Scientists are deciphering the biology of the tumor cell at a level of detail that would have been hard to imagine just a decade or so ago. The development of high-throughput DNA sequencing and genomics technologies have allowed an understanding of the development, growth, survival, and spread of cancer cells in the body. From this information, we now have a basic blueprint or roadmap of how a single damaged cell can develop into a pre-malignant lesion, a primary tumor, and finally, a lethal tumor that may spread throughout the body and resist both medical therapy and host immune responses. In this book, we provide an overview of our current understanding of this cancer blueprint, which has been aided both by the study of familial cancer syndromes, in vitro studies of cancer cells, and animal models. Three classes of genes have emerged from these studies: tumor suppressor genes needed for normal growth control and DNA repair; oncogenes that regulate cell growth and survival, and epigenetic modifiers, enzymes that regulate the modification of DNA and the proteins that form chromatin. Each of these three classes of genes is mutated or altered at least once in virtually all malignant cancer cells. Current technologies permit the DNA sequencing of cancer exomes (coding gene sequencing), whole genomes, transcriptome (all expressed genes), and DNA methylation profiling. These studies show that all tumors have unique constellations of mutated, rearranged, amplified, and deleted genes. Single-cell sequencing further shows that there is extensive variation in individual cells in the tumor; that cancers evolve, and have many of the properties of a multi-cellular entity. Lastly, cancer cells, through mutations in epigenetic modifiers, can reprogram the genome and unlock entire developmental and gene expression pathways to adapt and survive in changing conditions. This reprogramming allows the tumor to elude the host body's defenses, radiotherapy, chemotherapy, and targeted therapy that we use in cancer treatment. Understanding this cancer blueprint paves the way for the development of future therapies to treat and eliminate cancer.

Growing out of recent pedagogical developments in creative writing studies and perceived barriers to teaching the subject in secondary education schools, this book creates conversations between secondary and post-secondary teachers aimed at introducing and improving creative writing instruction in teaching curricula for young people. Challenging assumptions and lore regarding the teaching of creative writing, this book examines new and engaging techniques for infusing creative writing into all types of language arts instruction, offering inclusive and pedagogically sound alternatives that consider the needs of a diverse range of students. With careful attention given to creative writing within current standards-based educational systems, Imaginative Teaching through Creative Writing confronts and offers solutions to the perceived difficulty of teaching the subject in such environments. Divided into two sections, section one sees post-secondary instructors address pedagogical techniques and concerns such as workshop, revision, and assessment before section two explores hands-on activities and practical approaches to instruction. Focusing on an invaluable and underrepresented area of creative writing studies, this book begins a much-needed conversation about the future of creative writing instruction at all levels and the benefits of collaboration across the secondary/post-secondary divide.

Lecture provides an overview of the progress made in molecular medicine applying genetics and genomics to the understanding, diagnosis, and treatment of human diseases. Specifically, the methods for identifying genes involved in human diseases are described. Examples from 10 genes and diseases will be provided, drawing on the author's research. Topics include examples from simple Mendelian diseases, such as cystic fibrosis, inherited cancers, oncogenes activated by chromosomal translocations, host genes involved in infectious disease, genes identified via genomewide association studies, pathogens causing cancer, and gene families contributing to multiple diseases. For each example, historical details will be provided as background for readers to understand the context and process of the discoveries, technologies explained, and current understanding and treatment implications detailed.

"Creative Writing in the Digital Age" explores the vast array of opportunities that technology provides the Creative Writing teacher, ranging from effective online workshop models to advances that blur the boundaries of genre. From social media tools such as Twitter and Facebook to more advanced software like Inform 7, the book investigates the benefits and potential troubles these technologies afford instructors in the classroom.Each chapter addresses relevant, contemporary theories of creative writing and digital pedagogy through specific classroom practices and draws on direct classroom experience. Written with the everyday instructor in mind, the book includes practical classroom lessons that can be easily adapted to creative writing courses regardless of the instructor's technical expertise. From the absolute beginner to the computer savvy, "Creative Writing in the Digital Age" will challenge and expand readers' notions about the possibilities of creative writing instruction.

The essence of, Blissful Lantern, offers you a pure light of bliss, to guide you on the path of awakening and enlightenment, through, Silent Awareness Meditation. The essence of this, allows you to generate a pure intention, freeing you and all others of suffering. Through pure awareness of the way all things truly exist, you may begin a blissful spiritual life, free of tension, anxiety, confusion and suffering. This leads to both inner and outer peace...

When teachers experiment, students benefit. When students gain confidence to pursue their own literary experiments, creative writing can become a life-changing experience. With chapters written by experienced teachers and classroom innovators, Creative Writing Innovations builds on these principles to uncover the true potential of the creative writing classroom. Rooted in classroom experience, this book takes teaching beyond the traditional workshop model to explore topics such as multi-media genres, collaborative writing and field-based work, as well as issues of identity. Taken together, this is an essential guide for teachers of creative writing at all levels from the authors and editors of Creative Writing in the Digital Age.

The definitive Comics Journal interviews with the cartoonists behind Zap Comix, featuring: Supreme 1960s counterculture/underground artist Robert Crumb on how acid unleashed a flood of Zap characters from his unconscious; Marxist brawler Spain Rodriguez on how he made the transition from the Road Vultures biker gang to the exclusive Zap cartoonists club; Yale alumnus Victor Moscoso and Christian surfer Rick Griffin on how their poster-art psychedelia formed the backdrop of the 1960s San Francisco music scene; Savage Id-choreographer S. Clay Wilson on how his dreams insist on being drawn; Painter and Juxtapoz-founder Robert Williams on how Zap #4 led to 150 news-dealer arrests; Fabulous, Furry, Freaky Gilbert Shelton on the importance of research; Church of the Subgenius founder Paul Mavrides on getting a contact high during the notorious Zap jam sessions; and much more. In these career-spanning interviews, the Zap contributors open up about how they came to create a seminal, living work of art."

A Diamond in the Dust is a fictionalised account of the life of Charles I from his birth to the age of twenty-eight. It shows England's most maligned monarch, Charles I, as he really was. Dominated by his debauched father, James I, he grew up a diffident, stuttering, dreamy figure, wracked by a crippling disease - rickets. But he was lifted and defined by his passion for all the arts, especially theatre and painting. Brutal real-life caught up with him, however, spinning him at the centre of a whirlwind of love, art, war and even murder, as he struggled unsuccessfully to keep control of his life and his kingdom. This first novel in the trilogy The Stuarts: Love, Art, War, shows Charles I growing up and finding love. It puts the vilified king in a different light. Under the wing of his precocious sister Elizabeth he blossoms and his interest in culture and the arts grows into a passion or some would say an obsession.

Hogarth's epoch-defining paintings and engravings, such as Gin Lane and The Rake's Progress, are renowned. He was London's painter par excellence, and supplies the most enduring vision of the eighteenth century's ebullience, enjoyments and social iniquities. From his lifelong marriage to Jane Thornhill, his inability to have children, his time as one of England's best portrait painters, his old age and unfortunate dip into politics, and ultimately his death, I, Hogarth is the artist's life through his very own eyes. Recommended for readers of Peter Ackroyd and Hilary Mantel, this novel charts Hogarth's personal story in four parts carefully blending the facts of his life with fiction, beginning with a childhood spent in a debtor's prison and ending with his death in the arms of his wife.

The White Crucifixion starts with Chagall's difficult birth in Vitebsk 1887, in the present-day Belarus, and tells the unlikely story of how the eldest son of a herring schlepper became enrolled in art school where he quickly gained a reputation as `Moyshe, the painting wonder'. The novel paints an authentic picture of a Russian town divided by belief and wealth, rumours of pogroms never far away, yet bustling with talented young artists. In 1913 Chagall relished the opportunity to move to Paris to take up residence in the artist colony The Hive (La Ruche). The Yiddish-speaking artists (Ecole Juive) living there were all poor. The Hive had no electric light, or running water and yet many of its artists were to become famous, among them Amedeo Modigliani and Osip Zadkine. The novel vividly portrays the dynamics of an artist colony, its pettiness, friendships and the constant battle to find the peace and quiet to work. In 1914 Chagall and Bella make what's supposed to be a fleeting visit to his beloved Vitebsk, only to get trapped there by the outbreak of the first world war, the subsequent Russian revolution, and the establishment of the communist regime which is increasingly hostile towards artists like Chagall. Yet, Chagall keeps on painting, and the novel provides a fascinating account of what inspired some of his greatest painting. He manages to return to France and is reunited with his paintings only to be thwarted by yet another world war which proves disastrous for the people he knew in Vitebsk which include his uncle Neuch, the original `fiddler on the roof'. The White Crucifixion is a fictionalised account of the rollercoaster life of one of the most enigmatic artists of the twentieth century.

An outspoken opponent of pro-Russian, authoritarian, and far-right streams in contemporary Czech society, Martin C. Putna received a great deal of media attention when he ironically dedicated the Czech edition of Russ-Ukraine-Russia to Milos Zeman--the pro-Russian president of the Czech Republic. This sense of irony, combined with an extraordinary breadth of scholarly knowledge, infuses Putna's book. Examining key points in Russian cultural and spiritual history, Russ-Ukraine-Russia is essential reading for those wishing to understand the current state of Russia and Ukraine--the so-called heir to an "alternative Russia." Putna uses literary and artistic works to offer a rich analysis of Russia as a cultural and religious phenomenon: tracing its development from the arrival of the Greeks in prehistoric Crimea to its invasion by "little green men" in 2014; explaining the cultural importance in Russ of the Vikings as well as Pussy Riot; exploring central Russian figures from St. Vladimir the Great to Vladimir Putin. Unique in its postcolonial perspective, this is not merely a history of Russia or of Russian religion. This book presents Russia as a complex mesh of national, religious, and cultural (especially countercultural) traditions--with strong German, Mongol, Jewish, Catholic, Polish, and Lithuanian influences--a force responsible for creating what we identify as Eastern Europe.

"The most consistent of all series in terms of language control, length, and quality of story." David R. Hill, Director of the Edinburgh Project on Extensive Reading.

"The most consistent of all series in terms of language control, length, and quality of story." David R. Hill, Director of the Edinburgh Project on Extensive Reading.

From journalist Michelle Dean, winner of the National Book Critics Circle's 2016 Nona Balakian Citation for Excellence in Reviewing, Sharp combines biography, original research, and critical reading into a powerful portrait of ten writers who managed to make their voices heard amidst a climate of sexism and nepotism, from the 1920s to the 1990s. Dorothy Parker, Rebecca West, Mary McCarthy, Hannah Arendt, Susan Sontag, Joan Didion, Janet Malcolm, Renata Adler, Pauline Kael, and Nora Ephron-these are the main characters of Sharp. Their lives intertwine. They enable each other and feud, manufacture unique spaces and voices, and haunt each other. They form a group united in many ways, but especially by what Dean terms as 'sharpness', the ability to cut to the quick with precision of thought and wit, a claiming of power through writing rather than position. Sharp is a vibrant and rich depiction of the intellectual beau monde of New York, where gossip-filled parties at night gave out to literary slanging-matches in the pages of publications like the Partisan Review or the New York Review of Books, as well as a carefully considered portrayal of the rise of feminism and its interaction with the critical establishment. Sharp is for book lovers who want to read about their favorite writers, lovers of New Yorker lore, aspiring writers in New York, those interested in the history of ideas, and of the fray of 20th century debate-and it will satisfy them all.

A BBC Radio 4 Book of the Week 'This is such a great idea for a book, and Michelle Dean carries it off, showing us the complexities of her fascinating, extraordinary subjects, in print and out in the world. Dean writes with vigor, depth, knowledge and absorption, and as a result Sharp is a real achievement' Meg Wolitzer, New York Times Dorothy Parker, Hannah Arendt, Mary McCarthy, Susan Sontag, Joan Didion, Nora Ephron and Janet Malcolm are just some of the women whose lives intertwined as they cut through twentieth-century cultural and intellectual life in the United States, arguing as fervently with each other as they did with the men who so often belittled their work as journalists, novelists, critics and poets. These women are united by their 'sharpness': an accuracy and precision of thought and wit, a claiming of power through their writing. Sharp is a rich and lively portrait of these women and their world, where Manhattan cocktail parties, fuelled by lethal quantities of both alcohol and gossip, could lead to high-stakes slanging matches in the Partisan Review or the New York Review of Books. It is fascinating and revealing on how these women came to be so influential in a climate in which they were routinely met with condescension and derision by their male counterparts. Michelle Dean mixes biography, criticism and cultural and social history to create an enthralling exploration of how a group of brilliant women became central figures in the world of letters, staked out territory for themselves and began to change the world.

Set during World War I on an isolated country estate just outside London, Rebecca West's haunting novel The Return of the Soldier follows Chris Baldry, a shell-shocked captain suffering from amnesia, as he makes a bittersweet homecoming to the three women who have helped shape his life. Will the devoted wife he can no longer recollect, the favorite cousin he remembers only as a childhood friend, and the poor innkeeper's daughter he once courted leave Chris to languish in a safe, dreamy past--or will they help him recover his memory so that he can return to the front? The answer is revealed through a heartwrenching, unexpected sacrifice.
The text of this Modern Library Paperback Classic was set from the first American edition, published in 1918, and features original illustrations by Norman Price.

A BBC Radio 4 Book of the Week 'This is such a great idea for a book, and Michelle Dean carries it off, showing us the complexities of her fascinating, extraordinary subjects, in print and out in the world. Dean writes with vigor, depth, knowledge and absorption, and as a result Sharp is a real achievement' Meg Wolitzer, New York Times Dorothy Parker, Hannah Arendt, Mary McCarthy, Susan Sontag, Joan Didion, Nora Ephron and Janet Malcolm are just some of the women whose lives intertwined as they cut through twentieth-century cultural and intellectual life in the United States, arguing as fervently with each other as they did with the men who so often belittled their work as journalists, novelists, critics and poets. These women are united by their 'sharpness': an accuracy and precision of thought and wit, a claiming of power through their writing. Sharp is a rich and lively portrait of these women and their world, where Manhattan cocktail parties, fuelled by lethal quantities of both alcohol and gossip, could lead to high-stakes slanging matches in the Partisan Review or the New York Review of Books. It is fascinating and revealing on how these women came to be so influential in a climate in which they were routinely met with condescension and derision by their male counterparts. Michelle Dean mixes biography, criticism and cultural and social history to create an enthralling exploration of how a group of brilliant women became central figures in the world of letters, staked out territory for themselves and began to change the world.