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Based on a unique comparative analysis of the education and work experiences of those who lived through the political and labour market changes of the transition to post-communism, the authors argue that, far from catching up with the rest of Germany, the social polarisations and erosion of the traditional 'dual system' of vocational education and training in Eastern Germany may portend the future for the West. The issues raised have considerable resonances with the problems and contradictions which have beset British education and training and labour market policy over the last decade.
Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder - from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors, and treatment.
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