SMART Vaccines - Strategic Multi-Attribute Ranking Tool for Vaccines - is a prioritization software tool developed by the Institute of Medicine that utilizes decision science and modeling to help inform choices among candidates for new vaccine development. A blueprint for this computer-based guide was presented in the 2012 report Ranking Vaccines: A Prioritization Framework: Phase I. The 2013 Phase II report refined a beta version of the model developed in the Phase I report. Ranking Vaccines: Applications of a Prioritization Software Tool: Phase III: Use Case Studies and Data Framework extends this project by demonstrating the practical applications of SMART Vaccines through use case scenarios in partnership with the Public Health Agency of Canada, New York State Department of Health, and the Serum Institute of India. This report also explores a novel application of SMART Vaccines in determining new vaccine product profiles, and offers practical strategies for data synthesis and estimation to encourage the broader use of the software. Table of Contents Front Matter Summary 1 Introduction: SMART Vaccines and Smart Priorities 2 Data Synthesis and Framework 3 Use Case Scenarios and Design Enhancements 4 Reflections and Looking Forward References Appendix A: Use Case Scenarios Report for SMART Vaccines Appendix B: Committee's Response to the Use Case Scenarios Report Appendix C: SMART Vaccines Software Updates Appendix D: Stakeholder Speakers Appendix E: Biographical Information

SMART Vaccines-Strategic Multi-Attribute Ranking Tool for Vaccines-is a prioritization software tool developed by the Institute of Medicine that utilizes decision science and modeling to help inform choices among candidates for new vaccine development. A blueprint for this computer-based guide was presented in the 2012 report Ranking Vaccines: A Prioritization Framework: Phase I. Ranking Vaccines: A Prioritization Software Tool,Phase II extends the proof-of-concept presented in the Phase I report, which was based on multi-attribute utility theory. This report refines a beta version of the model developed in the Phase I report and presents its next iteration, SMART Vaccines 1.0. Ranking Vaccines: Phase II discusses the methods underlying the development, validation, and evaluation of SMART Vaccines 1.0. It also discusses how SMART Vaccines should-and, just as importantly, should not-be used. The report also offers ideas for future enhancements for SMART Vaccines as well as for ideas for expanded uses and considerations and possibilities for the future. Table of Contents Front Matter Summary 1 Introduction: New Vaccines and SMART Vaccines 2 Refinements to the SMART Vaccines Model 3 Data Synthesis, Software Redesign, and Evaluation 4 Observations and Looking Forward References Appendix A: Computational Modeling for SMART Vaccines Appendix B: Candidate Disease Profiles Appendix C: Data Sources and Methodology for SMART Vaccines Appendix D: Verification and Analyses of the SMART Vaccines Computational Model Appendix E: Stakeholder Speakers Appendix F: Biographical Information

As a number of diseases emerge or reemerge thus stimulating new vaccine development opportunities to help prevent those diseases, it can be especially difficult for decision makers to know where to invest their limited resources. Therefore, it is increasingly important for decision makers to have the tools that can assist and inform their vaccine prioritization efforts. In this first phase report, the IOM offers a framework and proof of concept to account for various factors influencing vaccine prioritization-demographic, economic, health, scientific, business, programmatic, social, policy factors and public concerns. Ranking Vaccines: A Prioritization Framework describes a decision-support model and the blueprint of a software-called Strategic Multi-Attribute Ranking Tool for Vaccines or SMART Vaccines. SMART Vaccines should be of help to decision makers. SMART Vaccines Beta is not available for public use, but SMART Vaccines 1.0 is expected to be released at the end of the second phase of this study, when it will be fully operational and capable of guiding discussions about prioritizing the development and introduction of new vaccines. Table of Contents Front Matter Summary 1 Introduction: From Smallpox to SMART Vaccines 2 Modeling Strategy: From Single Attribute to Multiple Attributes 3 Data Evaluation and Software Development 4 Observations and Looking Forward References Appendix A: Mathematical Functions Appendix B: Candidate Disease Profiles and Data Appendix C: Stakeholder Speakers Appendix D: Biographical Information