Recent advances in the understanding of the major events that shape the immune recog nition system have been remarkable. The analysis of immunoglobulin (Ig) gene organization and Ig repertoire diversification in lower vertebrates has provided new insight into this process in mammals. Similarly, the understanding of the early development of lymphocytes and of the acquisition of immunological tolerance has been aided by elegant studies in quail/chicken chimeras, using the power of the distinctive markers of the constitutive cells of these birds. Great strides have been made in understanding the role played by major histocompatibility complex (MHC) molecules in antigen presentation and in repertoire selec tion within the thymus. The use of transgenic mice expressing specific T-cell receptor (TCR) genes has elucidated the process of both positive and negative selection. In parallel, there has been considerable progress in our understanding of tolerance, based in part on the use of markers for the V fJ genes of T-cell receptors and in part on the analysis of the behavior of long term T-cell lines. This has led to the realization that both clonal deletion and clonal anergy may play critical roles in the maintenance of unresponsiveness to self antigen. Molecular analysis of the requirements for expression of membrane immunoglobulin molecules has revealed the existence of a complex that appears to be of critical importance in mediating signalling through Ig receptors. In addition, major insights have been obtained into the regulation of expression of genes of immunologic interest.

The articles in this volume cover recent work in the area of flow control from the point of view of both engineers and mathematicians. These writings are especially timely, as they coincide with the emergence of the role of mathematics and systematic engineering analysis in flow control and optimization. Recently this role has significantly expanded to the point where now sophisticated mathematical and computational tools are being increasingly applied to the control and optimization of fluid flows. These articles document some important work that has gone on to influence the practical, everyday design of flows; moreover, they represent the state of the art in the formulation, analysis, and computation of flow control problems. This volume will be of interest to both applied mathematicians and to engineers.

In recent years, major developments have been made in understanding various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. A role and mechanism of DNA repair proteins in somatic hypermutation has been elucidated. Genetic mutation studies have been instrumental in providing insight into some of the mechanisms involved in targeting CSR to various switch DNA regions located upstream of C region genes, especially a role of AID motifs, transcription, and R-loops. Recent studies support a dominant role of receptor editing in central B cell tolerance and signaling pathways that regulate receptor editing in self-reactive and non-self-reactive immature B cells. These were some of the topics of discussion at the 11th International Conference on B cell Biology. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.

Since their emergence, finite element methods have taken a place as one of the most versatile and powerful methodologies for the approximate numerical solution of Partial Differential Equations. These methods are used in incompressible fluid flow, heat, transfer, and other problems. This book provides researchers and practitioners with a concise guide to the theory and practice of least-square finite element methods, their strengths and weaknesses, established successes, and open problems.

In recent years, major developments have increased understanding of various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.

Rapid developments continue to take place in the research of viruses, the causative agents of infectious diseases in humans, animals, plants, invertebrates, protozoa, fungi, and bacteria. A still growing number of more than 30,000 viruses, virus strains, and subtypes are being tracked in various specialty laboratories and culture collections. In this situation of expansion and specialization, the International Committee on Taxonomy of Viruses was founded to establish, refine and maintain a universal virus taxonomy system giving information to virologists about the characteristics of the different groups of viruses. The Committee s Sixth Report includes one order, 71 families, 11 subfamilies, and 175 genera and more than 4,000 member viruses. On 600 printed pages large amounts of molecular biologic data, illustrated by micrographs and virion diagrams, gene maps and tables give a comprehensive overview and prove helpful in teaching, in diagnostics, in scholarly research, and in the practical areas of medicine, veterinary medicine, plant pathology, insect pest management, and biotechnology. ..". est une reference indispensable pour les chercheurs, les enseignants, les medecins ou les veterinaires mais aussi pour les etudiants et d une maniere generale pour toutes les personnes interessees par la virologie . Revue de Medecine Veterinaire ..". an excellent, well presented and informative volume. The report should be an essential reference volume for any department or organization involved in the study of viruses . Quarterly"

Pigs are among the most peculiar animals domesticated in the Ancient Near East. Their story, from domestication to taboo, has fascinated historians, archaeologists, and religious studies scholars for decades. Rejecting simple explanations, this book adopts an evolutionary approach that relies on zooarchaeology and texts to unravel the cultural significance of swine in the Near East from the Paleolithic to the present day. Five major themes are covered: The domestication of the pig from wild boars in the Neolithic period, the unique roles that pigs developed in agricultural economies before and after the development of complex societies, the raising of swine in cities, the shifting ritual roles of pigs, and the formation and development of the pork taboo in Judaism and, later, Islam. The origins and significance of this taboo have inspired much debate. Evolution of a Taboo contends that the well-known taboo described in Leviticus evolved over time, beginning with conflicts between Israelites and Philistines in the early part of the Iron Age, and later was mobilized by Judah's priestly elite in the writing of the Biblical texts. Centuries later, the pig taboo became a point of contention in the ethno-political struggles between Jewish and Greco-Roman cultures in the Levant; later still, between Jews, Christians, and Muslims. Through these conflicts, the pig taboo grew in power. As this rich account illustrates, it came to define the relations between pigs and people in the Near East and beyond, up to the present day.

Since their emergence, finite element methods have taken a place as one of the most versatile and powerful methodologies for the approximate numerical solution of Partial Differential Equations. These methods are used in incompressible fluid flow, heat, transfer, and other problems. This book provides researchers and practitioners with a concise guide to the theory and practice of least-square finite element methods, their strengths and weaknesses, established successes, and open problems.