The roles of gene transcription in cancer have long been appreciated. However, posttranscriptional processes also contribute significantly to alterations in gene expression that lead to tumor initiation, formation, and progression.We have known for decades that alterations in the expression of key genes, such as those involved in cell proliferation, signaling, apoptosis, and immune responses, are major molecular events in cancer. This book presents our current understanding of selected posttranscriptional control mechanisms and the RNAs that they regulate. Each chapter provides an overview of a specific RNA-directed regulatory system and the RNA/protein factors involved, then discusses major findings in the field and their relationships to the development and/or treatment of cancer and associated diseases. Future questions serve to address 'where do we go from here' and stimulate the reader's thinking about these important problems.This compendium of chapters from experts in the field is essential reading for anyone interested in the myriad ways that RNAs contribute to tumorigenesis: from graduate students, researchers, and clinical scientists interested in mRNA processing and translation, RNA-binding proteins that promote turnover/stability of specific mRNAs, how small noncoding RNAs control inflammation and signaling, roles of the epitranscriptome, and future and emerging RNA-based, anti-tumor therapeutics.

The first publication of Ernest Cole’s photographs depicting Black lives in the United States during the turbulent and eventful late 1960s and early ’70s After the publication of his landmark 1967 book House of Bondage on the horrors of apartheid, Ernest Cole moved to New York and received a grant from the Ford Foundation to document Black communities in cities and rural areas of the United States. He released very few images from this body of work while he was alive. Thought to be lost entirely, the negatives of Cole’s American pictures resurfaced in Sweden in 2017. Ernest Cole photographed extensively in New York City, documenting the lively community of Harlem, including a thrilling series of color photographs, as he turned his talent to street photography across Manhattan. In 1968 Cole traveled to Chicago, Cleveland, Memphis, Atlanta, and Los Angeles, as well as rural areas of the South, capturing the mood of different Black communities in the months leading up to and just after the assassination of Martin Luther King Jr. The pictures both reflect a newfound hope and freedom that Cole felt in America, and an incisive eye for inequality as he became increasingly disillusioned by the systemic racism he witnessed. This treasure trove of rediscovered work provides an important window into American society and redefines Cole’s oeuvre, presenting a fuller picture of the life and work of a man who fled South Africa and exposed life under apartheid to the world.

Victor Perkins (1936-2016) was a foundational figure for the study of film both as a writer and as an educationalist and teacher who played a key role in establishing film within British higher education. Best known for his 1972 book Film as Film, Perkins has a worldwide reputation within film studies that has been enhanced in recent years by the interest among emerging scholars in the practices of detailed film criticism. His extensive writing in journals and edited collections, spanning sixty years, is less well known, despite its importance and quality, partly because much of it was published in small magazines with limited distribution. V. F. Perkins on Movies: Collected Shorter Film Criticism, edited by Douglas Pye, makes it possible to see his writing as a coherent body of work, developed over a long career, and to appreciate its great historical and cultural significance. Part 1 of the book covers Perkins's early articles from 1960 to 1972, showing the emergence of ways of thinking about criticism and movies that remained constant throughout his career. Perkins was one of a small group of British writers who pioneered the serious and systematic discussion of Hollywood cinema. Beginning at the University of Oxford in the pages of Oxford Opinion, and then in Movie, the journal they established in 1962, these writers mounted a sustained critique of established writing on film, arguing for a criticism rooted in the detailed decisions that make up the complex texture of a film. The work Perkins published in the 1980s and beyond, which makes up part 2 of this volume, was resolute in upholding his critical values. It elaborated his approach in studies of individual movies and their makers and also reflected on major critical and conceptual issues, while maintaining his lifelong commitment to writing accessibly in ordinary language. V. F. Perkins on Movies gives unimpeded access to one of the most distinctive and distinguished of critical voices and will be widely welcomed by academics, students of film, and informed film enthusiasts.

Ireland has long been a country of conflict. More than 400 years ago, the occupying English "planted" pre-Celtic Scots in the northern province of Ulster and divested the native Irish Celts of the land their ancestors owned for 2,000 years. This created a deep-seated enmity between the English and Irish, Protestant and Catholic-and it finally exploded in the Troubles.

Author Alan M. Wilson was on the front lines for the bloodbath that tore Northern Ireland apart from the late 1960s through the first years of the twenty-first century. Policing Ireland's Twisted History reveals Wilson's remarkable, true story of growing up in Belfast and serving in the Royal Ulster Constabulary as an inspector and as a member of an elite anti-terrorism unit. Wilson's only goal was to help protect the innocent on both sides. Unfortunately, he became a target himself.

Brutally honest and unflinching, Wilson traces his experiences serving Ireland's divided society for nearly ten years. From watching friends die to the tit-for-tat murders occurring on the streets to staring death in the eye more than once, Wilson reveals the deep, gut-wrenching search for the meaning of it all in the midst of the world's longest-running terrorist situation.

A firsthand look at the Northern Ireland conflict, "Policing Ireland's Twisted History" offers an eye-opening, intimate examination of this devastating struggle.

Alcohol is not only big business, it has become an essential part of social relations in so many cultures that its global importance may be outdistancing its critics. Despite grim health warnings, its consumption is at an all-time high in many parts of the developed world. Perhaps because drinking has always played a key role in identity, its uses and meanings show no signs of abating. What does sake tell us about Japan or burgundy about France? How does the act of consuming or indeed abstaining from alcohol tie in with self-presentation, ethnicity, class and culture? How important is alcohol to feelings of belonging and notions of resistance?Answering these intriguing questions and many more, this timely book looks at alcohol consumption across cultures and what drinking means to the people who consume or, equally tellingly, refuse to consume. From Ireland to Hong Kong, Mexico to Germany, alcohol plays a key role in a wide range of functions: religious, familial, social, even political. Drinking Cultures situates its consumption within the context of these wider cultural practices and reveals how class, ethnicity and nationalism are all expressed through this very popular commodity. Drawing on original fieldwork, contributors look at the interplay of culture and power in bars and pubs, the significance of advertising symbols, the role of drink in day-to-day rituals and much more. The result is the first sustained, cross-cultural study of the profound impact alcohol has on national identity throughout the world today.

This book is the result of investiging whether Ode to a Nightingale could be interpreted as the record of an actual song that moved Keats so deeply as to involve, in Jung's terms, an experience of the Self. . It is in effect a biographical study of one aspect of Keats' life of the imagination. It suggests why he became a poet, shows how his attitude to his poetry changed, how in Jungian terms he first met his 'shadow', rejected it, then came to accept it, and how this affected his poetry. The meaning of the few psychological terms used in the book are clarified by illustration from Keats' own writing, thus contributing to its understanding at the same time. An intimate relationship between his letters and the poems is shown. First published in 1964, the study throws light on well-worn themes such as what Keats meant by beauty, his theory of 'negative capability', why he abandoned Hyperion. It gives a fresh interpretation of Endymion and of aspects of the two versions of Hyperion, Lamia, The Eve of St Agnes, and the other great odes. Among details is has something to say on why La Belle Dame kissed her knight precisely four times.

This collection explores the nature and role of ethics within anarchist thought and practice, examining normative, meta-ethical and applied ethical issues through some of the theoretical insights of anarchism. It comprises contributions from international scholars working within the fields of philosophy and political theory.

This pioneering collection of articles presents a fresh look at the life, work and seminal contributions of Margaret H'Doubler, the pioneering dance educator who established the first dance major in higher education at the University of Wisconsin-Madison in 1926. This anthology is unique, given that it is the first thorough critique of Margaret H'Doubler's life, career, and philosophies. The book is also timely in its inclusion of so many authentic voices, speaking from their first hand experience with the master from as early as the late 1920s to the present, now twenty-three years after H'Doubler's death. The book completes a task that is due any original thinker and practitioner in the course of her or his lifetime, but remarkably, was not in the case of Margaret H'Doubler. Margaret H'Doubler is a significant new contribution to the historic record, and an extraordinary resource for dance scholars, educators and students.

Incorporating both archaeological and ethnohistorical evidence, this volume reexamines the role played by native peoples in structuring interaction with Europeans. The more complete historical picture presentedwill be of interest to scholars and students of archaeology, anthropology, and history.

When marketing managers and financial managers join forces within any business, the result can often be poor communication on financial criteria and goals. The risk of this situation occurring is inevitably present when those with different professional backgrounds and roles are working in accordance with their own norms. In his seminal 1956 paper on general systems theory, the economist Kenneth Boulding referred to the phenomenon of "specialised ears and generalised deafness", which can be seen to exist when marketing managers are financially illiterate or when financial managers lack the necessary insights to design, implement and operate accounting systems which are useful to marketing managers in carrying out their roles. It is increasingly difficult to attach credence to the idea of marketing managers who lack financial skills, or financial managers who fail to relate to the context in which marketing managers operate. Understanding the marketing/accounting interface is therefore important in generating emergent properties from the interaction of marketers and accountants whereby the whole is greater than the sum of the parts. The chapters in this volume seek to address this challenge. This book was originally published as a special issue of the Journal of Marketing Management.

When marketing managers and financial managers join forces within any business, the result can often be poor communication on financial criteria and goals. The risk of this situation occurring is inevitably present when those with different professional backgrounds and roles are working in accordance with their own norms. In his seminal 1956 paper on general systems theory, the economist Kenneth Boulding referred to the phenomenon of "specialised ears and generalised deafness", which can be seen to exist when marketing managers are financially illiterate or when financial managers lack the necessary insights to design, implement and operate accounting systems which are useful to marketing managers in carrying out their roles. It is increasingly difficult to attach credence to the idea of marketing managers who lack financial skills, or financial managers who fail to relate to the context in which marketing managers operate. Understanding the marketing/accounting interface is therefore important in generating emergent properties from the interaction of marketers and accountants whereby the whole is greater than the sum of the parts. The chapters in this volume seek to address this challenge. This book was originally published as a special issue of the Journal of Marketing Management.

Audit professionals are valued members of society and are expected to be both skilled and ethical in their decision-making. The role of the auditor extends far beyond that of counting beans by demanding a social and political awareness, a technical knowledge, ethical principles and relationship skills. In addition, due to the team-oriented nature of the audit approach, auditors require strong team-building and interpersonal skills. This book offers expert descriptions of, and insights into, how such skills and responsibilities can be inculcated in tertiary education and professional training environments. Unlike other books which focus on auditing as a technical process, this volume examines auditing from a teaching and learning perspective. Expert contributors provide authoritative insights into an audit education which is embedded in accounting practice. The book's descriptions of these insights into improving education for future audit professionals may allow the introduction of new and challenging fields of enquiry. Audit Education will be of great interest to educators in tertiary institutions, trainers in professional firms, and key individuals in accounting professional bodies seeking to ensure their members possess acceptable levels of attainment for admission and continued membership. This book was originally published as a special issue of Accounting Education: an international journal.

The Power of Collaborative Leadership: Lessons for the Learning Organization helps business leaders realize the promise of organizational learning by sharing the lessons, insights, and best practices gained by two veteran managers and organizational learning pioneers. The book makes organizational learning principles and concepts more concrete by grounding them in the practical experiences of two major companies. The Power of Collaborative Leadership helps business leaders realize the promise of organizational learning by sharing lessons, insights, and best practices gained by Bert Frydman and Iva Wilson, two veteran managers and organizational learning pioneers. Together with JoAnne Wyer, a professional learning analyst, they show that in order to be effective leaders of business organizations, we must transform an organization's methods of absorbing new information and its ability to transform it into knowledge and wisdom. This book offers some provocative and practical ways to overcome many commonly held assumptions and practices that can actually impede learning and the improvement of the organization.