This book records the proceedings of a joint U.S.-Japan symposium on the chem istry, biochemistry, and biology of bleomycin, an antitumor antibiotic shown to be effective therapeutically against, eg, squamous cell carcinomas, Hodgkin's lymphoma, and testicular tumors. Several important and previously unreported observations were presented and the status of experimental work in the United States and Japan was reviewed; a summary and interpretation of the scientific presentations at the meeting has been prepared by the editor and is included as the first contribution in this volume. In addition to the symposium contributions, an experimental section has been included at the end of the book dealing with practical methods for the fractiona tion, modification, and assay of bleomycin. It is hoped that this section will facilitate progress in this area of scientific endeavor. The symposium from which this book is derived was organized by Drs. Umezawa, Takita, and Hecht and supported financially by the National Science Foundation, the National Cancer Institute, and the Japan Society for the Promotion of Science. S. M. Hecht v Contents Status Reports Summary of the Bleomycin Symposium. S. M. HECHT .............. 1 Advances in Bleomycin Studies. H. UMEZAWA ..................., 24 Review of the Structural Studies on Bleomycin. T. TAKITA . . . . . . . .. . . 37 . Synthetic and Biosynthetic Studies Studies on the Total Synthesis of Bleomycin. S. M. HECHT, D. 1. BURLETT, Y. MUSHIKA, Y. KURODA, and M. D. LEVIN .......... 48 A Synthetic Approach to the Pyrimidine Moiety of Bleomycin."

Verkehrsl rm ist l stig und leistungsmindernd; er birgt dar ber hinaus auch gesundheitliche Risiken. Die kontinuierliche Zunahme des Verkehrs entfacht daher gesellschaftliche Konflikte um Mobilit t trotz bestehender Regulierungen.

Die Europ ische Akademie hat im Rahmen eines interdisziplin ren Projekts die rationale Beurteilung der L rmrisiken und M glichkeiten ihrer Reduktion vorgenommen, ohne den gesellschaftlichen Nutzen von Mobilit t aus dem Auge zu verlieren. Die Autoren bieten Vorschl ge f r weitergehende Regulierungen und pl dieren u.a. daf r, Ruhe als sch tzenswertes Rechtsgut zu verankern.

This reader’s edition of The Greek New Testament, Produced at Tyndale House, Cambridge allows readers to translate and annotate as they study the Greek text.