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New Aspects in Hypertension Adrenoceptors - Symposium, November 1985, Munich (Paperback, Softcover reprint of the original 1st ed. 1986)
Loot Price: R2,785
Discovery Miles 27 850
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New Aspects in Hypertension Adrenoceptors - Symposium, November 1985, Munich (Paperback, Softcover reprint of the original 1st ed. 1986)
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This book reports on the current state of knowledge about adreno
ceptors and their involvement in the pathogenesis and treatment of
high blood pressure. This is a relatively recent and extremely
excit ing addition to the field of hypertension research. The
development of new analytical procedures, such as radio
ligand-binding methods, has made it possible to identify and
quantify the adrenoceptors in different tissues and in circulating
blood cells. As a consequence, much new and valuable information
has been obtained. An under standing of the role of the
fJ-adrenoceptor-adenylatecyclase-cAMP system in hypertension is one
such product of this new approach. Both review articles and new
experimental and clinical data are included in this volume. New
aspects of the distribution, identifica tion and regulation, and
the chronopharmacology of adrenoceptors, as well as beta blockade,
will be highlighted. The clinical contributions concern the normal
regulation of the fJ adrenoceptor-adenylatecyclase-cAMP system, and
how it is altered in hypertensives as a possible mechanism in the
pathogenesis and maintenance of essential hypertension. With this
knowledge it is be coming easier to explain the molecular and
cellular action behind the familiar role of the
sympathico-adrenergic system in the devel opment of hypertension
and the mechanism of beta blockade. The vast majority of the data
available in this field is confined to periph eral mechanisms,
owing to the limited possibilities for investigating the central
nervous system under clinical conditions."
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