Tackling translational medicine with a focus on the drug discovery development-interface, this book integrates approaches and tactics from multiple disciplines, rather than just the pharmaceutical aspect of the field. The authors of each chapter address the paradox between the molecular understanding of diseases, drug discovery, and drug development. Laying out the detailed trends from various fields, different chapters are dedicated to target engagement, toxicological safety assessments, and the compelling relationship of optimizing early clinical studies with design strategies. The book also highlights the importance of balancing the three pillars: sufficient efficacy, acceptable safety and appropriate pharmacokinetics, all of which are crucial to successful efforts in discovery and development. With discussions regarding the combined approaches of molecular research, personalized medicine, pre-clinical and clinical development, as well as targeted therapies-this compendium is a flexible fit, perfect for professionals in the pharmaceutical industry and related academic fields.

'The text is easy to read because the matter is clearly explained. Symmetries are a central component of physical laws, and the PT-symmetry proves to be very interesting and fruitful. The discussion of the matter is up-to-date and self-contained. The book is recommended to students of higher courses, PhD and researchers. It is also a basic read to those who wish to have an insight into this field.'Contemporary PhysicsOriginated by the author in 1998, the field of PT (parity-time) symmetry has become an extremely active and exciting area of research. PT-symmetric quantum and classical systems have theoretical, experimental, and commercial applications, and have been the subject of many journal articles, PhD theses, conferences, and symposia. Carl Bender's work has influenced major advances in physics and generations of students.This book is an accessible entry point to PT symmetry, ideal for students and scientists looking to begin their own research projects in this field.

'The text is easy to read because the matter is clearly explained. Symmetries are a central component of physical laws, and the PT-symmetry proves to be very interesting and fruitful. The discussion of the matter is up-to-date and self-contained. The book is recommended to students of higher courses, PhD and researchers. It is also a basic read to those who wish to have an insight into this field.'Contemporary PhysicsOriginated by the author in 1998, the field of PT (parity-time) symmetry has become an extremely active and exciting area of research. PT-symmetric quantum and classical systems have theoretical, experimental, and commercial applications, and have been the subject of many journal articles, PhD theses, conferences, and symposia. Carl Bender's work has influenced major advances in physics and generations of students.This book is an accessible entry point to PT symmetry, ideal for students and scientists looking to begin their own research projects in this field.

Against the backdrop of two recent socio-political developments-the shift from the Obama to the Trump administration and the surge in nationalist and populist sentiment that ushered in the current administration-Contested Commemoration in U.S. History presents eleven essays focused on practices of remembering contested events in America's national history. This edited volume contains fresh interpretations of public history and collective memory that explore the evolving relationship between the U.S. and its past. The individual chapters investigate efforts to memorialize events or interrogate instances of historical sanitization at the expense of less partial representations that would include other perspectives. The primary source material and geography covered is extensive; contributors use historic sites and monuments, photographs, memoirs, textbooks, periodicals, music, and film to discuss the periods from colonial America, through the Revolutionary and Civil Wars up until the Vietnam War, Civil Rights movement, and Cold War, to explore how the commemoration of those eras resonates in the twenty-first century. Through a range of commemoration media and primary sources, the authors illuminate themes and arguments that are indispensable to students, scholars, and practitioners interested in Public History and American Studies more broadly.

Tackling translational medicine with a focus on the drug discovery development-interface, this book integrates approaches and tactics from multiple disciplines, rather than just the pharmaceutical aspect of the field. The authors of each chapter address the paradox between the molecular understanding of diseases, drug discovery, and drug development. Laying out the detailed trends from various fields, different chapters are dedicated to target engagement, toxicological safety assessments, and the compelling relationship of optimizing early clinical studies with design strategies. The book also highlights the importance of balancing the three pillars: sufficient efficacy, acceptable safety and appropriate pharmacokinetics, all of which are crucial to successful efforts in discovery and development. With discussions regarding the combined approaches of molecular research, personalized medicine, pre-clinical and clinical development, as well as targeted therapies-this compendium is a flexible fit, perfect for professionals in the pharmaceutical industry and related academic fields.

Many NLP tasks have at their core a subtask of extracting the dependencies-who did what to whom-from natural language sentences. This task can be understood as the inverse of the problem solved in different ways by diverse human languages, namely, how to indicate the relationship between different parts of a sentence. Understanding how languages solve the problem can be extremely useful in both feature design and error analysis in the application of machine learning to NLP. Likewise, understanding cross-linguistic variation can be important for the design of MT systems and other multilingual applications. The purpose of this book is to present in a succinct and accessible fashion information about the morphological and syntactic structure of human languages that can be useful in creating more linguistically sophisticated, more language-independent, and thus more successful NLP systems. Table of Contents: Acknowledgments / Introduction/motivation / Morphology: Introduction / Morphophonology / Morphosyntax / Syntax: Introduction / Parts of speech / Heads, arguments, and adjuncts / Argument types and grammatical functions / Mismatches between syntactic position and semantic roles / Resources / Bibliography / Author's Biography / General Index / Index of Languages

Against the backdrop of two recent socio-political developments-the shift from the Obama to the Trump administration and the surge in nationalist and populist sentiment that ushered in the current administration-Contested Commemoration in U.S. History presents eleven essays focused on practices of remembering contested events in America's national history. This edited volume contains fresh interpretations of public history and collective memory that explore the evolving relationship between the U.S. and its past. The individual chapters investigate efforts to memorialize events or interrogate instances of historical sanitization at the expense of less partial representations that would include other perspectives. The primary source material and geography covered is extensive; contributors use historic sites and monuments, photographs, memoirs, textbooks, periodicals, music, and film to discuss the periods from colonial America, through the Revolutionary and Civil Wars up until the Vietnam War, Civil Rights movement, and Cold War, to explore how the commemoration of those eras resonates in the twenty-first century. Through a range of commemoration media and primary sources, the authors illuminate themes and arguments that are indispensable to students, scholars, and practitioners interested in Public History and American Studies more broadly.

This book gives a clear, practical and self-contained presentation of the methods of asymptotics and perturbation theory and explains how to use these methods to obtain approximate analytical solutions to differential and difference equations. These methods allow one to analyze physics and engineering problems that may not be solvable in closed form and for which brute-force numerical methods may not converge to useful solutions. The objective of this book is to teaching the insights and problem-solving skills that are most useful in solving mathematical problems arising in the course of modern research. Intended for graduate students and advanced undergraduates, the book assumes only a limited familiarity with differential equations and complex variables. The presentation begins with a review of differential and difference equations; develops local asymptotic methods for differential and difference equations; explains perturbation and summation theory; and concludes with a an exposition of global asymptotic methods, including boundary-layer theory, WKB theory, and multiple-scale analysis. Emphasizing applications, the discussion stresses care rather than rigor and relies on many well-chosen examples to teach the reader how an applied mathematician tackles problems. There are 190 computer-generated plots and tables comparing approximate and exact solutions; over 600 problems, of varying levels of difficulty; and an appendix summarizing the properties of special functions.

Meaning is a fundamental concept in Natural Language Processing (NLP), in the tasks of both Natural Language Understanding (NLU) and Natural Language Generation (NLG). This is because the aims of these fields are to build systems that understand what people mean when they speak or write, and that can produce linguistic strings that successfully express to people the intended content. In order for NLP to scale beyond partial, task-specific solutions, researchers in these fields must be informed by what is known about how humans use language to express and understand communicative intents. The purpose of this book is to present a selection of useful information about semantics and pragmatics, as understood in linguistics, in a way that's accessible to and useful for NLP practitioners with minimal (or even no) prior training in linguistics.

A clear, practical and self-contained presentation of the methods of asymptotics and perturbation theory for obtaining approximate analytical solutions to differential and difference equations. Aimed at teaching the most useful insights in approaching new problems, the text avoids special methods and tricks that only work for particular problems. Intended for graduates and advanced undergraduates, it assumes only a limited familiarity with differential equations and complex variables. The presentation begins with a review of differential and difference equations, then develops local asymptotic methods for such equations, and explains perturbation and summation theory before concluding with an exposition of global asymptotic methods. Emphasizing applications, the discussion stresses care rather than rigor and relies on many well-chosen examples to teach readers how an applied mathematician tackles problems. There are 190 computer-generated plots and tables comparing approximate and exact solutions, over 600 problems of varying levels of difficulty, and an appendix summarizing the properties of special functions.

Re-Volt Komics is a monthly anthology created by mangaka and comic artists from around the world who all celebrate the spirit of revolution. By coming together from many different cultures and different nationalities the creators of this anthology hope to show western comic book companies and eastern manga companies our 'Komics.' N00b of Clandestein - In a time not so far away from today, the internet is a shadow of its former self, corporations and nations are indistinguishable, and the last place for human solitude lies within the unregulated pocket of virtual space that resides within the human mind, The Etha. A game that is passed off as a medical treatment is in truth a world onto itself, untouched by the outside world and indistinguishable from reality and dream. Enter Puck and Goose, two boys who fight in two worlds. Way of Wushu - Chanda's master, the man who saved her from a life as a street urchin, is imprisoned by the Celestial Empire for crimes committed in his youth. She sets out to free him by winning the Celestial Tournament; the winner of which can meet the Emperor and make one request of him. But to do so she needs to be recognized and sponsored, which means forging a name for herself. Graphene: Innocent as Sin - In a country run by money of individuals and conglomerates rather than the elected puppets its people put into place, a group of children try to thrive. They reminisce at how the system created to nurture, protect, and love them simply forgot them. Rising against the rules in place was the only way for them to survive in the midst of cruelty and a broken world full of death. Red Shift - Year 2093, Earth is a glorified garbage dump where people unlucky enough to still be born there live and die maintaining the status quo. Tuck Airedale refuses to be just another cog in the down-trodden machine and takes a gamble. Can a 21st century fighter jet converted for space flight really be his ticket off-world? It can be if he pulls off placing high enough in the star racing Terran Qualifiers to make it to the Gold Prix. Being a rookie is is already a risk, but can he really win a space race in an airplane?

Re-Volt Komiks is a Monthly Publication for aspiring artists from around the world who all wish to submit one shots and serial komiks of any style in the spirit of revolution.
Serial komiks in this issue: Noob 0f Clandestine, Graphene: Innocent as Sin, and Jinrui Origins
One shot Komiks in this issue: Redshift (part 2), and Pneumatica

The United States Army has a long history of advising foreign security forces with its general purpose force, despite a perception that its special force is the primary force with which it undertakes advisory efforts. Ad hoc selection and assignment and inadequate training of Army general purpose force advisors in Iraq and Afghanistan led to a rediscovery of lessons learned. Despite the Army's 110 years of advisory experience with its general purpose force, problems encountered in the Korea and Vietnam advisory efforts regarding advisor training, advisory group organization, and advisor assignments point to the Army's need to institutionalize advisory capability and capacity within its general purpose force. The relevance of general purpose force advising in Korea and Vietnam, however, place a specific light on contemporary advising efforts and demonstrate the Army's need to adapt the manner in which it prepares the general purpose force personnel to advise foreign security forces. With the elevation of the concept of 'building partner capacity' to the level of national security doctrine in 2010, the Army finds itself behind its sister services with respect to institutionalizing advisory capacity and capability within its general purpose force. The resistance by Army senior leaders to divert what they perceive as limited resources within the conventional force conflicts with its anticipating future operations increasingly involving general purpose force personnel advising foreign security forces. This monograph recommends the Army expand its Foreign Area Officer program to include a secondary track to train and manage general purpose force advisors and establish a formal advisory command to create needed capacity and capability within the general purpose force.

Poet Jack Bender brings an amazing diversity of life experiences to his poetry. He's been a U.S. Army officer, a computer programmer and a musician who also taught music in schools and in prisons. He has written widely about teaching, and was selected for the pilot program of The Courage to Teach. Currently, he is a mediator working to resolve conflicts referred by the court system. His poems express the growing depth of his reflections on human relationships and the teachings of the natural world that surrounds us. Deepest of all is his understanding of experiences that go beyond words, touching the mystery of life's meaning and the presence of God. His poems are echoed in their depth by the art of Cindy Bender, present here not to 'illustrate' the poetry, but to add the speech of a painter to the voice of the poet. This is a 'keeper' book-to enjoy, share with friends...and, most of all, to read, re-read and then read again.

"Lest They Forget Freedom's Price," is the fascinating story of B-17 bomber pilot Edward M. Bender (USAAFR retired Lt. Col.), who describes his flight training, bomber missions, capture, and time as a POW in Europe during World War II. When a fire forces the crew of his Flying Fortress down in enemy-occupied France, Lt. Bender is captured by a unit of teenage NAZI recruits from Adolph Hitler's youth corps. He describes his year as a prisoner of the Third Reich at camps in Sagan, Nurnberg, and Moosburg, and the bitterly cold forced march of Winter 1945, when the Germans and POWs evacuated the Stalag Luft III prison camp in anticipation of the advancing Russian army. Finally, Lt. Bender is liberated by Gen. George Patton's army and returns home to adapt to the challenges of life in post-war America. Filled with humor and pathos, this narrative provides a portrait of life in war-time Europe and America, and the challenges faced by an American airman and POW.

Throughout most of my adult life, and especially since the loss of my father eight years ago, I have strived to make a positive difference in the lives of others. By example, and through precious memory, he has taught me the lesson that one person truly can make a difference; therefore, I have modeled myself around his quality of character. I live a modest life, much like he did, and dedicate my energy to the simple yet powerful idea that we should all live in a way that we would be proud to be remembered by.

In memory of my father (an English teacher of thirty years), I have written a collection of inspirational poems in attempt to awaken the goodness in people, and motivate them to seek out the goodness in others. As a Registered Nurse, I understand the subservient strength within many that proves to prevail with the subtle inspiration that my poems venture to offer.