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This volume presents the recent developments on the biomedical
applications of chitosan and its derivatives. Chitosan exhibits
unique properties such as non-toxicity, biodegradability and
biocompatibility. Since its chemical structure and properties can
be easily modified, it can be an ideal candidate as a biomaterial.
Consequently, chitosan and its derivatives are being developed in
different forms such as nanoparticles, micelles, nanofibers,
hydrogels, films and 3D porous materials for various biomedical
applications, ranging from drug and gene delivery to tissue
engineering and regenerative medicine. The chapters of this volume
focus on the potential use of chitosan and its derivatives as a
hemostatic agent, tissue sealants, tissue engineering scaffolds,
delivery carriers for bioactive molecules in bone tissue
engineering and wound dressings. Some chapter's deal with recent
advancements of chitosan-based biomaterials as a drug, gene and
transdermal drug delivery carrier. In addition, the volume focusses
on the prospects of chitosan-based systems for the treatment of
cancer, eye and other infectious diseases. The volume will be of
interest to material scientists, chemists and biotechnologists by
providing a better understanding of the physicochemical and
biological characteristics of chitosan and its derivatives to
develop more appropriate and innovative chitosan-based materials
modified for unlimited practical applications in biomedical fields.
This volume deals with chemical modification, structure-property
relationship, biological interaction and biomedical applications of
chitosan and its chemically modified derivatives. The chapters of
this volume provide an overview of the structural comparison of
chitosan with other sugar-based biopolymers, a different type of
strategy used in chemical modification of chitosan to interact with
metal ions and to enhance antimicrobial activity. The chapters
further discuss the development of functionalized chitosan
hydrogels, films, scaffolds and composites that have the potential
to be used in food packaging, enhancing saltiness, biosensors and
wound dressing. In addition the fabrication and biological
properties of chitosan and its derivatives-based nanofibers are
presented. Another important aspect covered in this volume is that
of the interaction of chitosan with blood, platelet-rich plasma and
stem cells. Finally, this volume presents the current challenges in
the development of biomedical products based on chitosan and its
derivatives. The volume will be of interest to chemists, material
science, biological science and biomaterial scientists can able to
understand structure-property relationship, biological interaction
and biomedical applications of chitosan and its derivatives.
This volume presents the recent developments on the biomedical
applications of chitosan and its derivatives. Chitosan exhibits
unique properties such as non-toxicity, biodegradability and
biocompatibility. Since its chemical structure and properties can
be easily modified, it can be an ideal candidate as a biomaterial.
Consequently, chitosan and its derivatives are being developed in
different forms such as nanoparticles, micelles, nanofibers,
hydrogels, films and 3D porous materials for various biomedical
applications, ranging from drug and gene delivery to tissue
engineering and regenerative medicine. The chapters of this volume
focus on the potential use of chitosan and its derivatives as a
hemostatic agent, tissue sealants, tissue engineering scaffolds,
delivery carriers for bioactive molecules in bone tissue
engineering and wound dressings. Some chapter's deal with recent
advancements of chitosan-based biomaterials as a drug, gene and
transdermal drug delivery carrier. In addition, the volume focusses
on the prospects of chitosan-based systems for the treatment of
cancer, eye and other infectious diseases. The volume will be of
interest to material scientists, chemists and biotechnologists by
providing a better understanding of the physicochemical and
biological characteristics of chitosan and its derivatives to
develop more appropriate and innovative chitosan-based materials
modified for unlimited practical applications in biomedical fields.
Polymeric Bionanocomposites as Promising Materials for Controlled
Drug, by M. Prabaharan, R. Jayakumar; Chitosan and Chitosan
Derivatives in Drug Delivery and Tissue Engineering, by R. Riva, H.
Ragelle, A. des Rieux, N. Duhem, C. Jerome, and V. Preat; Chitosan:
A Promising Biomaterial for Tissue Engineering Scaffolds, by P. K.
Dutta, K. Rinki and J. Dutta; Chitosan-Based Biomaterials for
Tissue Repair and Regeneration, by X. Liu, L. Ma, Z. Mao and C.
Gao; Use of Chitosan as a Bioactive Implant Coating for
Bone-Implant Applications, by M. R. Leedy, H. J. Martin, P. A.
Norowski, J. A. Jennings, W. O. Haggard, and J.D. Bumgardner; New
Techniques for Optimization of Surface Area and Porosity in
Nanochitins and Nanochitosans, by R. A. A. Muzzarelli; Production,
Properties and Applications of Fungal Cell Wall Polysaccharides:
Chitosan and Glucan, by N. New, T. Furuike, and H. Tamura;"
Polymeric Nanoparticles of Chitosan Derivatives as DNA and siRNA
Carriers, by Y. K. Kim, H. L. Jiang, Y. J. Choi, I. K. Park, M. H.
Cho and C. S. Cho.- Chitosan and Its Derivatives for Drug Delivery
Perspective, by T. A. Sonia and C. P. Sharma.- Chitosan-based
Nanoparticles in Cancer Therapy, by V.-K. Lakshmanan, K. S. Snima,
J. D. Bumgardner, S. V. Nair, and R. Jayakumar.- Chitosan and
Thiolated Chitosan, by F. Sarti and A. Bernkop-Schnurch.-
Chitosan-Based Particulate Systems for Non-Invasive Vaccine
Delivery, by S. enel.- Multifunctional Chitosan Nanoparticles for
Tumor Imaging and Therapy, by J. Y. Yhee, Heebeom Koo, Dong Eun
Lee, Kuiwon Choi, Ick Chan Kwon and Kwangmeyung Kim.-
Chitosan-Coated Iron Oxide Nanoparticles for Molecular Imaging and
Drug Delivery, by H. Arami, Z. Stephen, O. Veiseh and M. Zhang.-
Chitosan: Its Applications in Drug-Eluting Devices, by Mei -Chin
Chen, Fwu -Long Mi, Zi -Xian Liao and Hsing -Wen Sung.-"
Polymeric Nanoparticles of Chitosan Derivatives as DNA and siRNA
Carriers, by Y. K. Kim, H. L. Jiang, Y. J. Choi, I. K. Park, M. H.
Cho and C. S. Cho.- Chitosan and Its Derivatives for Drug Delivery
Perspective, by T. A. Sonia and C. P. Sharma.- Chitosan-based
Nanoparticles in Cancer Therapy, by V.-K. Lakshmanan, K. S. Snima,
J. D. Bumgardner, S. V. Nair, and R. Jayakumar.- Chitosan and
Thiolated Chitosan, by F. Sarti and A. Bernkop-Schnurch.-
Chitosan-Based Particulate Systems for Non-Invasive Vaccine
Delivery, by S. Senel.- Multifunctional Chitosan Nanoparticles for
Tumor Imaging and Therapy, by J. Y. Yhee, Heebeom Koo, Dong Eun
Lee, Kuiwon Choi, Ick Chan Kwon and Kwangmeyung Kim.-
Chitosan-Coated Iron Oxide Nanoparticles for Molecular Imaging and
Drug Delivery, by H. Arami, Z. Stephen, O. Veiseh and M. Zhang.-
Chitosan: Its Applications in Drug-Eluting Devices, by Mei -Chin
Chen, Fwu -Long Mi, Zi -Xian Liao and Hsing -Wen Sung.-
This volume deals with chemical modification, structure-property
relationship, biological interaction and biomedical applications of
chitosan and its chemically modified derivatives. The chapters of
this volume provide an overview of the structural comparison of
chitosan with other sugar-based biopolymers, a different type of
strategy used in chemical modification of chitosan to interact with
metal ions and to enhance antimicrobial activity. The chapters
further discuss the development of functionalized chitosan
hydrogels, films, scaffolds and composites that have the potential
to be used in food packaging, enhancing saltiness, biosensors and
wound dressing. In addition the fabrication and biological
properties of chitosan and its derivatives-based nanofibers are
presented. Another important aspect covered in this volume is that
of the interaction of chitosan with blood, platelet-rich plasma and
stem cells. Finally, this volume presents the current challenges in
the development of biomedical products based on chitosan and its
derivatives. The volume will be of interest to chemists, material
science, biological science and biomaterial scientists can able to
understand structure-property relationship, biological interaction
and biomedical applications of chitosan and its derivatives.
Polymeric Bionanocomposites as Promising Materials for Controlled
Drug, by M. Prabaharan, R. Jayakumar; Chitosan and Chitosan
Derivatives in Drug Delivery and Tissue Engineering, by R. Riva, H.
Ragelle, A. des Rieux, N. Duhem, C. Jerome, and V. Preat; Chitosan:
A Promising Biomaterial for Tissue Engineering Scaffolds, by P. K.
Dutta, K. Rinki and J. Dutta; Chitosan-Based Biomaterials for
Tissue Repair and Regeneration, by X. Liu, L. Ma, Z. Mao and C.
Gao; Use of Chitosan as a Bioactive Implant Coating for
Bone-Implant Applications, by M. R. Leedy, H. J. Martin, P. A.
Norowski, J. A. Jennings, W. O. Haggard, and J.D. Bumgardner; New
Techniques for Optimization of Surface Area and Porosity in
Nanochitins and Nanochitosans, by R. A. A. Muzzarelli; Production,
Properties and Applications of Fungal Cell Wall Polysaccharides:
Chitosan and Glucan, by N. New, T. Furuike, and H. Tamura;"
Chitosan, a natural based polymer obtained by alkaline
deacetylation of chitin, is non-toxic, biocompatible, and
biodegradable. These properties make chitosan a good candidate for
the development of conventional and novel drug delivery systems.
Recently, there has been a growing interest in the chemical
modification of chitosan in order to improve its solubility and
widen its applications. Chemical modification of chitosan is useful
for the association of bioactive molecules to the polymer and
controlling the drug release profile. Chemical modification will
introduce desired properties and enlarge the field of the potential
applications of chitosan with the choice of various types of side
chains.
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