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Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations (Hardcover, 1st ed. 2015)
Loot Price: R5,744
Discovery Miles 57 440
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Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations (Hardcover, 1st ed. 2015)
Series: Results and Problems in Cell Differentiation, 57
Expected to ship within 10 - 15 working days
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This volume provides in-depth reviews of model systems that
exemplify the arms race in host-pathogen interactions. Somatic
adaptations are responsible for the individualization of biological
responses to the environment, and the continual struggle between
host immune systems and invading pathogens has given rise to
corresponding processes that produce molecular variation. Whether
in mollusks or human beings, various host somatic mechanisms have
evolved independently, providing responses to counter
rapidly-changing pathogens. The pathways they utilize can include
non-heritable changes involving RNA and post-translational
modifications, or changes that produce somatic DNA recombination
and mutation. For infectious organisms such as protozoans and
flatworms, antigenic variation is central to their survival
strategy. Evolving the ability to evade the host immune system not
only increases their chances of survival but is also necessary for
successful re-infection within the host population.
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