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A synthesis and collation of the recent material regarding the role
of the neutrophil in basic pathological processes is presented in
this volume. The mechanisms of chemotaxis, secretion, phagocytosis,
intracellular killing, oxygen radical production and arachidonate
production are comprehensively reviewed. Stimulus response coupling
in the neutrophil, with chapters on intracellular Ca2+, C-Kinase,
phospholipid metabolism, microfilaments and membrane
electrophysiology are extensively discussed. Each chapter provides
a critical review by experts with over 1,000 cited references.
Invaluable to graduate students and medical and scientific
researchers, this book provides a unique, up-to-date account of
cellular biochemistry and physiology of the neutrophil.
Phagocytosis is the engulfment of particulate matter by cells. It
is a fundamental (and probably "primitive") cell biological process
which is important in single celled organisms such as amoeba;
multicellular animals including coelenterates; and in higher
animals. In humans and other mammals, specialised immune cells
(phagocytes) utilise phagocytosis in their crucial role of
engulfing and destroying infecting microbes. Yet, surprisingly, the
biophysics and biochemistry underlying the process has only become
clear recently with the advent of genetic manipulation and advances
in single cell imaging. In this volume, the aim is to bring
together recent fundamental advances that give a clear picture of
the underlying mechanism involved in phagocytosis. Not only is this
an important topic in its own right, but a full understanding of
the process will have a potential impact on human medicine, since
as antibiotics become less effective in fight infection,
researchers are looking at alternative approaches, including
enhancing the "natural" immunity brought about by immune
phagocytes. The aim is to provide a comprehensive volume on the
topic, with separate chapters on identified recent advances, each
written by the major contributors in each area. In addition, the
volume will attempt to give a wider overview than is often the case
in single author reviews, with an emphasis here on the cell
biological understanding of phagocytosis using biophysical
approaches alongside the biochemical and imaging approaches.
Phagocytosis is the engulfment of particulate matter by cells. It
is a fundamental (and probably "primitive") cell biological process
which is important in single celled organisms such as amoeba;
multicellular animals including coelenterates; and in higher
animals. In humans and other mammals, specialised immune cells
(phagocytes) utilise phagocytosis in their crucial role of
engulfing and destroying infecting microbes. Yet, surprisingly, the
biophysics and biochemistry underlying the process has only become
clear recently with the advent of genetic manipulation and advances
in single cell imaging. In this volume, the aim is to bring
together recent fundamental advances that give a clear picture of
the underlying mechanism involved in phagocytosis. Not only is this
an important topic in its own right, but a full understanding of
the process will have a potential impact on human medicine, since
as antibiotics become less effective in fight infection,
researchers are looking at alternative approaches, including
enhancing the "natural" immunity brought about by immune
phagocytes. The aim is to provide a comprehensive volume on the
topic, with separate chapters on identified recent advances, each
written by the major contributors in each area. In addition, the
volume will attempt to give a wider overview than is often the case
in single author reviews, with an emphasis here on the cell
biological understanding of phagocytosis using biophysical
approaches alongside the biochemical and imaging approaches.
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