The healthcare system is experiencing unprecedented challenges and opportunities that will revolutionize the sector. The rising demand for health services and the resources restrictions have put increased pressure on healthcare organizations to improve cost-efficiency and service offerings. The pandemic has further exacerbated the main pressure points of the healthcare sector. Currently, the shift towards patient centricity is gaining momentum, therefore there is a need to rethink how health systems can embrace this concept, in particular with digitization, service innovation and value co-creation. Focusing on digital healthcare, this book proposes a theoretical framework, along with managerial implications, on moving towards a patient-centric model. It explores the role of digitization and innovation in solving existing challenges in the sector, and includes the concept of 'One Digital Health', which refers to global health and transformation and recognizes the importance of the connection between humans, animals, nature and the interrelation of different health systems. With clear implications to Sustainable Development Goal 3: 'Ensure healthy lives and promote wellbeing for all at all ages,' the authors argue that innovative transformation in the sector can support the Agenda 2030.