This book is one result from the 1996 Millimeter-wave Summer School held at the Instituto Nacional de Astrofisica, Optica y Electronica (INAOE), Tonantz- intla, Puebla, Mexico. In collaboration with the University of Massachusetts, INAOE has embarked upon the ambitious project of building the world's largest filled aperture millimeter-wave telescope - the Large Millimeter-wave Tele- scope (LMT), or Gran Telescopio Milimetrico (GTM). The LMT is currently the largest scientific project in Mexico. The summer school had a dual purpose; first, to introduce the Mexican as- tronomical and physics communities to millimeter wavelength astronomy, and second, to provide a forum for a review of several important aspects of the state of the art in observations, theory, interpretation, and technology relevant to this branch of astronomy. The summer school had 18 invited speakers and 44 par- ticipants. The scientific organizing committee (SOC) consisted of Luis Carrasco (UNAM/INAOE, Mexico), Paul Goldsmith (NAIC, Cornell Univ., USA), and Andy Harris (Univ. of Maryland, USA). Members of the local organizing com- mittee (LOC) were Alberto Carramiiiana (INAOE), Emmanuel Mendez Palma (INAOE), Mari Paz Miralles (Harvard-Smithsonian Center for Astrophysics, USA), and William Wall (INAOE).

Structure of a Human Rhinovirus Complexed with its Receptor Molecule; N.H. Olson, et al. Cascade Regulation of Vaccinia Virus Gene Expression; B. Moss. Transcriptional Activation by the Adenovirus E1A Proteins; B.A. Lewis, T. Shenk. Mechanisms Regulating Nucleocapsid Formation of the Hepatitis B Viruses; R. Bartenschlager, H. Schaller. Transcriptional Activation by the Hepatitis B Virus X Protein; R. Lucito, R.J. Schneider. Transcription Factors of the ETS Family; K. Macleod, et al. Structure and Function of the Vesicular Stomatitis Virus RNA-Dependent RNA Polymerase; S. Barik, et al. RNA Synthesis and mRNA Editing in Paramyxovirus Infections; J. Curran, et al. Translational Regulation by Reovirus Structural Proteins; A.J. Shatkin, et al. The Regulation of Coronavirus Gene Expression; S.G. Siddell. Aspects of the Molecular Biology of Poliovirus Replication; J. Harber, E. Wimmer. 9 additional articles. Index.

The present book is intended to give an account of the state of the art on how animal viruses induce cytotoxic effects in cells.

This book is one result from the 1996 Millimeter-wave Summer School held at the Instituto Nacional de Astrofisica, Optica y Electronica (INAOE), Tonantz- intla, Puebla, Mexico. In collaboration with the University of Massachusetts, INAOE has embarked upon the ambitious project of building the world's largest filled aperture millimeter-wave telescope - the Large Millimeter-wave Tele- scope (LMT), or Gran Telescopio Milimetrico (GTM). The LMT is currently the largest scientific project in Mexico. The summer school had a dual purpose; first, to introduce the Mexican as- tronomical and physics communities to millimeter wavelength astronomy, and second, to provide a forum for a review of several important aspects of the state of the art in observations, theory, interpretation, and technology relevant to this branch of astronomy. The summer school had 18 invited speakers and 44 par- ticipants. The scientific organizing committee (SOC) consisted of Luis Carrasco (UNAM/INAOE, Mexico), Paul Goldsmith (NAIC, Cornell Univ., USA), and Andy Harris (Univ. of Maryland, USA). Members of the local organizing com- mittee (LOC) were Alberto Carramiiiana (INAOE), Emmanuel Mendez Palma (INAOE), Mari Paz Miralles (Harvard-Smithsonian Center for Astrophysics, USA), and William Wall (INAOE).

Viruses, being obligatory parasites of their host cells, rely on a vast supply of cellular components for their replication, regardless of whether infection leads to cell death or to the state of persistence. Animal viruses are providing scientists with relatively simple models to study the molecular biology of genome replication and gene expression. Whereas viruses use, in general, pathways of macromolecular biosynthesis common to the host cell, they have a cunning ability to adopt unusual mechanisms of gene expression and gene replication, provided these special pathways offer an advantage in competition for cellular resources. Any study of viral gene expression and replication is likely to lead also to new insights in cellular metabolism. The discoveries of cis-acting regulatory elements in transcription, the phenomenon of splicing of pre mRNA, and cap-dependent and cap-independent initiation of translation may be cited as examples. In addition, animal virus genomes contain elements and encode proteins that are very useful for the design of vectors for gene cloning and expression in mammalian cells. Apart from the basic interest in their biology, viruses have gained notoriety, of course, because they are pathogens. Human animal viruses may cause diseases ranging from the deadly (AIDS) to the benign (common cold). All studies on animal viruses potentially lead to the development of tools for their control, be it through prevention by immunization or treatment with antiviral drugs. Finally, viruses have yielded invaluable reagents in molecular biology as, for example, the vaccinia virus vector for the expression of foreign genes.

Set in the stark beauty of the Andalusian mountains El Hacho tells the story of Curro, an olive farmer determined to honour his family tradition in the face of drought, deluge and the lucrative temptations of a rapidly modernising Spain. Wonderfully crafted, El Hacho is a poignant and compelling story of struggle and hope.

A young girl, anonymous and ignored, sits through a cold, hard west-country winter, scrounging for change and a warm place to sleep. Ghosts of Spring explores one girl's desire to transcend the limits of her environment and forge a new life against all the odds.