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Since its first publication in 1996, Marie Muller's Nursing
Dynamics has become firmly established as an essential resource for
nursing courses. This fifth edition addresses the latest challenges
nursing professionals face and expands the focus to include all
managers in healthcare service management. Nursing and midwifery
educators who relied on earlier editions of this work will find
that their discipline is still the core of this book, with the
management aspects broadened to include general healthcare
dynamics. Subjects range from professional regulation to
governance, decision making, financial management, quality
management and continuing professional development. New features
include the introduction of digital elements including online
student–lecturer support material and a digital portfolio of
evidence to enrich the content. The practical application of
principles has been formalised with the inclusion of case studies
and assignments at the end of each chapter. These exercises follow
a Head-Heart-Hands model, covering the knowledge behind the
principle, the ethical and "duty of care" considerations, and the
hands-on application.
This updated and improved edition of Healthcare Service Management
presents the latest best practice guidelines related to the
management of a healthcare organisation. The text examines those
aspects of management that are specific to healthcare institutions,
including health-related legislation, common law, and ethics. In
addition to fulfilling the needs of the nursing student and
lecturer, it will serve as a reference on healthcare service
management for any practising manager.
Provides a broad overview of Industry 4.0 in SMEs, covering twelve
countries in various national, historical, and geographical
settings Describes barriers, drivers and opportunities for Industry
4.0 and related digitalization programs Consolidates the
experiences of Industry 4.0 implementation in SMEs across different
parts of the globe Compares firms of similar size and
digitalization levels across the available data of various SMEs
worldwide Includes descriptions of what is happening in SMEs in
order to increase industrial competitiveness
An interdisciplinary environmental humanities volume that explores
human-environment relationships on our permanently polluted planet.
While toxicity and pollution are ever present in modern daily life,
politicians, juridical systems, media outlets, scholars, and the
public alike show great difficulty in detecting, defining,
monitoring, or generally coming to terms with them. This volume's
contributors argue that the source of this difficulty lies in the
struggle to make sense of the intersecting temporal and spatial
scales working on the human and more-than-human body, while
continuing to acknowledge race, class, and gender in terms of
global environmental justice and social inequality. The term toxic
timescapes refers to this intricate intersectionality of time,
space, and bodies in relation to toxic exposure. As a tool of
analysis, it unpacks linear understandings of time and explores how
harmful substances permeate temporal and physical space as both
event and process. It equips scholars with new ways of creating
data and conceptualizing the past, present, and future presence and
possible effects of harmful substances and provides a theoretical
framework for new environmental narratives. To think in terms of
toxic timescapes is to radically shift our understanding of
toxicants in the complex web of life. Toxicity, pollution, and
modes of exposure are never static; therefore, dose, timing,
velocity, mixture, frequency, and chronology matter as much as the
geographic location and societal position of those exposed.
Together, these factors create a specific toxic timescape that lies
at the heart of each contributor's narrative. Contributors from the
disciplines of history, human geography, science and technology
studies, philosophy, and political ecology come together to
demonstrate the complex reality of a toxic existence. Their case
studies span the globe as they observe the intersection of multiple
times and spaces at such diverse locations as former battlefields
in Vietnam, aging nuclear-weapon storage facilities in Greenland,
waste deposits in southern Italy, chemical facilities along the
Gulf of Mexico, and coral-breeding laboratories across the world.
In recent years, digital business models have frequently been the
subject of academic and practical discourse. The increasing
interconnectivity across the entire supply chain, which is subsumed
under the term Industry 4.0, can unlock even farther-reaching
potentials for digital business models, affecting entire supply
chains and ecosystems. This book examines the specific challenges
and obstacles that supply chain and ecosystem management poses with
regard to the development of digital business models. The
top-quality contributions gathered here focus on the successful
implementation of Industry 4.0 in digital business models for
industrial organizations in a European context, making the book a
valuable asset for researchers and practitioners alike.
This collection examines how the EU is seen in the two regions that
are at the centre of its geopolitical interest. Focusing on Eastern
Europe and sub-Saharan Africa, it provides a critical assessment of
how their external perceptions relate to EU policy towards them.
This monograph is based on the third author's lectures on computer
architecture, given in the summer semester 2013 at Saarland
University, Germany. It contains a gate level construction of a
multi-core machine with pipelined MIPS processor cores and a
sequentially consistent shared memory. The book contains the first
correctness proofs for both the gate level implementation of a
multi-core processor and also of a cache based sequentially
consistent shared memory. This opens the way to the formal
verification of synthesizable hardware for multi-core processors in
the future. Constructions are in a gate level hardware model and
thus deterministic. In contrast the reference models against which
correctness is shown are nondeterministic. The development of the
additional machinery for these proofs and the correctness proof of
the shared memory at the gate level are the main technical
contributions of this work.
Protein transport events occurring at the endoplasmic reticulum
(ER) of eukaryotic cells and the cytoplasmic membrane of
prokaryotic organisms share many similarities. Resident proteins of
both membranes span the lipid bilayer once or several times by
a-helical stretches and their integration is usually mediated by
uncleaved signal-anchor sequences. Proteins that are translocated
across either membrane, collectively also termed secretory
proteins, harbour cleavable N-terminal signal sequences.
Prokaryotic and eukaryotic signal sequences have the same modular
structure and are functionally exchangeable. Integration of
membrane proteins and translocation of secretory proteins basically
occur at the same sites (pores) within each membrane. In both types
of membranes, these pores are c- posed of homologous components
forming the Sec translocons. Parts of the Sec trans- cons are found
populated by ribosomes, the membrane-bound ribosomes. Bacterial m-
brane and eukaryotic secretory proteins are targeted to the Sec
translocons by the same molecular mechanism involving signal
recognition particle (SRP) and its receptor (SRP - ceptor, SR).
Structure and assembly of the SRP The functional core of SRP The
functional core of this ribonucleoprotein complex consists of the
signal sequence binding subunit (SRP54 in eukaryotes and Ffh in
prokaryotes) and the SRP RNA molecule (see Fig. 1). This core is
conserved in all organisms, with the intriguing exception of
chloroplasts, where the SRP lacks the RNA subunit.
The study of gouty arthritis has provided a common meeting ground
for the research interests of both the basic scientist and the
clinician. The interest of the chemist in gout began 1776 with the
isolation of uric acid from a concretion of the urinary tract by
the Swedish chemist SCHEELE. The same substance was subsequently
extracted from a gouty tophus by the British chemist WOLLASTONE in
1797 and a half century later the cause of the deposits of sodium
urate in such tophi was traced to a hyperuricemia in the serum of
gouty patients by the British physician Alfred Baring GARROD who
had also received training in the chemical laboratory and was
therefore a fore-runner of many of today's clinician-investigators.
The recent surge of progress in understanding of some of the causes
of gout in terms of specific enzyme defects marks the entrance of
the biochemist into this field of investigation. The identification
of the first primary defect of purine metabolism associated with
over-production of uric acid, a severe or partial deficiency of the
enzyme hypoxanthine-guanine phospho ribosyltransferase was achieved
less than a decade ago. The knowledge of the mechanism of purine
over-production that it generated led shortly to the identification
of families carrying a dominantly (possibly X-linked) inherited
increase in the activity of the enzyme phosphoribosylpyrophosphate
synthetase as a cause of purine over-production. Yet this is only a
start as these two types of enzyme defects account for less than
five per cent of gouty patients."
The study of gouty arthritis has provided a common meeting ground
for the research interests of both the basic scientist and the
clinician. The interest of the chemist in gout began 1776 with the
isolation of uric acid from a concretion of the urinary tract by
the Swedish chemist SCHEELE. The same substance was subsequently
extracted from a gouty tophus by the British chemist WOLLASTONE in
1797 and a half century later the cause of the deposits of sodium
urate In such tophi was traced to a hyperuricemia in the serum of
gouty patients by the British physician Alfred Baring GARROD who
had also received training in the chemical laboratory and was
therefore a fore-runner of many of today's clinician-investigators.
The recent surge of progress in understanding of some of the causes
of gout in terms of specific enzyme defects marks the entrance of
the biochemist into this field of investigation. The identification
of the first primary defect of purine metabolism associated with
over-production of uric acid, a severe or partial deficiency of the
enzyme hypoxanthine-guanine phospho ribosyl transferase was
achieved less than a decade ago. The knowledge of the mechanism of
purine over-production that it generated led shortly to the
identification of families carrying a dominantly (possibly
X-linked) inherited increase in the activity of the enzyme
phosphoribosylpyrophosphate synthetase as a cause of purine
over-production. Yet this is only a start as these two types of
enzyme defects account for less than five per cent of gouty
patients."
Volume VIII of Acta Historiae Neerlandicae again presents studies
on the history of the Low Countries which it is hoped will be of
interest to foreign scholars. The intention has been to deal with a
fairly long period, and many differing aspects, of the subject. So
institutional, political, economic, social and cultural history all
receive a fair share of attention, and together the studies cover a
considerable number of centuries. It is, however, striking to note
how even this restricted number of studies reflects prevailing
viewpoints among today's Low Countries' historians. Clearly there
is considerable stress on economic and social questions.
Traditional studies such as those of former Belgian historians on
medieval history, or those of the Dutch on the seventeenth century,
are now giving way to works that are problem directed. Power
structures, the position of the bourgeoisie, reactions of the
intelli gentsia and theologians to societal problems, have now more
attraction for scholars than the glories of late medieval wealth in
Flanders or Holland's Golden Age. Terms such as Guerilla warfare,
Struggle, Depression, typify today's critical approach to society
in general.
Protein transport events occurring at the endoplasmic reticulum
(ER) of eukaryotic cells and the cytoplasmic membrane of
prokaryotic organisms share many similarities. Resident proteins of
both membranes span the lipid bilayer once or several times by
a-helical stretches and their integration is usually mediated by
uncleaved signal-anchor sequences. Proteins that are translocated
across either membrane, collectively also termed secretory
proteins, harbour cleavable N-terminal signal sequences.
Prokaryotic and eukaryotic signal sequences have the same modular
structure and are functionally exchangeable. Integration of
membrane proteins and translocation of secretory proteins basically
occur at the same sites (pores) within each membrane. In both types
of membranes, these pores are c- posed of homologous components
forming the Sec translocons. Parts of the Sec trans- cons are found
populated by ribosomes, the membrane-bound ribosomes. Bacterial m-
brane and eukaryotic secretory proteins are targeted to the Sec
translocons by the same molecular mechanism involving signal
recognition particle (SRP) and its receptor (SRP - ceptor, SR).
Structure and assembly of the SRP The functional core of SRP The
functional core of this ribonucleoprotein complex consists of the
signal sequence binding subunit (SRP54 in eukaryotes and Ffh in
prokaryotes) and the SRP RNA molecule (see Fig. 1). This core is
conserved in all organisms, with the intriguing exception of
chloroplasts, where the SRP lacks the RNA subunit.
It is generally accepted that training in statistics must include
some exposure to the mechanics of computational statistics. This
learning guide is intended for beginners in computer-aided
statistical data analysis. The prerequisites for XploRe - the
statistical computing environment - are an introductory course in
statistics or mathematics. The reader of this book should be
familiar with basic elements of matrix algebra and the use of HTML
browsers. This guide is designed to help students to XploRe their
data, to learn (via data interaction) about statistical methods and
to disseminate their findings via the HTML outlet. The XploRe APSS
(Auto Pilot Support System) is a powerful tool for finding the
appropriate statistical technique (quantlet) for the data under
analysis. Homogeneous quantlets are combined in XploRe into
quantlibs. The XploRe language is intuitive and users with prior
experience of other sta tistical programs will find it easy to
reproduce the examples explained in this guide. The quantlets in
this guide are available on the CD-ROM as well as on the Internet.
The statistical operations that the student is guided into range
from basic one-dimensional data analysis to more complicated tasks
such as time series analysis, multivariate graphics construction,
microeconometrics, panel data analysis, etc. The guide starts with
a simple data analysis of pullover sales data, then in troduces
graphics. The graphics are interactive and cover a wide range of
dis plays of statistical data."
This book presents a formal model for evaluating the cost
effectiveness of computer architectures. The model can cope with a
wide range of architectures, from CPU design to parallel
supercomputers. To illustrate the formal procedure of trade-off
analyses, several non-pipelined design alternatives for the
well-known RISC architecture called DLX are analyzed
quantitatively. It is formally proved that the interrupt mechanism
proposed for the DLX architecture handles nested interrupts
correctly.
In an appendix all programs to compute the cost and cycle time of
the designs described are listed in C code. Running these simple C
programs on a PC is sufficient to verify the results presented. The
book addresses design professionals and students in computer
architecture.
In recent years, digital business models have frequently been the
subject of academic and practical discourse. The increasing
interconnectivity across the entire supply chain, which is subsumed
under the term Industry 4.0, can unlock even farther-reaching
potentials for digital business models, affecting entire supply
chains and ecosystems. This book examines the specific challenges
and obstacles that supply chain and ecosystem management poses with
regard to the development of digital business models. The
top-quality contributions gathered here focus on the successful
implementation of Industry 4.0 in digital business models for
industrial organizations in a European context, making the book a
valuable asset for researchers and practitioners alike.
In fast jedem klinischen Fachgebiet werden Blutprodukte
angewendet. Dennoch kommt die Transfusionsmedizin in der arztlichen
Ausbildung oft zu kurz. Dieses Buch bietet einen hervorragenden
Uberblick fur den nichttransfusionsmedizinischen Facharzt bzw.
Transfusionsbeauftragten im Umgang mit zellularen und plasmatischen
Blutprodukten. Neben Produktbeschreibungen, Indikationshinweisen,
pratransfusioneller Testbesprechung und Verabreichungshinweisen
werden auch das Nebenwirkungsspektrum von Blutkomponenten und die
konsekutiv dazu notwendigen Massnahmen, Transfusions-Notfalle
behandelt. Ebenso thematisiert werden die CMV-Problematik, die
perinatale / neonatale Bluttransfusion einschliesslich der
Rhesusprophylaxe, Plasmaderivate, Hamovigilanz und Look back. Die
Intention des Autors liegt in der bestmoglichen Vermittlung dieses
speziellen klinischen Wissensbereiches und in der optimalen Nutzung
blutgruppenserologisch-transfusionsmedizinischer Ressourcen."
Das Buch befasst sich mit der Bereitstellung von Daten und
Verfahren fur analytische Zwecke (Planung, Entscheidung,
Controlling sowie Fehlerruckverfolgung) in Unternehmen sowie der
notwendigen Rechenleistungen. Die Autoren erlautern die
Datenbereitstellung mittels Data Warehouses, Auswertung mittels
OLAP-Operationalitat und geeignete Verfahren der explorativen
Datenanalyse. Bei den Verfahren des Operations Research werden
Simulation und Lineare Optimierung dargestellt. Neben erfolgreichen
Anwendungen und Fallstudien steht das Verstandnis der
zugrundeliegenden Algorithmen und Datenstrukturen, die fur das
Erlernen der BI-Verfahren zwingend notwendig sind, im
Vordergrund."
Das Buch geht zunachst auf den Hintergrund und die Entwicklung der
EG-OEko-Audit-Verordnung ein. Anschliessend erfolgt eine breit
gefacherte Analyse von Anspruch und Wirklichkeit des seit nunmehr 3
Jahren angewandten Systems sowie der Entwicklung von
Umweltmanagementsystemen im allgemeinen. Die empirischen
Untersuchungen und Analysen geben allen beruflich Betroffenen,
Unternehmensvertretern und Wissenschaftlern einen umfassenden
UEberblick zum Stand und zur Entwicklung normierter
Umweltmanagementsysteme. Die abschliessende Diskussion von
Einzelaspekten fur die anstehende Revision der
EG-OEko-Audit-Verordnung rundet die kritische Auseinandersetzung
mit dem Themenfeld 'normiertes Umweltmanagement' ab.
Die bisherigen Debatten um Intersectionality haben gezeigt, dass
sich eine kontextunabhangige Definition von Intersektionalitat
nicht angeben lasst. Daruber hinaus bezeugt das ungebrochene
Interesse an dieser Debatte, dass es eines kritischen
Reflexionsinstrumentes von Ungleichheit und Differenz in
Wissenschaft und Politik bedarf. Was also ist das Verhaltnis von
Intersektionalitat und Kritik respektive kann Intersektionalitat
kritisch sein? Dieser Band behandelt die Frage in dreierlei
Hinsicht: Erstens wird Intersectionality im Spannungsfeld von
wissenschaftlichen und politischen Praktiken analysiert. Zweitens
wird Intersectionality als Methodenreflexion, das heisst als Kritik
an herkommlichen Methoden der jeweiligen Disziplinen, prasentiert.
Drittens werden Ansatze diskutiert, die Intersectionality als
kritisches Instrument fur die Reflexion von Geschichte und
Gesellschaft fruchtbar machen."
Dies ist die erste Monographie uber die Bruche des distalen
Unterschenkelsegmentes - vor allem die intraartikularen sogenannten
Pilon-tibial-Frakturen. Diese wurden bisher aufgrund ihrer
Seltenheit und Komplexitat noch nie in dieser Weise besprochen.
Auch die Klassifikation, operative Therapie und Prognose werden
dargestellt. Nach einer praxisorientierten anatomischen Einleitung
wird anhand des vielfaltigen Krankengutes der
AO-Dokumentationszentrale und gestutzt auf ausgedehnte eigene
Erfahrungen zunachst die Klassifikation erarbeitet und erlautert.
Diese schliesst sich eng an die von M.E. Muller et al. 1987
publizierte "Classification AO des Fractures" an. Das bei dieser
Lokalisation sehr spezielle Problem der artikularen Impression wird
eingehend behandelt. Es folgen eine Zusammenfassung der Geschichte
dieser Verletzungen und eine Ubersicht der bisherigen
Publikationen. Indikation, Technik und Problematik der oft
schwierigen operativen Behandlung werden ausfuhrlich wiedergegeben.
Spezielle Abschnitte uber neueste Auffassungen und Techniken,
sekundare Eingriffe und Arthrodesen wurden von Mitarbeitern des
Autors gestaltet. Ein Anhang enthalt die Detailanalyse des
verwerteten Krankengutes unter besonderer Berucksichtigung der
Prognose. Ziel des Buches ist es, traumatologisch aktive Chirurgen
und Orthopaden moglichst umfassend uber eine Verletzung zu
informieren, mit welcher sie nur relativ selten konfrontiert sind.
Die Einfachheit der Einteilung soll eine korrekte
Indikationsstellung und sorgfaltige Therapiewahl fordern unter
Berucksichtigung von Komplikationen und Prognose.
"Palliativ" = "lindernd," d.h. eine Behandlung, die zwar die
Symptome abschw{cht, ber nicht die Ursachen bek{mpft (bei
Krebskranken in fortgeschrittenem Stadium oft die einzige
Behandlungsm-glichkeit). Das bedeutet einen breiten thera-
peutischen Ansatz, der von allgemein-{rztlichen Aufgaben ausgeht
und }ber systematische und organbezogene Therapie zur Pflege,
sozialen Integration und F}hrung von Sterbenden reicht. Diese
Aspekte werden breit und interdisziplin{r dar- gestellt.
1m letzten Jahrzehnt seines Lebens hatte Max Miiller die nach der
Emeritierung begonnene Niederschrift seiner "Erinnerungen"
abgeschlossen und qualte sieh mit Uberlegungen, ob er sie selbst
noch veroffentlichen solIe. Auch seine Freun- de wuBten keinen Rat.
Was sie lasen, war etwas anderes als die gerade in diesen Jahren
erschienenen Autobiographien, mit denen sieh andere Vertreter des
Fa- ches einem breiteren Publikum durch literarische Gewandtheit,
temperament- volle Selbstdarstellung, interessante Lebenslaufe und
merkwiirdige FaIle emp- fahlen. Es war der eher schmucklose Bericht
iiber das halbe Jahrhundert eines von einem unverstellt-kraftvollen
Temperament in natiirlicher Weltoffenheit ge- lebten, aber zugleich
selbstkritisch-eigenwillig und mit zweiflerischer Sensibilitat
reflektierten Lebens - ein Bericht, der iiber die
psychiatriegeschichtliche Aus- gangsperspektive hinaus ein halbes
Jahrhundert Zeitgeschichte erfaBt hatte. In dem umfanglichen
Manuskript waren Informationen festgehalten, die nieht ver-
lorengehen durften. Man konnte aber auch die Stiirme voraussehen,
die sich ge- gen den Autor, dessen auf eigene Schwachen und Fehler
gerichtete Offenherzig- keit und gelegentliche Unverbliimtheit
andere noch lebende Zeitgenossen nicht aussparte, bei einer
Veroffentlichung erheben wiirden. Tilgen, zudecken und schonen
wollte er nieht. Uber dem Hin und Her der Diskussion ist das fiir
die Kenntnis der Psychiatrie seit dem Ende des ersten Weltkrieges
wichtige Manu- skript liegengeblieben. Es wird jetzt herausgegeben,
ohne Retuschen, doch mit manchen Streichungen, die von der
Riicksicht auf Angehorige bestimmt waren, und erweitert urn einen
Anhang, der im Text erwahnten Namen knappe ErUiute- rungen
beifiigt.
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