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International Review of Cell and Molecular Biology reviews and
details current advances in cell and molecular biology. This most
current release in this highly cited series focuses on such timely
topics as novel treatments in immunotherapy in breast cancer,
chemokine receptor signaling and the hallmarks of cancer,
tumor-targeting antibodies, and a section on mitochondrion and
whether they are a common organelle for cell death. As always,
readers will find the articles in this series to be of great value,
with a high impact and average cited half-life of nine years. The
IRCMB series has a worldwide readership, maintaining a high
standard by publishing invited articles on important and timely
topics that are authored by prominent cell and molecular
biologists. This great resource ranks high amongst scientific
journals dealing with cell biology.
Biology of T Cells: Part A, Volume 341, the latest release in the
International Review of Cell and Molecular Biology, reviews and
details current advances in cell and molecular biology. The IRCMB
series maintains the highest standard by publishing timely topics
authored by prominent cell and molecular biologists. Specialized
topics in this release include TCR signaling: Molecules and
mechanisms, TCR diversity: Purpose and generation, Transcriptional
programs underlying T-cell differentiation and function, Surface
phenotypes of CD8+ and CD4+ T cells, Co-stimulation and
co-inhibition in CD8+ and CD4+ T cells, Regulated cell death and T
cells, Molecular mechanisms behind T-cell priming by DCs, and more.
International Review of Cell and Molecular Biology. Volume 336
reviews and details current advances in cell and molecular biology.
The IRCMB series has a worldwide readership, maintaining a high
standard by publishing invited articles on important and timely
topics that are authored by prominent cell and molecular
biologists. This updated volume includes specific chapters on
Membrane trafficking in autophagy, Targeting the metabolism of
leukemic cells, Autophagic flux in Alzheimer's disease,
Transcriptional alterations associated with celiac disease, and the
Regulation of antitumor immunity by IDO1, amongst other timely
topics. The articles published in IRCMB have a high impact and an
average cited half-life of 9 years. This great resource ranks high
amongst scientific journals dealing with cell biology.
Radiation Oncology and Radiotherapy, Part A, Volume 172 in the
Methods in Cell Biology series, highlights advances in the field,
with this new volume presenting interesting chapters on timely
topics, including DNA damage quantification by the COMET assay,
Immunofluorescence microscopy-assisted quantification of ATM and
ATR activation in irradiated cells, Immunoblotting-based
characterization of the DNA damage response, Assessment of lipid
peroxidation in irradiated cells, A simple method to assess
clonogenic survival of irradiated cancer cells, Quantification of
beta-galactosidase activity as a marker of radiation-driven
cellular senescence, Cytofluorometric assessment of cell cycle
progression in irradiated cells, and more. Other sections cover
Assessment of transcription inhibition as a characteristic of
immunogenic cell death, Assessment of eIF2a phosphorylation during
immunogenic cell death, Quantification of cytosolic DNA species by
immunofluorescence and automated image analysis, Flow
cytometry-assisted quantification of CALR exposure during
immunogenic cell death, Interference of immunogenic anticancer
therapy by artificially controlled calreticulin secretion from
tumor cells, along with many additional topics of interest.
DNA Damage and Chromosomal Instability, Volume 182 in the Methods
in Cell Biology series, highlights new advances in the field, with
this new volume presenting interesting chapters. Each chapter is
written by an international board of authors.
Celiac Disease, Volume 179 in the Methods in Cell Biology series is
composed of extensive protocols about novel and widely used
techniques for celiac disease research. Topics covered in this
volume include Pepsin trypsin digested gliadin treatment of
intestinal cells in vitro, Ex vivo Gliadin Stimulation of
Intestinal Cells, Measuring intestinal permeability in celiac
disease ex vivo using Ussing chambers, Intestinal permeability
assessment using lactulose and mannitol, In vivo sensitization to
gliadin by oral administration, Separation of epithelial and immune
cells from intestinal biopsy samples, Isolation and study of
dendritic cells and macrophages from human intestinal samples,
Gnobiotic mouse models to study gluten sensitivity, and more. Other
sections in this new release include In vitro differentiation of
macrophages from peripheral blood cells of celiac patients,
Assessment of activated gut-homing CD8+ T cells in blood by flow
cytometry during a three-day gluten challenge, Isolation,
cryopreservation and thawing of peripheral blood mononuclear cells
for downstream applications, and more.
Radiation Oncology and Radiotherapy Part C, Volume 180 in the
Methods in Cell Biology series, highlights advances in the field,
with this new volume presenting interesting chapters on timely
topics, including Image-guided Radiation Therapy of tumors in
preclinical models, Methods to preserve correct dosimetry in small
animal irradiators, Monitoring TGFbeta signaling in irradiated
tumors, Pipeline to characterize the TCR repertoire of irradiated
tumors, Pipeline to identify tumor neoantigens exposed by
radiation, Methods to assess abscopal responses in mice, Monitoring
the biodistribution of radiolabeled therapeutics in mice, and more.
Additional chapters cover Methods to assess radiation-induced
fibrosis in mice, Methods to assess radiation-induced
cardiotoxicity in mice, Histological assessment of intestinal
injury by radiation, Methods to investigate CNS involvement in
irradiated mice, Methods to characterize the exosomal output of
irradiated cancer cells, and more.
Viral Vectors in Cancer Immunotherapy, Volume 379 in the
International Review of Cell and Molecular Biology presents the
latest on cancer immunotherapy and how it has transformed cancer
treatment through advances in immune checkpoint inhibitors and
adoptive cell therapy. Chapters in this new release include Past,
present and future of viral vectors in cancer immunotherapy,
Alphaviruses in cancer immunotherapy, Adenoviral-based cancer gene
therapy, Armored modified vaccinia Ankara in cancer immunotherapy,
Strategies of Semliki Forest virus in immuno-oncology, Maraba virus
in cancer immunotherapy, Oncolytic viruses in hematological
malignancies, Oncolytic virus for cancer therapies: Overview and
future directions, and more. The use of genetically modified
viruses allows the expression of pro-inflammatory molecules, while
the immune system receives danger signals from the viruses
themselves. In some cases, the virus can also induce tumor cell
death. This book will review advances in virus-based cancer
immunotherapy in both solid tumors and hematologic malignancies.
Methods in Cancer Stem Cell Biology: Part B, Volume 171 in the
Methods in Cell Biology series highlights advances in the field,
with this new volume presenting interesting chapters on timely
topics, including Orthotopic brain tumor models derived from
glioblastoma stem-like cells, RNA sequencing in hematopoietic stem
cells, Generation of inducible pluripotent stem cells from human
dermal fibroblasts, In vitro preparation of dental pulp stem cell
grafts combined with biocompatible scaffolds for tissue
engineering, Gene expression knockdown in chronic myeloid leukemia
stem cells, Identification and isolation of slow-cycling GSCs,
Assessment of CD133, EpCAM, and much more.
The Immunological Synapse - Part B, Volume 178 in the Methods in
Cell Biology series provides state-of-the-art methods for the study
of the immunological synapse. This first volume covers various
aspects on T cell and natural killer (NK) cell synapses, including
imaging polarized granule release using TIRF microscopy, analysis
of actin reorganization and centrosome polarization, redirected
degranulation, live cell-imaging to quantify cytotoxic and
chemotactic dynamics, quantification of interactions between APCs
and T cells, assessment of membrane lipid state at the
immunological synapse, proteomic analysis and imaging of NK-tumor
cell interaction, evaluating natural killer cell effector functions
against breast cancer cells derived from human tumor tissue,
evaluation of chimeric antigen receptor (CAR)-modified cell
immunological synapse quality using the glass-supported planar
lipid bilayer, and monitoring potency of therapeutic CAR T cells.
It also includes one chapter on quantification of lymphocytic
choriomeningitis virus specific T cells and LCMV viral titers, and
one chapter on the murine antibody-dependent cellular phagocytosis
assay.
Molecular Characterization of Autophagic Responses, Part B presents
a collection of methods for the qualitative and quantitative
evaluation of virtually all the morphological, biochemical, and
functional manifestations of autophagy, in vitro, ex vivo and in
vivo, in organisms as distant as yeast and man. Autophagy is an
evolutionarily conserved mechanism for the lysosomal degradation of
superfluous or dangerous cytoplasmic entities, and plays a critical
role in the preservation of cellular and organismal homeostasis.
Monitoring the biochemical processes that accompany autophagy is
fundamental for understanding whether autophagic responses are
efficient or dysfunctional.
International Review of Cell and Molecular Biology (IRCMB), Volume
330 includes comprehensive and detailed reviews on the current
advances in cell and molecular biology. The IRCMB series has a
world-wide readership, maintaining a high standard by publishing
invited articles on important and timely topics authored by
prominent cell and molecular biologists. The articles published in
IRCMB have a high impact and an average cited half-life of nine
years. IRCMB ranks high amongst scientific journals dealing with
cell biology.
Cell senescence is the process whereby cells permanently lose the
possibility to proliferate without undergoing cell death, and
occurs in a plethora of distinct model organisms. In Cell
Senescence: Methods and Protocols, expert researchers in the field
detail the methods that are now commonly used to study cell
senescence, in model organisms encompassing bacteria, fungi, worms,
flies, zebrafish, and mammalian cells. These techniques cover the
study of all the morphological, biochemical and functional
manifestations of senescence at the cellular level and include
protocols for population analyses and high-throughput approaches in
suitable model organisms. Written in the highly successful Methods
in Molecular Biology (TM) series format, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols, and key tips on troubleshooting and avoiding
known pitfalls.
Mitochondria and Bacterial Pathogens, Part B, Volume 375 discusses
different pathogenic mechanisms that converge on the ability of
bacteria to control the mitochondrial compartment of host cells.
Chapters in this new release include Interaction between host cell
mitochondria and Coxiella Burnetii, Control of mitochondrial
functions by Pseudomonas aeruginosa in cystic fibrosis,
Mitochondrial and bacterial ATP synthase: Structural similarities
and divergences to exploit in the battle against M. tuberculosis,
Role of mitochondria in the enteropathogenic Escherichia coli
disease, Mitochondria dynamics and antibiotic resistance, and more.
Cell senescence is the process whereby cells permanently lose the
possibility to proliferate without undergoing cell death, and
occurs in a plethora of distinct model organisms. In Cell
Senescence: Methods and Protocols, expert researchers in the field
detail the methods that are now commonly used to study cell
senescence, in model organisms encompassing bacteria, fungi, worms,
flies, zebrafish, and mammalian cells. These techniques cover the
study of all the morphological, biochemical and functional
manifestations of senescence at the cellular level and include
protocols for population analyses and high-throughput approaches in
suitable model organisms. Written in the highly successful Methods
in Molecular Biology (TM) series format, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols, and key tips on troubleshooting and avoiding
known pitfalls.
Cilia: From Mechanisms to Disease, Part A, Volume 175 in the
Methods in Cell Biology series, offers a range of techniques and
protocols that can be used to study aspects of this interesting
cellular organelle both in vitro and in vivo. In this volume,
different study models are used, such as human cell lines, Mus
musculus, Danio rerio, Paramecium caudatum or Chlamydomonas
reinhardtii. Besides, protocols to study the genesis, morphology,
composition and function of cilia will be addressed. In this book,
the ciliary study will be realized by using different techniques
such as flow cytometry, time-lapse images of fluorescent ciliary
proteins, the use of organoids, the evaluation of the ciliary-GPCR
dynamics or genetic modulation by using CRISPR/Cas9.
Myeloid-Derived Suppressor Cells, Volume 378, includes
comprehensive and detailed reviews on the current advances in
myeloid derived suppressor cells, an immature, heterogenous cell
population from the myeloid lineage that has been extensively
described in the last decades due to its potent immunosuppressive
activity in a variety of pathologies. Reviews maintain a high
standard by publishing invited articles on important and timely
topics authored by prominent researchers. The articles published in
IRCMB have a high impact. IRCMB ranks high amongst scientific
journals dealing with cell biology.
Adoptive Cell Transfer, Volume 371 in the International Review of
Cell and Molecular Biology series highlights advances in the field,
with this new volume presenting interesting chapters written by an
international board of authors who expound on topics such as the
Impact of tumor microenvironment on Adoptive Cell Transfer
activity, Dendritic Cell Transfer, CAR-T Cell dysfunction and
exhaustion, NK Cell-based cancer immunotherapy, Enabling CAR-T
cells for solid tumors: rage against the suppressive tumor
microenvironment, Improving Adoptive T-Cell therapy with cytokines
administration, and What will (and should) be improved in
Immunotherapy with CAR?
In Epigenetic Regulation of Cancer, a series of volumes from the
International Review of Cell and Molecular Biology series, various
experts in epigenetics critically cover multiple facets of
cancer-associated epigenetic alterations, including the impact of
epigenetic deregulation in all steps of oncogenesis as well as
promising strategies to therapeutically target cancer-associated
epigenetic deregulation. This collection aims at expanding our
knowledge on this exciting field of investigation and providing
fresh insights as a basis for further investigations that will
hopefully translate into an improved clinical management of
patients with cancer.
The Immunological Synapse, Part A, Volume 173 in the Methods in
Cell Biology series provides state-of-the-art methods for the study
of the immunological synapse. Sections cover Imaging polarized
granule release at the cytotoxic T cell immunological synapse using
TIRF microscopy: control by polarity regulators, Analysis of
centrosomal area actin reorganization and centrosome polarization
upon lymphocyte activation at the immunological synapse, P815-based
redirected degranulation assay to study human NK cell effector
functions, Cytotoxic and Chemotactic Dynamics of Natural Killer
Cells Quantified by Live-cell Imaging, Quantification of
interaction frequency between antigen-presenting cells and T cells
by conjugation assay, and more. Other chapters focus on the Study
of the Effects of NK-Tumor Cell Interaction by Proteomic Analysis
and Imaging, Quantification of lymphocytic choriomeningitis virus
specific T cells and LCMV viral titers, Quantification of
lymphocytic choriomeningitis virus specific T cells and LCMV viral
titers, An in vitro model to monitor natural killer cell effector
functions against primary breast cancer, and Standardized Protocol
for the Evaluation of Chimeric Antigen Receptor (CAR)-modified Cell
Immunological Synapse Quality using the Glass-supported Planar L.
Non-canonical Autophagy: Mechanisms and Pathophysiological
Implications outlines the differences between 'canonical' and
'non-canonical' forms of autophagy, highlighting the discoveries
concerning the molecular mechanisms underlying these unconventional
forms of autophagy and the advancements in pathophysiological
features of 'non-canonical' autophagy. The book discusses all forms
of 'non-canonical' autophagy and the complexity of
autophagy-dependent cell death. Readers will gain a better
understanding of mechanisms underlying 'non-canonical' autophagy so
that they can interpret the biological effects of autophagy
correctly and identify reliable, novel and effective treatment
strategies.
Ionizing Radiation and the Immune Response, Volume 376, Part A
reviews the latest updates on the immune response induced by
ionizing radiations. Sections discuss the role of specific immune
cells (macrophage, lymphocyte, NK cells...) and describe the effect
of modern radiotherapy techniques (TRT, minibeams, flash-RT, proton
therapy, heavy ions...) on immune response. Sample chapters cover
NK functions in radio-induced immune response, TRT and immune
response, Radio-induced immune response and lipid metabolism,
Effect of protons and heavy ions on immune response, Effect of
flashtherapy and mini beam on immune response, Radio-induced
lymphopenia, CT to potentiate radio-induced immune response, and
much. Other sections focus on the Effect of low dose radiation on
radio-induced immune response, Role of Dendritic cells in
radiation-induced immune response, Relationship between the tumor
microenvironment and the efficacy of the radiotherapy/immunotherapy
combination+A23, Biomarkers of radiation induced response to
optimize radio-immunotherapy combination.
Cilia: From Mechanisms to Disease Part B, Volume 176 of Methods in
Cell Biology series, highlights new advances in the field, with
this new volume presenting interesting chapters. Each chapter is
written by an international board of authors.
International Review of Cell and Molecular Biology, Volume 337
reviews and details current advances in cell and molecular biology.
The IRCMB series has a worldwide readership, maintaining a high
standard by publishing invited articles on important and timely
topics that are authored by prominent cell and molecular
biologists. Sections in this new release include the karyosphere
(karyosome) and its peculiar structure of the oocyte nucleus,
organoids as models of disease, lipid droplets as organelles, the
dark side of apoptosis, interconnections between autophagy and
secretion, and the regulation and function of intracellular
pressure in cell biology.
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