Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. "Ocular Toxicity in Laboratory Animals" provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes.

The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, "Ocular Toxicity in Laboratory Animals" is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies."

A powerful new addition to the bestselling Gothic Fantasy series of new writing and classic stories. Buried treasure, greed and envy are powerful forces in the minds of many, but at sea the consequences can be terrifying and deadly. With tales of pirates, deathly fogs and ferocious rocks, these dark tales of the haunted mind, trapped like ghosts at sea, are sure to entertain and enthrall. These new authors appear alongside the following classic and essential writers: Joseph Conrad, James Fenimore Cooper, Stephen Crane, F. Marion Crawford, Arthur Conan Doyle, William Hope Hodgson, Homer, W.W. Jacobs, Rudyard Kipling, Vernon Lee, H.P. Lovecraft, Richard Middleton, Edgar Allan Poe, Robert Louis Stevenson, H.G. Wells.

Children with low self-esteem will have difficulty in partaking in classroom lessons and succeeding. If we want to help children in the primary school to achieve the positive outcomes set out in the Every Child Matters agenda, we need to ensure all children have a healthy self-esteem. This book seeks to give adults in schools tools to look at the way they could enhance self esteem in children. The book comes with an accompanying CD-Rom which contains: - inset sessions for all adults in the school - workshops specifically aimed at non-teaching personnel, including mid-day supervisors - sessions for teachers and classroom assistants - classroom lessons and activity sheets for the children which can form part of your school's personal, social and health education (PSHE) programme. This book is a whole school training programme for raising self-esteem and is essential reading for all those working in primary education. Margaret Collins is a former headteacher of infant and first schools. She is now Senior Visiting Fellow in the School of Education at the University of Southampton. She researches children's perceptions of health education topics, writes teaching materials for children, books and articles on PSHE.

Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.

Lucie Aubrac (1912-2007), of Catholic and peasant background, was teaching history in a Lyon girls' school and newly married to Raymond, a Jewish engineer, when World War II broke out and divided France. The couple, living in the Vichy zone, soon joined the Resistance movement in opposition to the Nazis and their collaborators. Outwitting the Gestapo is Lucie's harrowing account of her participation in the Resistance: of the months when, though pregnant, she planned and took part in raids to free comrades—including her husband, under Nazi death sentence—from the prisons of Klaus Barbie, the infamous Butcher of Lyon. Her book is also the basis for the 1997 French movie, Lucie Aubrac, which was released in the United States in 1999.   Purchase the audio edition.

Critical acclaim for Sisters in the Resistance

"Often moving . . . always fascinating . . . women in the French Resistance is a key subject. Margaret Weitz has gathered personal testimonies . . . and set them in an intelligible context that helps us understand how all French people—men and women—experienced the Nazi occupation." —Robert Paxton, Mellon Professor of Social Sciences, Columbia University, and author of Vichy France: Old Guard and New Order, 1940-1944.

"Compulsive reading . . . a valuable book which vividly portrays the intricacies of resistance within France, written in an easy but serious style." —Times Literary Supplement (London).

"An absolutely stunning and compelling chronicle of dauntless courage and unflagging patriotism." —Booklist.

"[Margaret Collins Weitz's] well-researched, thoughtful study. . . has filled a gap in the history of World War II." —Publishers Weekly.

"Balancing absorbing narrative and astute analysis, Margaret Collins Weitz has integrated the unsung achievements of women into the history of the French Resistance." —Carole Fink, Professor of History, The Ohio State University, and author of Marc Bloch: A Life in History.

"Fifty years after the end of World War II, Sisters in the Resistance renders homage to the courageous women of the French Resistance. It is high time for their contributions to be fully acknowledged, and fortunate indeed that they have found such a sympathetic, scholarly, and lucid chronicler in Margaret Collins Weitz." —Marilyn Yalom, author of Blood Sisters: The French Revolution in Women's Memory.

What effect did the two world wars have on the relations between women and men? Drawing on broad comparative material-from government policy to popular media, poetry and fiction, and personal letters-this book examines the redefinition of gender that occurred in many Western countries during both world wars. "A major addition to the literature on gender relations and war."-Helena Lewis, Women's Review of Books "One of the first, and certainly the most exciting, treatments of war as an event of gender politics."-Choice "A substantial contribution to the social history of this century."-Anne Summers, Times Literary Supplement "These essays powerfully demonstrate how much the world wars provided battlegrounds not only for nations but for the sexes."-Michael S. Sherry, Annals of the American Academy of Political and Social Science "A work of lively, engaged scholarship.... This is an important contribution to current debates about war and human identity, war and political reality, war and transformative possibility."-Jean Bethke Elshtain

Dehydrogenases are enzymes that play an important role in oxidation reactions. Dehydrogenases are involved in many metabolic pathways which maintain normal function and homeostasis of cells in the body. This book discusses the biochemistry of dehydrogenases, as well as their functions and roles in diseases.

This volume brings together a group of essays that examine the relationship between philosophy and literature - disciplines that have been opposed as often as they have been combined. While the focus is primarily on the plays of Shakespeare, there is a lengthy essay on the use of the style term maniera in art history, and a concluding survey and analysis of the relationship between philosophy and literature, from Plato to the present. The author applies the theory of meaning and logical analysis to contemporary problems in the arts and aesthetics.

Circle Time for the Very Young has been used by teachers and practitioners alike for the last ten years Now in its Third Edition, this book has been fully updated and includes a CD Rom to help you with Circle Time in your early years setting.

Circle Time is used to help form positive relationships, increase confidence and self-esteem and provide a safe environment to explore feelings and opinions.

Covering the 3 to 9 age range and focused on the core PSHE themes this book contains the following to help you establish, and maintain, circle time in your setting: an explanation of circle time and how it works, over 100 plans for different circle time sessions, different plans for both young and older children, activity sheets to use at the end of each session, and evaluation sheets to use at the end of the each theme.

All the activity and evaluation sheets can be printed from the new CD-Rom making it an ideal resource for those that want to use circle time but don't have time to plan the sessions.

This book is easily used in any setting and is a must-have for busy practitioners.

Citizenship education equips children with the skills necessary to play an active part in society and act as socially and morally responsible citizens. Margaret Collins has used her considerable experience to create another fantastic age appropriate practical resource for children aged 4-9 that widens the concept of citizenship so that it incorporates global issues. The book explores six topics: - Basic needs - Environmental issues - Fairness - Exploring various cultures - Democracy - Global issues. Each section has an introductory page and ideas for resources, followed by activities on the same topic differentiated for younger and older primary pupils. Clear guidelines are provided for discussion and activities which could take place in Circle Time. At the end of each section there is a story for children to consider accompanied by developmental activities and activity sheets, as well as a page of reflections related to the global challenges we all face. This exciting resource will act as a starting point for stimulating teachers and encouraging children to widen their learning. Teachers will be able to use these activities to set further challenges, to help explore current situations and to help with understanding present concerns. Margaret Collins is a former headteacher of infant and first schools. She is now Senior Visiting Fellow in the School of Education at the University of Southampton. She researches children's perceptions of health education topics, writes teaching materials for children, books and articles on PSHE.

' The book shows you how to confidently intergrate music into circle time and will be a useful addition to many teachers' resources'-Early Years Update '[A]n excellent resource for all teachers looking to introduce music to children aged from four to seven-years-old... The instructions are clear and precise, making it easy to use... an invaluable resource for all busy practitioners' - Early Years Educator 'The book is packed with ideas and the simple format makes it easy to use. Many of the suggestions can be used straight from the book or easily adapted to fit the interests of your own class... The book shows you how to confidently integrate music into circle time and will be a useful addition to many teachers' resources' - Early Years Update In the same popular and accessible style as Margaret Collins' established and successful Circle Time series, this book provides user-friendly classroom activities to engage young children. It uses Circle Time techniques to help children use and learn about: o rhythm, jingles, raps and chants o songs o instruments o ring games o music, art and story projects. The enjoyable activities can also enhance learning of other aspects of the curriculum. There is evidence that children who are familiar with a wide ranging repertoire of rhymes and songs learn to read earlier. Using this book all teachers will be able to use music in their Circle Time sessions in a confident and creative manner. Margaret Collins is a former headteacher of infant and first schools. She is now Senior Visiting Fellow in the School of Education at the University of Southampton. She researches children's perceptions of health education topics, writes teaching materials for children, books and articles on PSHE.

Schools are now asked to complete self-evaluation forms and update these annually. They not only require specific information about the views of learners, but also want to know how this information is gathered. Children's Voices provides a simple structure for gathering and assessing the views of pupils and parents/carers. This book will help to meet the school's needs in this evaluation and, in particular, to complete the SEFs which take into account the views of everyone connected with the schools including those of children. It is not only the collection of data and views that are important. When people are listened to they feel empowered with an improved view of their own self-worth. They, adults and children, feel that they belong to the community, have something to offer and are worthy of taking on some responsibility for the part they play in that community. As well as using data from the various sections in this book to complete the SEFs listening to what the children are telling us will improve our teaching or techniques to meet their needs. Listening to children's voices is only the first step. It is the action we take about what they say that is important. Who is Children's Voices for? Children's Voices is designed as a programme for teachers in mainstream schools. It will also be useful for teachers of children with special needs and classroom assistants working with individual children or very small groups. It is also suitable for use in special schools and with students in training establishments.