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Modulation of Oxidative Stress: Biochemical, Physiological and
Pharmacological Aspects explores the field using an
interdisciplinary approach, including chemical, biological,
physiological, pharmaceutical, pharmacological and physicochemical
perspectives. The book is comprised of three main parts, with the
first discussing the biochemical aspects of oxidative stress
modulation. Other sections cover physiological and
pathophysiological aspects on relevant conditions, including aging,
neurological diseases, cerebral cavernous malformation, maternal
and early-life malnutrition, Alzheimer’s disease, liver
transplant, and cancer. Final content is dedicated to
pharmacological aspects and includes chapters on phytotherapy and
flavonoids. This book is a strong reference for pharma researchers
in academia and industry considering leveraging modulation of
oxidative stress as a strategy for the development of new drugs.
Biochemists and Nutritionists may also benefit of the foundational
understanding of cellular redox processes laid out.
This second edition provides new and updated chapters detailing all
major elements of the ECB system. Chapters guide readers through
identification of drug targets, electrophysiology, computational
chemistry, and machine learning. Written in the successful Methods
in Molecular Biology series format, chapters include introductions
to their respective topics, lists of the necessary materials and
reagents, step-by-step, readily reproducible protocols, and notes
on troubleshooting and avoiding known pitfalls. Comprehensive and
cutting-edge, Endocannabinoid Signaling: Methods and Protocols,
Second Edition is a valuable resource for all researchers
interested in learning more about this important and developing
field.
Legalization of cannabis extracts around the world has led to a
resurgence of interest into research surrounding endocannabinoids
(eCBs) and the endocannabinoid system. This system is formed of a
complex array of receptors, metabolic enzymes and transporters that
finely tune the manifold biological activities of eCBs and there is
an urgent need for the development of selective drugs to dissect
the contribution of eCBs to the aetiology of various diseases. New
Tools to Interrogate Endocannabinoid Signalling comprehensively
covers the innovative research into both natural and synthetic
compounds that affect this pathway and taking a target-based
approach, assesses their potential for therapeutic use. With
contributions from global leaders in the field, this timely volume
will be a valuable resource to pharmaceutical researchers and
medicinal chemists working in natural products and endocannabinoid
drug discovery in academia and industry.
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