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Cyclic nucleotide phosphodiesterases (PDEs) are promising targets
for pharmacological intervention. Multiple PDE genes, isoform
diversity, selective expression and compartmentation of the
isoforms, and an array of conformations of PDE proteins are
properties that challenge development of drugs that selectively
target this class of enzymes. Novel characteristics of PDEs are
viewed as unique opportunities to increase specificity and
selectivity when designing novel compounds for certain therapeutic
indications. This chapter provides a summary of the major concepts
related to the design and use of PDE inhibitors.
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Wireless On-Demand Network Systems - First IFIP TC6 Working Conference, WONS 2004, Madonna di Campiglio, Italy, January 21-23, 2004, Proceedings (Paperback, 2004 ed.)
Roberto Battiti, Marco Conti, Renato Lo Cigno
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R1,762
Discovery Miles 17 620
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Ships in 10 - 15 working days
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Thisbookcontainstherefereedproceedingsofthe1stIFIP-TC6WorkingCon-
rence on Wireless-On-Demand Network Systems, WONS 2004. It was
sponsored by the IFIP Working Groups 6.3 (Performance of Computer
and Commu- cation Networks)and6.8(Mobile and Wireless
Communications), and aimed at becoming a premier international
forum for discussions between researchers and practitioners
interested in the evolution of Wireless Internet Access toward
on-demand networking. Ad hoc, routing, localization, resource
management, - curity, applications, performance and analytical
models were topics covered in depth by technical papers in this
book. Theconferencereceived77submissionsfrom22countries,
showingthewor- wide interest. With so many papers to choose from,
the Technical Program Committee s job, providing a conference
program with the highest quality, was challenging and time
consuming. We ?nally selected 25 full papers for presen- tion in
the conference technical sessions. To give researchers the
opportunity to present the novel ideas they are starting to
explore, we included in the technical program a poster session
devoted to presenting preliminary research results: 7 short papers
were selected for presentation in this session. Accepted papers and
posters came from 15 di?erent countries. The technical program also
included a keynote speech Ad Hoc Wireless Networks: Protocols and
Applications by Prof. Mario Gerla, and a panel s- sion devoted to
the discussion of the conference topics between academics and
industry representatives. This event would not have been possible
without the enthusiasm and hard work of a number of colleagues. A
special thanks to the TPC members, and all the referees, for their
invaluable help in reviewing the papers for WONS 2004."
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Personal Wireless Communications - IFIP-TC6 8th International Conference, PWC 2003, Venice, Italy, September 23-25, 2003, Proceedings (Paperback, 2003 ed.)
Marco Conti, Silvia Giordano, Enrico Gregori, Stephan Olariu
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R3,187
Discovery Miles 31 870
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Ships in 10 - 15 working days
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This book constitutes the refereed proceedings of the IFIP-TC6
Eighth - ternational Conference on Personal Wireless
Communications, PWC 2003. PWC 2003 is the ?agship conference of the
IFIP Working Group 6.8, Mobile and Wireless Communications, and is
the premier international forum for discussions between
researchers, practitioners, and students interested in the
symbiosis of mobile computing and wireless networks. It is a great
pleasure to present the PWC 2003 technical program. This year the
conference received 115 submissions from 27 countries indicating
that PWC is a reference conference for worldwide researchers from
the wireless and mobile community. With so many papers to choose
from, the Technical Program Committee s job, to provide a
conference program of the highest technical quality, was
challenging and time consuming. From the 115 submissions, we ?nally
selected 34 full papers and 15 short papers for presentation in the
conference technical sessions. The conference technical program was
split into three days, and included, in addition to the 49 refereed
contributions, 4 invited papers from top-level researchers from the
mobile and wireless community. To give researchers the opportunity
to present ongoing work, and the novel ideas they are starting to
explore, we included in the technical program two work-in-progress
sessions and two novel-ideas sessions. The technical program also
included a poster session devoted to presenting ongoing research
projects on wireless and mobile communications."
Online Social Networks: Human Cognitive Constraints in Facebook and
Twitter provides new insights into the structural properties of
personal online social networks and the mechanisms underpinning
human online social behavior. As the availability of digital
communication data generated by social media is revolutionizing the
field of social networks analysis, the text discusses the use of
large- scale datasets to study the structural properties of online
ego networks, to compare them with the properties of general human
social networks, and to highlight additional properties. Users will
find the data collected and conclusions drawn useful during design
or research service initiatives that involve online and mobile
social network environments.
The book of Job presents its readers with a profound drama
concerning innocent suffering. Such honest, forthright wrestling
with evil and the silence of God has intrigued a wide range of
readers, both religious and nonreligious. Surprisingly, the
earliest fathers showed little interest in the book of Job. Not
until Origen in the early third century is there much evidence of
any systematic treatment of the book, and most of Origen's
treatment is known to us only from the catenae. More intense
interest came at the end of the fourth century and the beginning of
the fifth. The excerpts in this collection focus on systematic
treatment. Among Greek texts are those from Origen, Didymus the
Blind, Julian the Arian, John Chrysostom, Hesychius of Jerusalem
and Olympiodorus. Among Latin sources we find Julian of Eclanum,
Philip the Priest and Gregory the Great. Among Syriac sources we
find Ephrem the Syrian and Isho?dad of Merv, some of whose work is
made available here for the first time in English. In store for
readers of this volume is once again a great feast of wisdom from
the ancient resources of the church.
The church fathers, as they did in earlier books dealing with
Israel's history from the time of Joshua to the united monarchy,
found ample material for typological and moral interpretation in
1-2 Kings, 1-2 Chronicles, Ezra, Nehemiah and Esther. It will be
immediately clear to readers of this volume that they gave much
more attention to 1-2 Kings than to others; whether this was due to
a certain repetitiveness in the story line or other reasons is
unclear. But the narratives of wise King Solomon, the construction
of the temple, the prophets Elijah and Elisha, and the fates of
various faithful and unfaithful kings and other powerful people
were well suited to their purposes. Among Greek commentators in
this Ancient Christian Commentary on Scripture volume, readers will
find Justin Martyr, Clement of Alexandria, Origen, Methodius,
Eusebius of Caesarea, Athanasius, Cyril of Jerusalem, Basil the
Great, Gregory of Nazianzus, John Chrysostom, Cyril of Alexandria,
Theodoret of Cyr, Procopius of Gaza and John the Monk. Among Latin
commentators are Tertullian, Cyprian, Novatian, Lactantius,
Ambrose, Jerome, Prudentius, Augustine, Paulinus of Nola, John
Cassian, Peter Chrysologus, Maximus of Turin, Salvian the
Presbyter, Fulgentius of Ruspe, Caesarius of Arles, Gregory the
Great, Bede and Rabanus Maurus. Syriac commentators include
Aphrahat, Ephrem, Sahdona, Isaac of Nineveh and Isho'dad of Merv.
Together they set before readers a table of delights and
theological insights, some of which are here available to English
readers for the first time.
Mobile Multi-hop Ad Hoc Networks are collections of mobile nodes
connected together over a wireless medium. These nodes can freely
and dynamically self-organise into arbitrary and temporary,
"ad-hoc" network topologies, allowing people and devices to
seamlessly internetwork in areas with no pre-existing communication
infrastructure, (e.g., disaster recovery environments). The aim of
this book is to present some of the most relevant results achieved
by applying an experimental approach to the research on multi-hop
ad hoc networks. The unique aspect of the book is to present
measurements, experiences and lessons obtained by implementing ad
hoc networks prototypes.
Contents: 1. Introduction. - 2. Mobileman Architecture. - 3.
Wireless Technologies. - 4. Networking. - 5. Cooperation Models and
Mechanisms. - 6. Middelware. - 7. Applications. - 8. Economic
Models. - 9. Mesh Networks.
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