Phosphodiesterases as Drug Targets (Paperback, 2011 ed.)

Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Handbook of Experimental Pharmacology, 204
Release date:	November 2013
First published:	2011
Editors:	Sharron H. Francis • Marco Conti • Miles D. Houslay
Dimensions:	235 x 155 x 28mm (L x W x T)
Format:	Paperback
Pages:	522
Edition:	2011 ed.
ISBN-13:	978-3-642-26945-5
Categories:	Books > Medicine > Other branches of medicine > Pharmacology > General Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Books > Science & Mathematics > Biology, life sciences > Cellular biology > General
LSN:	3-642-26945-1
Barcode:	9783642269455

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