Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA). This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results.

London, 1938. With a world war on the horizon, a shocking crime begins to unfold - and one reporter knows too much to be allowed to survive. An absorbing and gripping mystery from the critically acclaimed author of SNOW HILL. November, 1938. Europe is teetering on the edge of war...Anti-Semitism is on the rise in Britain, and a serial killer is at work in London. Johnny Steadman, investigative journalist, is called to the scene of a gruesome murder - a man has been tied to his bed, mutilated and left to bleed to death. This is the second time the killer has struck, and it won't be the last. Together with DC Matt Turner, Johnny tries desperately to find a link between the victims. When the next Mayor of London is subjected to a vicious Anti-Semitic attack, Johnny begins to wonder if the two cases are connected. Against a backdrop of escalating violence in Nazi Germany, he uncovers a shocking conspiracy that could bring the United Kingdom to its knees. But will Johnny live to tell the tale?

This book constitutes the refereed proceedings of the 13th International Conference on String Processing and Information Retrieval, SPIRE 2006. The 26 revised full papers and 5 revised short papers presented together with 2 invited talks were carefully reviewed and selected. The papers are organized in topical sections on Web clustering and text categorisation, strings, user behaviour, Web search algorithms, compression, correction, information retrieval applications, bio-informatics, and Web search engines.

During recent years, huge efforts have been made to establish digital libraries, in a variety of media, offered from a variety of sources, and intended for a variety of professional and private user communities. As digital data collections proliferate, problems of resource selection and data fusion become major issues. Traditional search engines, even the best ones, are unable to provide access to the hidden web of information that is only available via digital library search interfaces.

Originating from the SIGIR 2003 Workshop on Distributed Information Retrieval, held in Toronto, Canada in August 2003, this book presents extended and revised workshop papers as well as several invited papers on the topic to round off coverage of the core issues. The papers are devoted to recent research on the design and implementation of methods and tools for resource discovery, resource description, resource selection, data fusion, and user interaction.

This book constitutes the refereed proceedings of the 5th International Conference of the CLEF Initiative, CLEF 2014, held in Sheffield, UK, in September 2014. The 11 full papers and 5 short papers presented were carefully reviewed and selected from 30 submissions. They cover a broad range of issues in the fields of multilingual and multimodal information access evaluation, also included are a set of labs and workshops designed to test different aspects of mono and cross-language information retrieval systems

Don't Look Now, released in 1973, confirmed director Nicolas Roeg as one of the
most stylish and innovative British directors of the postwar period. Adapted
from a short story by Daphne du Maurier, it is both a complex study of how
people come to terms with grief and a chilling tale of murder set among the
canals and churches of Venice. Featuring telling performances by Julie Christie
and Donald Sutherland as the couple whose daughter has tragically died,
Don't Look Now depicts the way in which the macabre and the everyday are
intertwined.

In his lucid, subtle account, Mark Sanderson describes the collaboration
between director and actors that sustained the film's emotional richness.
He returns to du Maurier's original text and to the traditions of Gothic writing
that underpin Don't Look Now's combination of horror, melodrama and black
comedy. Sanderson examines the film's intricate visual style, uncovering the
way in which particular motifs are used to amplify its depiction of two terrible
deaths. He finds compensation for the film's grimly fatalistic view of life in its
celebration of sexual relationships and the power of recollection. The book
includes an exclusive and in-depth interview with Roeg as well as rare and
unpublished comments from Christie.

In his foreword to this special edition, published to celebrate the 20th
anniversary of the BFI Film Classics series, Jason Wood places Don't Look Now
in the context of Roeg's film-making careeer, and draws upon Roeg's revealing
insights into the film's production.