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Autophagy principally serves an adaptive function to protect
organisms against diverse human pathologies, including cancer and
neurodegeneration. Recent developments using in vitro, ex vivo and
in vivo models show the involvement of the autophagy pathway in
immunity and inflammation. Moreover, direct interactions between
autophagy proteins and immune signalling molecules have also been
demonstrated. Defects in autophagy - similar to cancer,
neurodegenerative diseases and aging - through autophagy gene
mutation and/or microbial antagonism, may underlie the pathogenesis
of many infectious diseases and inflammatory syndromes. In spite of
the increasing awareness of the importance of autophagy in these
pathophysiological conditions, this process remains underestimated
and is often overlooked. As a consequence, its role in the
initiation, stability, maintenance, and progression of these
diseases are still poorly understood. This book reviews the recent
advances regarding the functions of the autophagy pathway and
autophagy proteins in immunity and inflammation, focusing on their
role in self-nonself distinction, their implications in innate and
adaptive immune responses and their dysregulation in the pathology
of certain inflammatory and autoimmune diseases.
Autophagy principally serves an adaptive function to protect
organisms against diverse human pathologies, including cancer and
neurodegeneration. Recent developments using in vitro, ex vivo and
in vivo models show the involvement of the autophagy pathway in
immunity and inflammation. Moreover, direct interactions between
autophagy proteins and immune signalling molecules have also been
demonstrated. Defects in autophagy - similar to cancer,
neurodegenerative diseases and aging - through autophagy gene
mutation and/or microbial antagonism, may underlie the pathogenesis
of many infectious diseases and inflammatory syndromes. In spite of
the increasing awareness of the importance of autophagy in these
pathophysiological conditions, this process remains underestimated
and is often overlooked. As a consequence, its role in the
initiation, stability, maintenance, and progression of these
diseases are still poorly understood. This book reviews the recent
advances regarding the functions of the autophagy pathway and
autophagy proteins in immunity and inflammation, focusing on their
role in self-nonself distinction, their implications in innate and
adaptive immune responses and their dysregulation in the pathology
of certain inflammatory and autoimmune diseases.
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