The structure of this sixth edition is simple and precise, yet strong and rigid. It is built around the experimentations, pure observations, valid interpretations and faithful deductions with an honest and sincere purpose. The mega experiment carried out by Hahnemann, single-handedly, for nearly fifty years, with a sole purpose of benefiting mankind. It has put the art and science of medicine on a scientific footing. It deals with three basic issues: what is curable in diseases and how to know that; what is curative in medicines and how to find that out; and, most importantly, how to apply the knowledge of medicines.