This book reports on the current state of knowledge about adreno ceptors and their involvement in the pathogenesis and treatment of high blood pressure. This is a relatively recent and extremely excit ing addition to the field of hypertension research. The development of new analytical procedures, such as radio ligand-binding methods, has made it possible to identify and quantify the adrenoceptors in different tissues and in circulating blood cells. As a consequence, much new and valuable information has been obtained. An under standing of the role of the fJ-adrenoceptor-adenylatecyclase-cAMP system in hypertension is one such product of this new approach. Both review articles and new experimental and clinical data are included in this volume. New aspects of the distribution, identifica tion and regulation, and the chronopharmacology of adrenoceptors, as well as beta blockade, will be highlighted. The clinical contributions concern the normal regulation of the fJ adrenoceptor-adenylatecyclase-cAMP system, and how it is altered in hypertensives as a possible mechanism in the pathogenesis and maintenance of essential hypertension. With this knowledge it is be coming easier to explain the molecular and cellular action behind the familiar role of the sympathico-adrenergic system in the devel opment of hypertension and the mechanism of beta blockade. The vast majority of the data available in this field is confined to periph eral mechanisms, owing to the limited possibilities for investigating the central nervous system under clinical conditions."

This collection analyzes philosophical, psycho-analytic and aesthetic contexts of the discourse of melancholia in British and postcolonial literature and culture and seeks to trace the multi-faceted phenomenon of melancholia from the early modern period to the present. Texts discussed range from Shakespeare and Milton to Coetzee and Barker.

This collection analyzes philosophical, psycho-analytic and aesthetic contexts of the discourse of melancholia in British and postcolonial literature and culture and seeks to trace the multi-faceted phenomenon of melancholia from the early modern period to the present. Texts discussed range from Shakespeare and Milton to Coetzee and Barker.

"Diese neue Reihe widmet sich der praxisnahen Fortbildung von" "Allgemeinarzten und Internisten auf dem gesamten Terrain der" "Herz-Kreislauf-Erkrankungen. Ein Teil der Bande konzentriert" "sich auf kompakte Krankheitslehre " "(Krankheitsbilder/Differentialtherapie), der andere Teil " "beschaftigt sich mit dem prophylaktischen und " "therapeutischen Potential moderner " "Therapieprinzipien."Nichtmedikamentose Strategien haben einen hohen Stellenwert in der Behandlung kardiovaskularer Erkrankungen - v.a. deren Risikofaktoren. Die zumeist uber ungesunde Lebensweise und Ernahrungsverhalten vielschichtig miteinander gekoppelten Risikofaktoren konnen uber diese Behandlungsform positiv beeinflusst werden. Basierend auf den neuesten wissenschaftlichen Erkenntnissen wird in diesem Buch die nichtmedikamentose Behandlung des Diabetes mellitus, der Hyperlipoproteinamien, der Adipositas, der Hypertonie und des Rauchens beschrieben. Neben dem wissenschaftlichen Datenmaterial (660 Literaturzitate) gibt das Buch dem Leser konkrete Hinweise und Empfehlungen fur die Umsetzung der Erkenntnisse in die tagliche Praxis an die Hand. Diese sind, jedem Kapitel vorgeschaltet, auf besonders gekennzeichneten Seiten ("Uberblick fur die Praxis") schnell auffindbar."