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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Phosphodiesterases as Drug Targets (Paperback, 2011 ed.)
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Phosphodiesterases as Drug Targets (Paperback, 2011 ed.)
Series: Handbook of Experimental Pharmacology, 204
Expected to ship within 10 - 15 working days
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Cyclic nucleotide phosphodiesterases (PDEs) are promising targets
for pharmacological intervention. Multiple PDE genes, isoform
diversity, selective expression and compartmentation of the
isoforms, and an array of conformations of PDE proteins are
properties that challenge development of drugs that selectively
target this class of enzymes. Novel characteristics of PDEs are
viewed as unique opportunities to increase specificity and
selectivity when designing novel compounds for certain therapeutic
indications. This chapter provides a summary of the major concepts
related to the design and use of PDE inhibitors.
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