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Immunology is a nodal subject that links many areas of biology. It
permeates the biosciences, and also plays crucial roles in
diagnosis and therapy in areas of clinical medicine ranging from
the control of infectious and autoimmune diseases to tumour
therapy. Monoclonal antibodies and small molecule modulators of
immunity are major factors in the pharmaceutical industry and now
constitute a multi billion dollar business. Students in these
diverse areas are frequently daunted by the complexity of
immunology and the astonishing array of unusual mechanisms that go
to make it up. Starting from Dobzhansky's famous slogan, "Nothing
in biology makes sense except in the light of evolution", this book
will serve to illuminate how evolutionary forces shaped immunity
and thus provide an explanation for how many of its counter
intuitive oddities arose. By doing so it will provide a conceptual
framework on which students may organise the rapidly growing flood
of immunological knowledge.
This volume provides in-depth reviews of model systems that
exemplify the arms race in host-pathogen interactions. Somatic
adaptations are responsible for the individualization of biological
responses to the environment, and the continual struggle between
host immune systems and invading pathogens has given rise to
corresponding processes that produce molecular variation. Whether
in mollusks or human beings, various host somatic mechanisms have
evolved independently, providing responses to counter
rapidly-changing pathogens. The pathways they utilize can include
non-heritable changes involving RNA and post-translational
modifications, or changes that produce somatic DNA recombination
and mutation. For infectious organisms such as protozoans and
flatworms, antigenic variation is central to their survival
strategy. Evolving the ability to evade the host immune system not
only increases their chances of survival but is also necessary for
successful re-infection within the host population.
This volume provides in-depth reviews of model systems that
exemplify the arms race in host-pathogen interactions. Somatic
adaptations are responsible for the individualization of biological
responses to the environment, and the continual struggle between
host immune systems and invading pathogens has given rise to
corresponding processes that produce molecular variation. Whether
in mollusks or human beings, various host somatic mechanisms have
evolved independently, providing responses to counter
rapidly-changing pathogens. The pathways they utilize can include
non-heritable changes involving RNA and post-translational
modifications, or changes that produce somatic DNA recombination
and mutation. For infectious organisms such as protozoans and
flatworms, antigenic variation is central to their survival
strategy. Evolving the ability to evade the host immune system not
only increases their chances of survival but is also necessary for
successful re-infection within the host population.
Immunology is a nodal subject that links many areas of biology. It
permeates the biosciences, and also plays crucial roles in
diagnosis and therapy in areas of clinical medicine ranging from
the control of infectious and autoimmune diseases to tumour
therapy. Monoclonal antibodies and small molecule modulators of
immunity are major factors in the pharmaceutical industry and now
constitute a multi billion dollar business. Students in these
diverse areas are frequently daunted by the complexity of
immunology and the astonishing array of unusual mechanisms that go
to make it up. Starting from Dobzhansky's famous slogan, "Nothing
in biology makes sense except in the light of evolution", this book
will serve to illuminate how evolutionary forces shaped immunity
and thus provide an explanation for how many of its counter
intuitive oddities arose. By doing so it will provide a conceptual
framework on which students may organise the rapidly growing flood
of immunological knowledge.
This is a reproduction of a book published before 1923. This book
may have occasional imperfections such as missing or blurred pages,
poor pictures, errant marks, etc. that were either part of the
original artifact, or were introduced by the scanning process. We
believe this work is culturally important, and despite the
imperfections, have elected to bring it back into print as part of
our continuing commitment to the preservation of printed works
worldwide. We appreciate your understanding of the imperfections in
the preservation process, and hope you enjoy this valuable book.
++++ The below data was compiled from various identification fields
in the bibliographic record of this title. This data is provided as
an additional tool in helping to ensure edition identification:
++++ Cours De Dessin Professe a L'ecole De La Martiniere 2 Louis
Dupasquier Perrin, 1852
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