific
institutional and legal arrangements, actor alliances, discourses,
interests and technologies entwining local, regional and global
scales. The different chapters show the need to better understand
on-the-ground realities, taking account of inequalities in water
access and control, as well as representation and
cultural-political recognition among rural and urban subjects.
Rural-Urban Water Struggles will be of great use to scholars of
water governance and justice, environmental justice and political
ecology. This book was originally published as a special issue of
Water International.
"Put on your hiking shoes, pack your binoculars, and rediscover the
City of Angels." --Westways Magazine Los Angeles may have a
reputation as a concrete jungle, but in reality, it's full of
amazing wildlife. You just need to know where to find it! Equal
parts natural history, field guide, and trip planner, Wild LA has
something for everyone. It looks at the factors that shape local
nature--including fire, floods, and climate--and profiles over 100
local species, from easy-to-spot squirrels and praying mantids to
more elusive green sea turtles, bighorn sheep, and mountain lions.
Also included are descriptions of day trips that help you explore
natural wonders on hiking trails, in public parks, and in your own
backyard.
Infections caused by fungi have recently attracted the attention of
both clinicians and basic researchers given the heavy burden they
represent for any health system. The mortality and morbidity rates
associated to mycosis are progressively rising simply because some
of these diseases are still neglected by health-care workers and
due to the changing sensitivity to antifungal drugs displayed by
these organisms. In this book, both researchers and clinicians
working in the medical mycology field explore the most recent
literature about specific mycosis; placing in one concise chapter
thoroughly revisions of the current knowledge on virulence factors,
recognition by immune cells, immunoevasion, epidemiology, new
diagnosis trends and therapeutics. This book is recommended to
researchers, physicians and students interested in medical
mycology.
The litany of alarming observations about water use and misuse is
now familiar-over a billion people without access to safe drinking
water; almost every major river dammed and diverted; increasing
conflicts over the delivery of water in urban areas; continuing
threats to water quality from agricultural inputs and industrial
wastes; and the increasing variability of climate, including
threats of severe droughts and flooding across locales and regions.
These issues present tremendous challenges for water governance.
This book focuses on three major concepts and approaches that have
gained currency in policy and governance circles, both globally and
regionally-scarcity and crisis, marketization and privatization,
and participation. It provides a historical and contextual overview
of each of these ideas as they have emerged in global and regional
policy and governance circles and pairs these with in-depth case
studies that examine manifestations and contestations of water
governance internationally. The book interrogates ideas of water
crisis and scarcity in the context of bio-physical, political,
social and environmental landscapes to better understand how ideas
and practices linked to scarcity and crisis take hold, and become
entrenched in policy and practice. The book also investigates ideas
of marketization and privatization, increasingly prominent features
of water governance throughout the global South, with particular
attention to the varied implementation and effects of these
governance practices. The final section of the volume analyzes
participatory water governance, querying the disconnects between
global discourses and local realities, particularly as they
intersect with the other themes of interest to the volume.
Promoting a view of changing water governance that links across
these themes and in relation to contemporary realities, the book is
invaluable for students, researchers, advocates, and policy makers
interested in water governance challenges facing the developing
world.
The marmosets and callimicos are diminutive monkeys from the Amazon
basin and Atlantic Coastal Forest of South America. The marmosets
are the smallest anthropoid primates in the world, ranging in size
from approximately 100 to 350 g (Hershkovitz 1977; Soini 1988; Ford
and Davis 1992; Araujo et al. 2000); calli- cos are not much
bigger, at around 350-540 g (Ford and Davis 1992; Encarnacion and
Heymann 1998; Garber and Leigh 2001). Overwhelming genetic
evidence, from both nuclear and mitochondrial DNA, now indicates
that these taxa represent a unified clade within the callitrichid
radiation of New World monkeys, a finding that was unthinkable to
all but a few geneticists a decade ago (see review in Cortes-
Ortiz, this volume Chap. 2). With increasing evidence that the
earliest anthropoids were themselves small bodied (under the 0. 8-1
kg threshold that marks all other living anthropoids; see Ross and
Kay 2004), the ecology, behavior, reproductive stresses, and
anatomical adaptations of the marmosets and callimicos provide the
best living models with which to assess the types of adaptations
that may have characterized early anthropoids. When Anthony
Rylands' Marmosets and Tamarins: Systematics, Behaviour and Ecology
was published in 1993, contributions focused almost entirely on
tamarins due to the scarcity of data on marmoset behavior and the
almost total lack of kno- edge about the enigmatic callimicos.
Fortunately, this has changed (see Fig. 1).
This volume represents a comprehensive examination of the newly
recognized callimico/marmoset clade, which includes the smallest
anthropoid primates on earth. It will explore these diminutive
primates in their entirety, with sections on phylogeny, taxonomy
and functional anatomy, behavioral ecology, reproductive
physiology, as well as address critical conservation issues and the
need for conservation action. The topics specifically selected for
this volume are pivotal for understanding the evolutionary
adaptations and divergence of any primate group, and especially one
as diverse and curious as this. The discoveries of new taxa over
the last fifteen years along with new genetic data have transformed
this group from three genera (one with only a distant relationship
to the others) and five recognized species, to five closely related
genera, comprising at least 22 species. This volume will be the
first to synthesize data on these newly recognized taxa.
This volume is an international endeavor, bringing together
primary callimico and marmoset researchers from around the globe,
including Brazil and the United States as well as Greece, Italy,
Switzerland, and Germany. One of the merits of this volume is that
it will serve as a readily accessible work that includes the major
findings of several key international researchers whose work has
not been easily available to English-speaking scholars. In
addition, it draws together lab and field researchers, geneticists,
anatomists, and behaviorists in an integrated volume that will
provide the most detailed and thorough work on either callimicos or
marmosets to date. This volume will also provide a timely forum for
identifying future avenues of action necessary for more fully
understanding and protecting this intriguing primate radiation.
They said that in her youth, Annabelle had long, coal black hair,
high cheekbones, and deep, penetrating, brown eyes. Her eyes could
still penetrate the soul, but they were paler in color, maybe
because they were covered with the whitish film of cataracts. I
remember watching her take her hair from the neat bun she wore and
let it down to comb. Her hair was long, but no longer black as
coal. It was the color of newly formed storm clouds and fell in a
silvery braid to her hips. I watched her comb it out and then she
would braid it, wind it back into a bun and pin it low, just above
the nape of her neck. Everyone always said that I favored her a
lot. Annabelle was my great-grandmother; she was a Full Blood, a
Choctaw Indian from Savannah, Georgia. When a child, I thought she
was tall, larger than life. My admiration of her as we walked in
the yard and I helped her gather eggs and pick flowers, was
unsurpassable; but as I grew, I realized that she was a tiny woman.
Shrunken from her many years on earth, she stood barely four feet,
ten inches tall. In her older years, maybe even her younger ones
too, she was never without a jar of Garrett snuff. One summer, when
I was about twelve years old, I went to stay with my grandmother
Annabelle. And because her house was so small, I slept in her
bedroom with her. Each night before we went to sleep, she pulled a
leather bound book from underneath her mattress and wrote for a few
minutes before she extinguished the bedside lamp. She seemed intent
on what she was doing so I did not bother her with questions, but
after several nights, curiosity got the better of me and when she
finished and placed the book under the mattress, I asked what she
was writing in the book. She told me that she was writing her
thoughts on the events of the day so that if she wanted she could
look back and know exactly what she was thinking and how she felt
that particular day. "Is that how you remember all of those stories
you tell me, about when you were a child and about your kinfolks
back then" I asked. "It is a part of it," she replied, "but some
things you just do not ever forget. They remain with you your
entire life." "Tell me a story, Grandmother," I begged. "Tell me
about when you were a child; a young girl like me." She began her
story that night, by telling me how she met and married my
grandfather Jesse. She also told me about leaving her home and
family in Savannah to move to Mobile to live near my grandfather's
family. And in that telling, I discovered that my grandmother had
led a very interesting life, especially in her earlier years. Her
life was filled with heartbreaks, heartaches, great times, and sad
times. She attended Mardi Gras Balls and traveled extensively
around the South. She was involved with an assortment of ill-fated
lovers. Indulged in hoodoo, voodoo, even murder Hers was a life I
found extremely fascinating; a life, I wished I could live. That
summer, I decided that when I grew old, I wanted to be just like my
grandmother Annabelle. However, today, as I sat staring across the
haphazard layer of hills to the west and thought of Annabelle and
the olden days of grace and charm. I realized that those days were
forever gone. They were days that I myself would never know, except
through my grandmother's eyes and memories. No longer that young
inquisitive girl, I am an old woman now. On my own, I have lived a
long uneventful life. Only through her stories could I live the
life I dreamt of; therefore, I decided to share her story with the
world. I am certain she would approve. I hope you all enjoy reading
her story, as much as I enjoyed writing it. Her story began April
1865, at the end of the Civil War, as was told to me by my
grandmother, Rebecca Annabelle Maples Foster.
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