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Trials in the treatment of the leukemias are sometimes based on a
hypothesis, as in the case of exchange transfusion [33] or the use
of antimetabolites [86]. Or they are conducted empirically as the
results of chance observations, as in the case of the use of the
nitrogen mustards, urethane, and the Vinca alkaloids. Or they lie
between the two, aiming at making use of well established
biological facts: examples are the use of ACTH, cortisone and, more
recently, the antibiotics. What is true for bacteria may also
perhaps be true, if not for elephants, at least for the malignant
cells of mammals. It was this idea that lay behind the first
attempts at treating cancer and leukemia with antibiotics. The
results obtained by the use of certain substances extracted from
micro-organisms (actinomycin, azaserine, mito mycin,
rufocromomycin), although encouraging at times, were inconsistent.
The action of rubidomycin appears to cover a wider spectrum and to
be more consistent and more effective. As in the case of Homer and
Christopher Columbus, the honor of having given birth to
rubidomycin is claimed by more than one country and town. In fact,
the same product was discovered in the same year, though quite
independently, by a group of French workers [184] who described it
under the name of rubidomycin, and by a group of Italian workers
[87] who studied it under the name of daunomycin.
Any professional concerned with immunology will be interested in
this book dedicated to the memory of Milan Hasek, former director
of the Prague Institute of Experimental Biology and Genetics. Prof.
Hasek was a congenial scientist and most amiable person - a
personal friend of almost all leading immunologists around the
world. He was displaced from his post of director in 1970, yet had
a lasting impact upon his students and the group known as the
Prague School of Immunogenetics. The topics covered in the
contributions range from tolerance, immune network, and
immunogenetics to the immunology of bacterial and viral infections.
They are written by 27 of Prof. Hasek's former co-workers who
emigrated to western countries around or after 1968 and became
well-known and distinguished scientists in the field. The papers
include their personal reflections of the Prague Institute, their
impressions upon arriving abroad and their interesting experimental
work since then. The book also provides a complete bibliography of
their publications after leaving Czechoslovakia.
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